Seroprevalence of Helicobacter pylori in Central-European uraemic patients and its possible association with presence of HLA-DR12 allele
OBJECTIVESRenal disease at any stage is often accompanied by significant gastrointestinal symptoms, and Helicobacter pylori (H. pylori) is closely related to these disorders. A debate is still ongoing on the clinical significance of coexisting uraemia and H. pylori. HLA-class II genes have been repe...
Gespeichert in:
| Veröffentlicht in: | European journal of gastroenterology & hepatology 2008-09, Vol.20 (9), p.906-911, Article 906 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 911 |
|---|---|
| container_issue | 9 |
| container_start_page | 906 |
| container_title | European journal of gastroenterology & hepatology |
| container_volume | 20 |
| creator | Telkes, Gábor Rajczy, Katalin Varga, Marina Péter, Antal Tulassay, Zsolt |
| description | OBJECTIVESRenal disease at any stage is often accompanied by significant gastrointestinal symptoms, and Helicobacter pylori (H. pylori) is closely related to these disorders. A debate is still ongoing on the clinical significance of coexisting uraemia and H. pylori. HLA-class II genes have been repeatedly investigated for predisposition to H. pylori infection. The aim of our work was to evaluate the infection rate among uraemic patients, and study the relationship between HLA antigens and H. pylori serologic status in the same cohort.
MATERIALS AND METHODSData of 709 uraemic patients were collected and analyzed from 2001–2006. 58.7% of patients were male, 41.3% were female, mean age was 45.1 years (SD±14.65). Microlymphocytotoxicity assay was used for typing of HLA class I, PCR-SSP for typing HLA class II alleles and enzyme immunofluorescency for specific H. pylori IgG.
RESULTSOf 709 patients, 49.37% were seropositive for H. pylori. Age of H. pylori positive patients was 48.9 versus 41 years of negatives (P |
| doi_str_mv | 10.1097/MEG.0b013e3282f824d9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69543452</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69543452</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3804-a417bcea293b38021b625d9da5cf8dd11d5e3956fc55b6153b7b258c0775bb193</originalsourceid><addsrcrecordid>eNqFUctu1DAUtRCITgt_gJA3sEvxM47ZVdNpizQIiYfELrKdG43BEwc7YdQ_6GfXbaMidcPCurLvOfdcn4PQG0pOKdHqw-fN5SmxhHLgrGF9w0Snn6EVFYpXsm7Uc7QiWoqq1vTnETrO-RchVHGqXqIj2igtaiJX6OYbpDgm-GsCDA5w7PEVBO-iNW6ChMfrEJPHfsBrGKZkQrWZCwHMgOdkYO8dHs3kSy9jM3TYlzrGnL0NgE3O0fnSjgM--GmHi1B-lNmeVedfKcMmBAjwCr3oTcjweqkn6MfF5vv6qtp-ufy0PttWjjdEVEZQZR0YprktD4zamslOd0a6vuk6SjsJXMu6d1LamkpulWWycUQpaS3V_AS9f5g7pvhnhjy1e58dhGAGiHNu6-IZF5IVoHgAulT-k6Bvx-T3Jl23lLR3CbQlgfZpAoX2dpk_2z10_0iL5QXwbgGY7Ezokxmcz484RqRqKCUF9_GJvvPTvZclBh_-t8Wy_CGGEmP-HeYDpHYHJky7lhAimOKqYoQ0RJdrVQ4V_Bb7qrO7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69543452</pqid></control><display><type>article</type><title>Seroprevalence of Helicobacter pylori in Central-European uraemic patients and its possible association with presence of HLA-DR12 allele</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Telkes, Gábor ; Rajczy, Katalin ; Varga, Marina ; Péter, Antal ; Tulassay, Zsolt</creator><creatorcontrib>Telkes, Gábor ; Rajczy, Katalin ; Varga, Marina ; Péter, Antal ; Tulassay, Zsolt</creatorcontrib><description>OBJECTIVESRenal disease at any stage is often accompanied by significant gastrointestinal symptoms, and Helicobacter pylori (H. pylori) is closely related to these disorders. A debate is still ongoing on the clinical significance of coexisting uraemia and H. pylori. HLA-class II genes have been repeatedly investigated for predisposition to H. pylori infection. The aim of our work was to evaluate the infection rate among uraemic patients, and study the relationship between HLA antigens and H. pylori serologic status in the same cohort.
