Binding of HMG‐I(Y) elicits structural changes in a silencer of the human β‐globin gene

Proteins involved in repression of the human β‐globin gene may be useful in the treatment of sickle cell anemia, in conjunction with therapy to reactivate fetal globin genes. If there is a reciprocal elevation of β‐globin expression upon repression, this approach could be useful in additional hemogl...

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