Accurate pre-operative localization of pathological parathyroid glands using 11C-methionine PET/CT
Objective The pre‐operative technique most routinely used to localize pathological parathyroid glands (PPG), prior to minimal access surgery (MAS), relies on 99mTc‐sestamibi (MIBI) scintigraphy. Positron emission tomography (PET) using the radiolabelled amino acid 11C‐methionine as the tracer agent...
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| Veröffentlicht in: | Contrast media and molecular imaging 2008-07, Vol.3 (4), p.157-163 |
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| creator | Tang, Bich-Ngoc-Thanh Moreno-Reyes, Rodrigo Blocklet, Didier Corvilain, Bernard Cappello, Matteo Delpierre, Isabelle Devuyst, France Van Simaeys, Gaetan Goldman, Serge |
| description | Objective
The pre‐operative technique most routinely used to localize pathological parathyroid glands (PPG), prior to minimal access surgery (MAS), relies on 99mTc‐sestamibi (MIBI) scintigraphy. Positron emission tomography (PET) using the radiolabelled amino acid 11C‐methionine as the tracer agent offers a technological alternative to localize PPG. In this study we evaluated the sensitivity of 11C‐methionine PET/CT (MET‐PET/CT) for PPG detection and the extent to which MET‐PET/CT images may contribute to the planning of surgical procedures.
Design
Thirty patients were included, 22 with primary hyperparathyroidism and eight with secondary hyperparathyroidism. Patients suspected of suffering from parathyroid hyperplasia underwent a complete surgical exploration of the neck region. In those suspected of parathyroid adenoma, surgery was limited to the presumed localization described by MET‐PET/CT. To specifically address the additional benefit of the MET‐PET/CT in terms of surgical planning and procedure, the surgeon classified the patients into two categories depending on the type of benefit, or the reason for the absence of benefit, occurring in each case. We also compared the sensitivity of MET‐PET/CT and MIBI scintigraphy.
Results
The total number of lesions removed was 46 (24 adenomatous and 22 hyperplastic). Globally, MET‐PET/CT provided additional benefit to surgery in 15 out of 30 cases (50%). The sensitivity of 11C‐methionine PET/CT and MIBI scintigraphy was respectively 92% and 95% for adenoma, and 68% and 59% for hyperplasia, on the basis of available resected lesions.
Conclusion
MET‐PET/CT appears a reliable technique to guide MAS of parathyroid glands. Copyright © 2008 John Wiley & Sons, Ltd.
In this study of 30 patients, we demonstrate the additional benefits of the 11C‐methionine PET/CT (MET‐PET/CT) in the pre‐surgical planning for the resection of pathological parathyroid glands. We found that MET‐PET/CT benefits to 50% of the studied cases and is as sensitive as MIBI scintigraphy, for the detection of both adenoma (95% vs. 92%) hyperplasia (68% vs. 59%). Consequently, MET‐PET/CT could be considered as a reliable technique to guide minimal access surgery of parathyroid glands. |
| doi_str_mv | 10.1002/cmmi.243 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_69547124</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69547124</sourcerecordid><originalsourceid>FETCH-LOGICAL-i1963-d08b7bba346004a26d90185b04d7a70a2626b21f8bdf19d229748daad544a1553</originalsourceid><addsrcrecordid>eNpFkF1PwjAUhhujEUQTf4HZlXeDfm3dLnEBJAE1Zupl060Fqhud66bir7cEhKvz9Zw357wAXCPYRxDiQV6Wuo8pOQFdFASBTwlip4ccxh1wYe07hJSSmJyDDopYhIIId0E2zPO2Fo3yqlr5plIu11_KK0wuCv3rCrP2zMKrRLMyhVlq13aFo1ab2mjpLQuxltZrrV4vPYQSv1TNyi3ptfKeRukgSS_B2UIUVl3tYw-8jEdpcu_PHifTZDjzNYpD4ksYZSzLBKGhO1TgUMYQRUEGqWSCQdfAYYbRIsrkAsUS45jRSAohA0qF-5T0wO1Ot6rNZ6tsw0ttc1W4A5VpLQ_jgDLkXOqBmz3YZqWSvKp1KeoN_3fFAf4O-NaF2hznkG_d5lu3udPhyXw-dfHIa9uonwMv6g8eMsIC_vYw4eEYPyd3LOWv5A9Rj4C0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69547124</pqid></control><display><type>article</type><title>Accurate pre-operative localization of pathological parathyroid glands using 11C-methionine PET/CT</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Tang, Bich-Ngoc-Thanh ; Moreno-Reyes, Rodrigo ; Blocklet, Didier ; Corvilain, Bernard ; Cappello, Matteo ; Delpierre, Isabelle ; Devuyst, France ; Van Simaeys, Gaetan ; Goldman, Serge</creator><creatorcontrib>Tang, Bich-Ngoc-Thanh ; Moreno-Reyes, Rodrigo ; Blocklet, Didier ; Corvilain, Bernard ; Cappello, Matteo ; Delpierre, Isabelle ; Devuyst, France ; Van Simaeys, Gaetan ; Goldman, Serge</creatorcontrib><description>Objective
The pre‐operative technique most routinely used to localize pathological parathyroid glands (PPG), prior to minimal access surgery (MAS), relies on 99mTc‐sestamibi (MIBI) scintigraphy. Positron emission tomography (PET) using the radiolabelled amino acid 11C‐methionine as the tracer agent offers a technological alternative to localize PPG. In this study we evaluated the sensitivity of 11C‐methionine PET/CT (MET‐PET/CT) for PPG detection and the extent to which MET‐PET/CT images may contribute to the planning of surgical procedures.