MATERIALS AND METHODSData of 709 uraemic patients were collected and analyzed from 2001–2006. 58.7% of patients were male, 41.3% were female, mean age was 45.1 years (SD±14.65). Microlymphocytotoxicity assay was used for typing of HLA class I, PCR-SSP for typing HLA class II alleles and enzyme immunofluorescency for specific H. pylori IgG.
RESULTSOf 709 patients, 49.37% were seropositive for H. pylori. Age of H. pylori positive patients was 48.9 versus 41 years of negatives (P<0.0001). Prevalence of H. pylori decreased strongly with year of birth. Significant difference was observed in the occurrence of HLA-DR12 according to H. pylori serology. Of patients carrying DR12, 27 (73%) were H. pylori positive and 10 (27%) were negative [P=0.0037; risk ratios (RR)2.76].
CONCLUSIONH. pylori infection rate and its decrease with year of birth was the same in the uraemic patients and in the normal population, according to specific prevalence figures. Frequency of HLA-DR12 was the same as in the general population; consequently, it might be a possible risk factor for H. pylori seropositivity, at least in a Central-European population.</description><identifier>ISSN: 0954-691X</identifier><identifier>EISSN: 1473-5687</identifier><identifier>DOI: 10.1097/MEG.0b013e3282f824d9</identifier><identifier>PMID: 18794605</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adolescent ; Adult ; Aged ; Alleles ; Bacterial diseases ; Bacterial diseases of the digestive system and abdomen ; Biological and medical sciences ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Gene Frequency ; Genetic Predisposition to Disease ; Helicobacter Infections - complications ; Helicobacter Infections - epidemiology ; Helicobacter Infections - genetics ; Helicobacter pylori ; HLA-DR Antigens - genetics ; HLA-DR Serological Subtypes ; Human bacterial diseases ; Humans ; Hungary - epidemiology ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Opportunistic Infections - complications ; Opportunistic Infections - epidemiology ; Opportunistic Infections - genetics ; Renal failure ; Seroepidemiologic Studies ; Uremia - complications ; Uremia - epidemiology ; Uremia - genetics ; Young Adult</subject><ispartof>European journal of gastroenterology & hepatology, 2008-09, Vol.20 (9), p.906-911, Article 906</ispartof><rights>2008 Lippincott Williams & Wilkins, Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3804-a417bcea293b38021b625d9da5cf8dd11d5e3956fc55b6153b7b258c0775bb193</citedby><cites>FETCH-LOGICAL-c3804-a417bcea293b38021b625d9da5cf8dd11d5e3956fc55b6153b7b258c0775bb193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20578110$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18794605$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Telkes, Gábor</creatorcontrib><creatorcontrib>Rajczy, Katalin</creatorcontrib><creatorcontrib>Varga, Marina</creatorcontrib><creatorcontrib>Péter, Antal</creatorcontrib><creatorcontrib>Tulassay, Zsolt</creatorcontrib><title>Seroprevalence of Helicobacter pylori in Central-European uraemic patients and its possible association with presence of HLA-DR12 allele</title><title>European journal of gastroenterology & hepatology</title><addtitle>Eur J Gastroenterol Hepatol</addtitle><description>OBJECTIVESRenal disease at any stage is often accompanied by significant gastrointestinal symptoms, and Helicobacter pylori (H. pylori) is closely related to these disorders. A debate is still ongoing on the clinical significance of coexisting uraemia and H. pylori. HLA-class II genes have been repeatedly investigated for predisposition to H. pylori infection. The aim of our work was to evaluate the infection rate among uraemic patients, and study the relationship between HLA antigens and H. pylori serologic status in the same cohort.
MATERIALS AND METHODSData of 709 uraemic patients were collected and analyzed from 2001–2006. 58.7% of patients were male, 41.3% were female, mean age was 45.1 years (SD±14.65). Microlymphocytotoxicity assay was used for typing of HLA class I, PCR-SSP for typing HLA class II alleles and enzyme immunofluorescency for specific H. pylori IgG.
