Cytokines and lipopolysaccharides induce inducible nitric oxide synthase but not enzyme activity in adult rat cardiomyocytes

There is evidence that nitric oxide (NO) formation in adult cardiomyocytes stimulated with lipopolysaccharide (LPS) is not commensurate with iNOS levels. Tetrahydrobiopterin (BH 4) is a key factor in the stabilization and NO production by iNOS homodimer. Thus we hypothesized that BH 4 is a limiting...

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Veröffentlicht in:	Free radical biology & medicine 2008-10, Vol.45 (7), p.994-1001
Hauptverfasser:	Vásquez-Vivar, Jeannette, Whitsett, Jennifer, Ionova, Irina, Konorev, Eugene, Zielonka, Jacek, Kalyanaraman, Balaraman, Shi, Yang, Pieper, Galen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aconitase Animals Biopterins - analogs & derivatives Biopterins - metabolism Blotting, Western Cytokines Cytokines - metabolism Gene Expression Lipopolysaccharide Lipopolysaccharides - metabolism Myocytes, Cardiac - metabolism Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type II - metabolism Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Reverse Transcriptase Polymerase Chain Reaction Tetrahydrobiopterin
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