Obesity and Age of First Non–ST-Segment Elevation Myocardial Infarction
Obesity and Age of First Non–ST-Segment Elevation Myocardial Infarction Mohan C. Madala, Barry A. Franklin, Anita Y. Chen, Aaron D. Berman, Matthew T. Roe, Eric D. Peterson, E. Magnus Ohman, Sidney C. Smith, Jr, W. Brian Gibler, Peter A. McCullough, for the CRUSADE Investigators Because excess adipo...
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| Veröffentlicht in: | Journal of the American College of Cardiology 2008-09, Vol.52 (12), p.979-985 |
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| creator | Madala, Mohan C., MD Franklin, Barry A., PhD Chen, Anita Y., MS Berman, Aaron D., MD, FACC Roe, Matthew T., MD Peterson, Eric D., MD, FACC Ohman, E. Magnus, MD, FACC Smith, Sidney C., MD, FACC Gibler, W. Brian, MD McCullough, Peter A., MD, FACC |
| description | Obesity and Age of First Non–ST-Segment Elevation Myocardial Infarction Mohan C. Madala, Barry A. Franklin, Anita Y. Chen, Aaron D. Berman, Matthew T. Roe, Eric D. Peterson, E. Magnus Ohman, Sidney C. Smith, Jr, W. Brian Gibler, Peter A. McCullough, for the CRUSADE Investigators Because excess adiposity is one of the most important determinants of adipokines and inflammatory factors associated with coronary plaque rupture, we hypothesized that obesity was associated with myocardial infarction at earlier ages. We retrospectively examined the relationship of body mass index (BMI) with patient age of first non–ST-segment elevation myocardial infarction (NSTEMI) in the CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes with Early Implementation of the American College of Cardiology/American Heart Association Guidelines) registry. The age of first NSTEMI occurred 3.5, 6.8, 9.4, and 12.0 years earlier with ascending levels of adiposity (BMI 25.1 to 30.0, 30.1 to 35.0, 35.1 to 40.0, and >40.0 kg/m2 , respectively; referent 18.6 to 25.0 kg/m2 ); p < 0.0001 for each estimate. These data suggest that as the obesity pandemic worsens, NSTEMI might occur at increasingly younger ages. |
| doi_str_mv | 10.1016/j.jacc.2008.04.067 |
| format | Article |
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Magnus, MD, FACC ; Smith, Sidney C., MD, FACC ; Gibler, W. Brian, MD ; McCullough, Peter A., MD, FACC</creator><creatorcontrib>Madala, Mohan C., MD ; Franklin, Barry A., PhD ; Chen, Anita Y., MS ; Berman, Aaron D., MD, FACC ; Roe, Matthew T., MD ; Peterson, Eric D., MD, FACC ; Ohman, E. Magnus, MD, FACC ; Smith, Sidney C., MD, FACC ; Gibler, W. Brian, MD ; McCullough, Peter A., MD, FACC ; CRUSADE Investigators</creatorcontrib><description>Obesity and Age of First Non–ST-Segment Elevation Myocardial Infarction Mohan C. Madala, Barry A. Franklin, Anita Y. Chen, Aaron D. Berman, Matthew T. Roe, Eric D. Peterson, E. Magnus Ohman, Sidney C. Smith, Jr, W. Brian Gibler, Peter A. McCullough, for the CRUSADE Investigators Because excess adiposity is one of the most important determinants of adipokines and inflammatory factors associated with coronary plaque rupture, we hypothesized that obesity was associated with myocardial infarction at earlier ages. We retrospectively examined the relationship of body mass index (BMI) with patient age of first non–ST-segment elevation myocardial infarction (NSTEMI) in the CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes with Early Implementation of the American College of Cardiology/American Heart Association Guidelines) registry. The age of first NSTEMI occurred 3.5, 6.8, 9.4, and 12.0 years earlier with ascending levels of adiposity (BMI 25.1 to 30.0, 30.1 to 35.0, 35.1 to 40.0, and >40.0 kg/m2 , respectively; referent 18.6 to 25.0 kg/m2 ); p < 0.0001 for each estimate. These data suggest that as the obesity pandemic worsens, NSTEMI might occur at increasingly younger ages.