RESULTSOf 709 patients, 49.37% were seropositive for H. pylori. Age of H. pylori positive patients was 48.9 versus 41 years of negatives (P<0.0001). Prevalence of H. pylori decreased strongly with year of birth. Significant difference was observed in the occurrence of HLA-DR12 according to H. pylori serology. Of patients carrying DR12, 27 (73%) were H. pylori positive and 10 (27%) were negative [P=0.0037; risk ratios (RR)2.76].
CONCLUSIONH. pylori infection rate and its decrease with year of birth was the same in the uraemic patients and in the normal population, according to specific prevalence figures. Frequency of HLA-DR12 was the same as in the general population; consequently, it might be a possible risk factor for H. pylori seropositivity, at least in a Central-European population.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the digestive system and abdomen</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Helicobacter Infections - complications</subject><subject>Helicobacter Infections - epidemiology</subject><subject>Helicobacter Infections - genetics</subject><subject>Helicobacter pylori</subject><subject>HLA-DR Antigens - genetics</subject><subject>HLA-DR Serological Subtypes</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Hungary - epidemiology</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Opportunistic Infections - complications</subject><subject>Opportunistic Infections - epidemiology</subject><subject>Opportunistic Infections - genetics</subject><subject>Renal failure</subject><subject>Seroepidemiologic Studies</subject><subject>Uremia - complications</subject><subject>Uremia - epidemiology</subject><subject>Uremia - genetics</subject><subject>Young Adult</subject><issn>0954-691X</issn><issn>1473-5687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctu1DAUtRCITgt_gJA3sEvxM47ZVdNpizQIiYfELrKdG43BEwc7YdQ_6GfXbaMidcPCurLvOfdcn4PQG0pOKdHqw-fN5SmxhHLgrGF9w0Snn6EVFYpXsm7Uc7QiWoqq1vTnETrO-RchVHGqXqIj2igtaiJX6OYbpDgm-GsCDA5w7PEVBO-iNW6ChMfrEJPHfsBrGKZkQrWZCwHMgOdkYO8dHs3kSy9jM3TYlzrGnL0NgE3O0fnSjgM--GmHi1B-lNmeVedfKcMmBAjwCr3oTcjweqkn6MfF5vv6qtp-ufy0PttWjjdEVEZQZR0YprktD4zamslOd0a6vuk6SjsJXMu6d1LamkpulWWycUQpaS3V_AS9f5g7pvhnhjy1e58dhGAGiHNu6-IZF5IVoHgAulT-k6Bvx-T3Jl23lLR3CbQlgfZpAoX2dpk_2z10_0iL5QXwbgGY7Ezokxmcz484RqRqKCUF9_GJvvPTvZclBh_-t8Wy_CGGEmP-HeYDpHYHJky7lhAimOKqYoQ0RJdrVQ4V_Bb7qrO7</recordid><startdate>200809</startdate><enddate>200809</enddate><creator>Telkes, Gábor</creator><creator>Rajczy, Katalin</creator><creator>Varga, Marina</creator><creator>Péter, Antal</creator><creator>Tulassay, Zsolt</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200809</creationdate><title>Seroprevalence of Helicobacter pylori in Central-European uraemic patients and its possible association with presence of HLA-DR12 allele</title><author>Telkes, Gábor ; Rajczy, Katalin ; Varga, Marina ; Péter, Antal ; Tulassay, Zsolt</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3804-a417bcea293b38021b625d9da5cf8dd11d5e3956fc55b6153b7b258c0775bb193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Alleles</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the digestive system and abdomen</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Helicobacter Infections - complications</topic><topic>Helicobacter Infections - epidemiology</topic><topic>Helicobacter Infections - genetics</topic><topic>Helicobacter pylori</topic><topic>HLA-DR Antigens - genetics</topic><topic>HLA-DR Serological Subtypes</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Hungary - epidemiology</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Opportunistic Infections - complications</topic><topic>Opportunistic Infections - epidemiology</topic><topic>Opportunistic Infections - genetics</topic><topic>Renal failure</topic><topic>Seroepidemiologic Studies</topic><topic>Uremia - complications</topic><topic>Uremia - epidemiology</topic><topic>Uremia - genetics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Telkes, Gábor</creatorcontrib><creatorcontrib>Rajczy, Katalin</creatorcontrib><creatorcontrib>Varga, Marina</creatorcontrib><creatorcontrib>Péter, Antal</creatorcontrib><creatorcontrib>Tulassay, Zsolt</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of gastroenterology & hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Telkes, Gábor</au><au>Rajczy, Katalin</au><au>Varga, Marina</au><au>Péter, Antal</au><au>Tulassay, Zsolt</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Seroprevalence of Helicobacter pylori in Central-European uraemic patients and its possible association with presence of HLA-DR12 allele</atitle><jtitle>European journal of gastroenterology & hepatology</jtitle><addtitle>Eur J Gastroenterol Hepatol</addtitle><date>2008-09</date><risdate>2008</risdate><volume>20</volume><issue>9</issue><spage>906</spage><epage>911</epage><pages>906-911</pages><artnum>906</artnum><issn>0954-691X</issn><eissn>1473-5687</eissn><abstract>OBJECTIVESRenal disease at any stage is often accompanied by significant gastrointestinal symptoms, and Helicobacter pylori (H. pylori) is closely related to these disorders. A debate is still ongoing on the clinical significance of coexisting uraemia and H. pylori. HLA-class II genes have been repeatedly investigated for predisposition to H. pylori infection. The aim of our work was to evaluate the infection rate among uraemic patients, and study the relationship between HLA antigens and H. pylori serologic status in the same cohort.
