Effects of ultrasound-assisted compaction on Ketoprofen/Eudragit® S100 Mixtures
Ketoprofen alone and in binary mixtures with Eudragit® S100 was compacted by an ultrasound-assisted (US) tableting machine at an energy ranging from 50 to 400 J. The final material was analysed by TLC and HPLC: no decomposition product of the active agent was found. IR spectra and HSM revealed the a...
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| Veröffentlicht in: | European journal of pharmaceutical sciences 1999-02, Vol.7 (3), p.207-213 |
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| container_title | European journal of pharmaceutical sciences |
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| creator | Sancin, Pietro Caputo, Otto Cavallari, Cristina Passerini, Nadia Rodriguez, Lorenzo Cini, Maurizio Fini, Adamo |
| description | Ketoprofen alone and in binary mixtures with Eudragit® S100 was compacted by an ultrasound-assisted (US) tableting machine at an energy ranging from 50 to 400 J. The final material was analysed by TLC and HPLC: no decomposition product of the active agent was found. IR spectra and HSM revealed the absence of any interaction between the two components. Thermal analysis (DSC) evidenced that ketoprofen inside the mixtures was transformed into an amorphous state, documented by the decreasing of the
ΔH
fus as the Eudragit®/ketoprofen ratio increases and as US energy increases. While pure ketoprofen recovers its crystalline state quickly after the US treatment, the presence of Eudragit® was found to slow down or possibly to prevent the regeneration of the crystallinity. |
| doi_str_mv | 10.1016/S0928-0987(98)00022-0 |
| format | Article |
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ΔH
fus as the Eudragit®/ketoprofen ratio increases and as US energy increases. While pure ketoprofen recovers its crystalline state quickly after the US treatment, the presence of Eudragit® was found to slow down or possibly to prevent the regeneration of the crystallinity.</description><identifier>ISSN: 0928-0987</identifier><identifier>EISSN: 1879-0720</identifier><identifier>DOI: 10.1016/S0928-0987(98)00022-0</identifier><identifier>PMID: 9845807</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Acrylic Resins - chemistry ; Amorphous state ; Anti-Inflammatory Agents, Non-Steroidal - chemistry ; Biological and medical sciences ; Differential thermal analysis ; Drug Compounding ; Eudragit® S100 ; Excipients - chemistry ; General pharmacology ; Ketoprofen ; Ketoprofen - chemistry ; Medical sciences ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Polymethacrylic Acids ; Tablets ; Ultrasonics ; Ultrasound compaction</subject><ispartof>European journal of pharmaceutical sciences, 1999-02, Vol.7 (3), p.207-213</ispartof><rights>1999 Elsevier Science B.V.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-3abcd79320d14908591a2f223379c578ac5fce3d3cb434ccc81693ee68ad5aed3</citedby><cites>FETCH-LOGICAL-c480t-3abcd79320d14908591a2f223379c578ac5fce3d3cb434ccc81693ee68ad5aed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0928098798000220$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1651179$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9845807$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sancin, Pietro</creatorcontrib><creatorcontrib>Caputo, Otto</creatorcontrib><creatorcontrib>Cavallari, Cristina</creatorcontrib><creatorcontrib>Passerini, Nadia</creatorcontrib><creatorcontrib>Rodriguez, Lorenzo</creatorcontrib><creatorcontrib>Cini, Maurizio</creatorcontrib><creatorcontrib>Fini, Adamo</creatorcontrib><title>Effects of ultrasound-assisted compaction on Ketoprofen/Eudragit® S100 Mixtures</title><title>European journal of pharmaceutical sciences</title><addtitle>Eur J Pharm Sci</addtitle><description>Ketoprofen alone and in binary mixtures with Eudragit® S100 was compacted by an ultrasound-assisted (US) tableting machine at an energy ranging from 50 to 400 J. The final material was analysed by TLC and HPLC: no decomposition product of the active agent was found. IR spectra and HSM revealed the absence of any interaction between the two components. Thermal analysis (DSC) evidenced that ketoprofen inside the mixtures was transformed into an amorphous state, documented by the decreasing of the
ΔH
fus as the Eudragit®/ketoprofen ratio increases and as US energy increases. While pure ketoprofen recovers its crystalline state quickly after the US treatment, the presence of Eudragit® was found to slow down or possibly to prevent the regeneration of the crystallinity.</description><subject>Acrylic Resins - chemistry</subject><subject>Amorphous state</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - chemistry</subject><subject>Biological and medical sciences</subject><subject>Differential thermal analysis</subject><subject>Drug Compounding</subject><subject>Eudragit® S100</subject><subject>Excipients - chemistry</subject><subject>General pharmacology</subject><subject>Ketoprofen</subject><subject>Ketoprofen - chemistry</subject><subject>Medical sciences</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. 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ΔH
fus as the Eudragit®/ketoprofen ratio increases and as US energy increases. While pure ketoprofen recovers its crystalline state quickly after the US treatment, the presence of Eudragit® was found to slow down or possibly to prevent the regeneration of the crystallinity.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>9845807</pmid><doi>10.1016/S0928-0987(98)00022-0</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0928-0987 |
| ispartof | European journal of pharmaceutical sciences, 1999-02, Vol.7 (3), p.207-213 |
| issn | 0928-0987 1879-0720 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acrylic Resins - chemistry Amorphous state Anti-Inflammatory Agents, Non-Steroidal - chemistry Biological and medical sciences Differential thermal analysis Drug Compounding Eudragit® S100 Excipients - chemistry General pharmacology Ketoprofen Ketoprofen - chemistry Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polymethacrylic Acids Tablets Ultrasonics Ultrasound compaction |
| title | Effects of ultrasound-assisted compaction on Ketoprofen/Eudragit® S100 Mixtures |
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