Design
Thirty patients were included, 22 with primary hyperparathyroidism and eight with secondary hyperparathyroidism. Patients suspected of suffering from parathyroid hyperplasia underwent a complete surgical exploration of the neck region. In those suspected of parathyroid adenoma, surgery was limited to the presumed localization described by MET‐PET/CT. To specifically address the additional benefit of the MET‐PET/CT in terms of surgical planning and procedure, the surgeon classified the patients into two categories depending on the type of benefit, or the reason for the absence of benefit, occurring in each case. We also compared the sensitivity of MET‐PET/CT and MIBI scintigraphy.
Results
The total number of lesions removed was 46 (24 adenomatous and 22 hyperplastic). Globally, MET‐PET/CT provided additional benefit to surgery in 15 out of 30 cases (50%). The sensitivity of 11C‐methionine PET/CT and MIBI scintigraphy was respectively 92% and 95% for adenoma, and 68% and 59% for hyperplasia, on the basis of available resected lesions.
Conclusion
MET‐PET/CT appears a reliable technique to guide MAS of parathyroid glands. Copyright © 2008 John Wiley & Sons, Ltd.
In this study of 30 patients, we demonstrate the additional benefits of the 11C‐methionine PET/CT (MET‐PET/CT) in the pre‐surgical planning for the resection of pathological parathyroid glands. We found that MET‐PET/CT benefits to 50% of the studied cases and is as sensitive as MIBI scintigraphy, for the detection of both adenoma (95% vs. 92%) hyperplasia (68% vs. 59%). Consequently, MET‐PET/CT could be considered as a reliable technique to guide minimal access surgery of parathyroid glands.</description><identifier>ISSN: 1555-4309</identifier><identifier>EISSN: 1555-4317</identifier><identifier>DOI: 10.1002/cmmi.243</identifier><identifier>PMID: 18781582</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>11C-methionine ; Adult ; Aged ; Carbon Radioisotopes ; Humans ; Methionine ; Middle Aged ; minimal access surgery ; Parathyroid Glands - diagnostic imaging ; Parathyroid Glands - pathology ; pathological parathyroid glands ; PET/CT ; Positron-Emission Tomography - methods ; Preoperative Care - instrumentation ; Preoperative Care - methods ; Radiopharmaceuticals ; Reproducibility of Results ; Tomography, X-Ray Computed - methods</subject><ispartof>Contrast media and molecular imaging, 2008-07, Vol.3 (4), p.157-163</ispartof><rights>Copyright © 2008 John Wiley & Sons, Ltd.</rights><rights>Copyright (c) 2008 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18781582$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tang, Bich-Ngoc-Thanh</creatorcontrib><creatorcontrib>Moreno-Reyes, Rodrigo</creatorcontrib><creatorcontrib>Blocklet, Didier</creatorcontrib><creatorcontrib>Corvilain, Bernard</creatorcontrib><creatorcontrib>Cappello, Matteo</creatorcontrib><creatorcontrib>Delpierre, Isabelle</creatorcontrib><creatorcontrib>Devuyst, France</creatorcontrib><creatorcontrib>Van Simaeys, Gaetan</creatorcontrib><creatorcontrib>Goldman, Serge</creatorcontrib><title>Accurate pre-operative localization of pathological parathyroid glands using 11C-methionine PET/CT</title><title>Contrast media and molecular imaging</title><addtitle>Contrast Media Mol Imaging</addtitle><description>Objective
The pre‐operative technique most routinely used to localize pathological parathyroid glands (PPG), prior to minimal access surgery (MAS), relies on 99mTc‐sestamibi (MIBI) scintigraphy. Positron emission tomography (PET) using the radiolabelled amino acid 11C‐methionine as the tracer agent offers a technological alternative to localize PPG. In this study we evaluated the sensitivity of 11C‐methionine PET/CT (MET‐PET/CT) for PPG detection and the extent to which MET‐PET/CT images may contribute to the planning of surgical procedures.