MATERIALS AND METHODSData of 709 uraemic patients were collected and analyzed from 2001–2006. 58.7% of patients were male, 41.3% were female, mean age was 45.1 years (SD±14.65). Microlymphocytotoxicity assay was used for typing of HLA class I, PCR-SSP for typing HLA class II alleles and enzyme immunofluorescency for specific H. pylori IgG.
RESULTSOf 709 patients, 49.37% were seropositive for H. pylori. Age of H. pylori positive patients was 48.9 versus 41 years of negatives (P<0.0001). Prevalence of H. pylori decreased strongly with year of birth. Significant difference was observed in the occurrence of HLA-DR12 according to H. pylori serology. Of patients carrying DR12, 27 (73%) were H. pylori positive and 10 (27%) were negative [P=0.0037; risk ratios (RR)2.76].
CONCLUSIONH. pylori infection rate and its decrease with year of birth was the same in the uraemic patients and in the normal population, according to specific prevalence figures. Frequency of HLA-DR12 was the same as in the general population; consequently, it might be a possible risk factor for H. pylori seropositivity, at least in a Central-European population.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>18794605</pmid><doi>10.1097/MEG.0b013e3282f824d9</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-691X |
| ispartof | European journal of gastroenterology & hepatology, 2008-09, Vol.20 (9), p.906-911, Article 906 |
| issn | 0954-691X 1473-5687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69543452 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Adult Aged Alleles Bacterial diseases Bacterial diseases of the digestive system and abdomen Biological and medical sciences Child Child, Preschool Cross-Sectional Studies Female Gastroenterology. Liver. Pancreas. Abdomen Gene Frequency Genetic Predisposition to Disease Helicobacter Infections - complications Helicobacter Infections - epidemiology Helicobacter Infections - genetics Helicobacter pylori HLA-DR Antigens - genetics HLA-DR Serological Subtypes Human bacterial diseases Humans Hungary - epidemiology Infectious diseases Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Opportunistic Infections - complications Opportunistic Infections - epidemiology Opportunistic Infections - genetics Renal failure Seroepidemiologic Studies Uremia - complications Uremia - epidemiology Uremia - genetics Young Adult |
| title | Seroprevalence of Helicobacter pylori in Central-European uraemic patients and its possible association with presence of HLA-DR12 allele |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T18%3A35%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Seroprevalence%20of%20Helicobacter%20pylori%20in%20Central-European%20uraemic%20patients%20and%20its%20possible%20association%20with%20presence%20of%20HLA-DR12%20allele&rft.jtitle=European%20journal%20of%20gastroenterology%20&%20hepatology&rft.au=Telkes,%20G%C3%A1bor&rft.date=2008-09&rft.volume=20&rft.issue=9&rft.spage=906&rft.epage=911&rft.pages=906-911&rft.artnum=906&rft.issn=0954-691X&rft.eissn=1473-5687&rft_id=info:doi/10.1097/MEG.0b013e3282f824d9&rft_dat=%3Cproquest_cross%3E69543452%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69543452&rft_id=info:pmid/18794605&rfr_iscdi=true |