Management of Highly Sensitized Patients: Capitol Medical Center Experience

Abstract Highly sensitized patients with elevated anti-HLA antibodies have difficulty to get a living donor due to cross-match positivity and longer waiting times for cadaveric donor transplantation. In this regard, several studies have been made to abrogate cross-match positivity for a possible suc...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Transplantation proceedings 2008-09, Vol.40 (7), p.2274-2280
Hauptverfasser:	Amante, A.J, Ejercito, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Murine-Derived Biological and medical sciences Creatinine - blood Female Fundamental and applied biological sciences. Psychology Fundamental immunology Health participants Histocompatibility Testing HLA Antigens - immunology Humans Hypersensitivity - immunology Immunoglobulins, Intravenous - therapeutic use Immunologic Factors - therapeutic use Immunosuppressive Agents - therapeutic use Isoantibodies - immunology Kidney Transplantation - immunology Living Donors Male Medical sciences Middle Aged Plasmapheresis Public health. Hygiene Public health. Hygiene-occupational medicine Rituximab Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue, organ and graft immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Abstract Highly sensitized patients with elevated anti-HLA antibodies have difficulty to get a living donor due to cross-match positivity and longer waiting times for cadaveric donor transplantation. In this regard, several studies have been made to abrogate cross-match positivity for a possible successful kidney transplantation. In this article, we report our experience, using a desensitization protocol with Rituximab monoclonal antibody complemented with intravenous immunoglubulin and/or plasmapheresis, to prepare highly sensitized patients for successful kidney transplantation.
ISSN:	0041-1345 1873-2623
DOI:	10.1016/j.transproceed.2008.07.007