Design
Thirty patients were included, 22 with primary hyperparathyroidism and eight with secondary hyperparathyroidism. Patients suspected of suffering from parathyroid hyperplasia underwent a complete surgical exploration of the neck region. In those suspected of parathyroid adenoma, surgery was limited to the presumed localization described by MET‐PET/CT. To specifically address the additional benefit of the MET‐PET/CT in terms of surgical planning and procedure, the surgeon classified the patients into two categories depending on the type of benefit, or the reason for the absence of benefit, occurring in each case. We also compared the sensitivity of MET‐PET/CT and MIBI scintigraphy.
Results
The total number of lesions removed was 46 (24 adenomatous and 22 hyperplastic). Globally, MET‐PET/CT provided additional benefit to surgery in 15 out of 30 cases (50%). The sensitivity of 11C‐methionine PET/CT and MIBI scintigraphy was respectively 92% and 95% for adenoma, and 68% and 59% for hyperplasia, on the basis of available resected lesions.
Conclusion
MET‐PET/CT appears a reliable technique to guide MAS of parathyroid glands. Copyright © 2008 John Wiley & Sons, Ltd.
In this study of 30 patients, we demonstrate the additional benefits of the 11C‐methionine PET/CT (MET‐PET/CT) in the pre‐surgical planning for the resection of pathological parathyroid glands. We found that MET‐PET/CT benefits to 50% of the studied cases and is as sensitive as MIBI scintigraphy, for the detection of both adenoma (95% vs. 92%) hyperplasia (68% vs. 59%). Consequently, MET‐PET/CT could be considered as a reliable technique to guide minimal access surgery of parathyroid glands.</description><subject>11C-methionine</subject><subject>Adult</subject><subject>Aged</subject><subject>Carbon Radioisotopes</subject><subject>Humans</subject><subject>Methionine</subject><subject>Middle Aged</subject><subject>minimal access surgery</subject><subject>Parathyroid Glands - diagnostic imaging</subject><subject>Parathyroid Glands - pathology</subject><subject>pathological parathyroid glands</subject><subject>PET/CT</subject><subject>Positron-Emission Tomography - methods</subject><subject>Preoperative Care - instrumentation</subject><subject>Preoperative Care - methods</subject><subject>Radiopharmaceuticals</subject><subject>Reproducibility of Results</subject><subject>Tomography, X-Ray Computed - methods</subject><issn>1555-4309</issn><issn>1555-4317</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkF1PwjAUhhujEUQTf4HZlXeDfm3dLnEBJAE1Zupl060Fqhud66bir7cEhKvz9Zw357wAXCPYRxDiQV6Wuo8pOQFdFASBTwlip4ccxh1wYe07hJSSmJyDDopYhIIId0E2zPO2Fo3yqlr5plIu11_KK0wuCv3rCrP2zMKrRLMyhVlq13aFo1ab2mjpLQuxltZrrV4vPYQSv1TNyi3ptfKeRukgSS_B2UIUVl3tYw-8jEdpcu_PHifTZDjzNYpD4ksYZSzLBKGhO1TgUMYQRUEGqWSCQdfAYYbRIsrkAsUS45jRSAohA0qF-5T0wO1Ot6rNZ6tsw0ttc1W4A5VpLQ_jgDLkXOqBmz3YZqWSvKp1KeoN_3fFAf4O-NaF2hznkG_d5lu3udPhyXw-dfHIa9uonwMv6g8eMsIC_vYw4eEYPyd3LOWv5A9Rj4C0</recordid><startdate>200807</startdate><enddate>200807</enddate><creator>Tang, Bich-Ngoc-Thanh</creator><creator>Moreno-Reyes, Rodrigo</creator><creator>Blocklet, Didier</creator><creator>Corvilain, Bernard</creator><creator>Cappello, Matteo</creator><creator>Delpierre, Isabelle</creator><creator>Devuyst, France</creator><creator>Van Simaeys, Gaetan</creator><creator>Goldman, Serge</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200807</creationdate><title>Accurate pre-operative localization of pathological parathyroid glands using 11C-methionine PET/CT</title><author>Tang, Bich-Ngoc-Thanh ; Moreno-Reyes, Rodrigo ; Blocklet, Didier ; Corvilain, Bernard ; Cappello, Matteo ; Delpierre, Isabelle ; Devuyst, France ; Van Simaeys, Gaetan ; Goldman, Serge</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i1963-d08b7bba346004a26d90185b04d7a70a2626b21f8bdf19d229748daad544a1553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>11C-methionine</topic><topic>Adult</topic><topic>Aged</topic><topic>Carbon Radioisotopes</topic><topic>Humans</topic><topic>Methionine</topic><topic>Middle Aged</topic><topic>minimal access surgery</topic><topic>Parathyroid Glands - diagnostic imaging</topic><topic>Parathyroid Glands - pathology</topic><topic>pathological parathyroid glands</topic><topic>PET/CT</topic><topic>Positron-Emission Tomography - methods</topic><topic>Preoperative Care - instrumentation</topic><topic>Preoperative Care - methods</topic><topic>Radiopharmaceuticals</topic><topic>Reproducibility of Results</topic><topic>Tomography, X-Ray Computed - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tang, Bich-Ngoc-Thanh</creatorcontrib><creatorcontrib>Moreno-Reyes, Rodrigo</creatorcontrib><creatorcontrib>Blocklet, Didier</creatorcontrib><creatorcontrib>Corvilain, Bernard</creatorcontrib><creatorcontrib>Cappello, Matteo</creatorcontrib><creatorcontrib>Delpierre, Isabelle</creatorcontrib><creatorcontrib>Devuyst, France</creatorcontrib><creatorcontrib>Van Simaeys, Gaetan</creatorcontrib><creatorcontrib>Goldman, Serge</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Contrast media and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tang, Bich-Ngoc-Thanh</au><au>Moreno-Reyes, Rodrigo</au><au>Blocklet, Didier</au><au>Corvilain, Bernard</au><au>Cappello, Matteo</au><au>Delpierre, Isabelle</au><au>Devuyst, France</au><au>Van Simaeys, Gaetan</au><au>Goldman, Serge</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Accurate pre-operative localization of pathological parathyroid glands using 11C-methionine PET/CT</atitle><jtitle>Contrast media and molecular imaging</jtitle><addtitle>Contrast Media Mol Imaging</addtitle><date>2008-07</date><risdate>2008</risdate><volume>3</volume><issue>4</issue><spage>157</spage><epage>163</epage><pages>157-163</pages><issn>1555-4309</issn><eissn>1555-4317</eissn><abstract>Objective
The pre‐operative technique most routinely used to localize pathological parathyroid glands (PPG), prior to minimal access surgery (MAS), relies on 99mTc‐sestamibi (MIBI) scintigraphy. Positron emission tomography (PET) using the radiolabelled amino acid 11C‐methionine as the tracer agent offers a technological alternative to localize PPG. In this study we evaluated the sensitivity of 11C‐methionine PET/CT (MET‐PET/CT) for PPG detection and the extent to which MET‐PET/CT images may contribute to the planning of surgical procedures.
Design
Thirty patients were included, 22 with primary hyperparathyroidism and eight with secondary hyperparathyroidism. Patients suspected of suffering from parathyroid hyperplasia underwent a complete surgical exploration of the neck region. In those suspected of parathyroid adenoma, surgery was limited to the presumed localization described by MET‐PET/CT. To specifically address the additional benefit of the MET‐PET/CT in terms of surgical planning and procedure, the surgeon classified the patients into two categories depending on the type of benefit, or the reason for the absence of benefit, occurring in each case. We also compared the sensitivity of MET‐PET/CT and MIBI scintigraphy.
Results
The total number of lesions removed was 46 (24 adenomatous and 22 hyperplastic). Globally, MET‐PET/CT provided additional benefit to surgery in 15 out of 30 cases (50%). The sensitivity of 11C‐methionine PET/CT and MIBI scintigraphy was respectively 92% and 95% for adenoma, and 68% and 59% for hyperplasia, on the basis of available resected lesions.
Conclusion
MET‐PET/CT appears a reliable technique to guide MAS of parathyroid glands. Copyright © 2008 John Wiley & Sons, Ltd.
In this study of 30 patients, we demonstrate the additional benefits of the 11C‐methionine PET/CT (MET‐PET/CT) in the pre‐surgical planning for the resection of pathological parathyroid glands. We found that MET‐PET/CT benefits to 50% of the studied cases and is as sensitive as MIBI scintigraphy, for the detection of both adenoma (95% vs. 92%) hyperplasia (68% vs. 59%). Consequently, MET‐PET/CT could be considered as a reliable technique to guide minimal access surgery of parathyroid glands.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>18781582</pmid><doi>10.1002/cmmi.243</doi><tpages>7</tpages></addata></record> |
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| subjects | 11C-methionine Adult Aged Carbon Radioisotopes Humans Methionine Middle Aged minimal access surgery Parathyroid Glands - diagnostic imaging Parathyroid Glands - pathology pathological parathyroid glands PET/CT Positron-Emission Tomography - methods Preoperative Care - instrumentation Preoperative Care - methods Radiopharmaceuticals Reproducibility of Results Tomography, X-Ray Computed - methods |
| title | Accurate pre-operative localization of pathological parathyroid glands using 11C-methionine PET/CT |
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