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2008.04.067</identifier><identifier>PMID: 18786477</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>acute coronary syndromes ; age ; Age of Onset ; Aged ; Aged, 80 and over ; Body Mass Index ; Cardiology ; Cardiovascular ; Cholesterol ; Coronary vessels ; Drug therapy ; Female ; Heart attacks ; Humans ; Internal Medicine ; Male ; Middle Aged ; myocardial infarction ; Myocardial Infarction - epidemiology ; Myocardial Infarction - etiology ; Obesity ; Obesity - complications ; Obesity - epidemiology ; Retrospective Studies ; Risk Factors ; United States - epidemiology</subject><ispartof>Journal of the American College of Cardiology, 2008-09, Vol.52 (12), p.979-985</ispartof><rights>American College of Cardiology Foundation</rights><rights>2008 American College of Cardiology Foundation</rights><rights>Copyright Elsevier Limited Sep 16, 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c582t-98a3d1e78a67044180618ccbb935143260f88f8f04addbdf7b9c458450073f33</citedby><cites>FETCH-LOGICAL-c582t-98a3d1e78a67044180618ccbb935143260f88f8f04addbdf7b9c458450073f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jacc.2008.04.067$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18786477$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Madala, Mohan C., MD</creatorcontrib><creatorcontrib>Franklin, Barry A., PhD</creatorcontrib><creatorcontrib>Chen, Anita Y., MS</creatorcontrib><creatorcontrib>Berman, Aaron D., MD, FACC</creatorcontrib><creatorcontrib>Roe, Matthew T., MD</creatorcontrib><creatorcontrib>Peterson, Eric D., MD, FACC</creatorcontrib><creatorcontrib>Ohman, E. Magnus, MD, FACC</creatorcontrib><creatorcontrib>Smith, Sidney C., MD, FACC</creatorcontrib><creatorcontrib>Gibler, W. Brian, MD</creatorcontrib><creatorcontrib>McCullough, Peter A., MD, FACC</creatorcontrib><creatorcontrib>CRUSADE Investigators</creatorcontrib><title>Obesity and Age of First Non–ST-Segment Elevation Myocardial Infarction</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>Obesity and Age of First Non–ST-Segment Elevation Myocardial Infarction Mohan C. Madala, Barry A. Franklin, Anita Y. Chen, Aaron D. Berman, Matthew T. Roe, Eric D. Peterson, E. Magnus Ohman, Sidney C. Smith, Jr, W. Brian Gibler, Peter A. McCullough, for the CRUSADE Investigators Because excess adiposity is one of the most important determinants of adipokines and inflammatory factors associated with coronary plaque rupture, we hypothesized that obesity was associated with myocardial infarction at earlier ages. We retrospectively examined the relationship of body mass index (BMI) with patient age of first non–ST-segment elevation myocardial infarction (NSTEMI) in the CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes with Early Implementation of the American College of Cardiology/American Heart Association Guidelines) registry. The age of first NSTEMI occurred 3.5, 6.8, 9.4, and 12.0 years earlier with ascending levels of adiposity (BMI 25.1 to 30.0, 30.1 to 35.0, 35.1 to 40.0, and >40.0 kg/m2 , respectively; referent 18.6 to 25.0 kg/m2 ); p < 0.0001 for each estimate. These data suggest that as the obesity pandemic worsens, NSTEMI might occur at increasingly younger ages.</description><subject>acute coronary syndromes</subject><subject>age</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Body Mass Index</subject><subject>Cardiology</subject><subject>Cardiovascular</subject><subject>Cholesterol</subject><subject>Coronary vessels</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>myocardial infarction</subject><subject>Myocardial Infarction - epidemiology</subject><subject>Myocardial Infarction - etiology</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - epidemiology</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>United States - epidemiology</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1q3DAURkVpaaZpX6CLYihkZ_fK-odSCCFpB9JmMbMXsnwd5HrkVPIEZtd36Bv2SWozA4EsuhJczvehey4h7ylUFKj81Fe9876qAXQFvAKpXpAVFUKXTBj1kqxAMVFSMOqMvMm5BwCpqXlNzqhWWnKlVmR912AO06FwsS0u77EYu-ImpDwVP8b49_efzbbc4P0O41RcD_jopjDG4vth9C61wQ3FOnYu-WX6lrzq3JDx3ek9J9ub6-3Vt_L27uv66vK29ELXU2m0Yy1FpZ1UwDnVIKn2vmkME5SzWkKndac74K5tm7ZTjfFcaC5g3qZj7JxcHGsf0vhrj3myu5A9DoOLOO6zlUZwKkw9gx-fgf24T3H-mqVyrqOacTNT9ZHyacw5YWcfUti5dLAU7GLZ9naxbBfLFridLc-hD6fqfbPD9ily0joDn48AziIeAyabfcDosQ0J_WTbMfy__8uzuB9CDN4NP_GA-WkPm2sLdrPceTkzaKhrEIL9A_EJoTE</recordid><startdate>20080916</startdate><enddate>20080916</enddate><creator>Madala, Mohan C., MD</creator><creator>Franklin, Barry A., PhD</creator><creator>Chen, Anita Y., MS</creator><creator>Berman, Aaron D., MD, FACC</creator><creator>Roe, Matthew T., MD</creator><creator>Peterson, Eric D., MD, FACC</creator><creator>Ohman, E. Magnus, MD, FACC</creator><creator>Smith, Sidney C., MD, FACC</creator><creator>Gibler, W. Brian, MD</creator><creator>McCullough, Peter A., MD, FACC</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20080916</creationdate><title>Obesity and Age of First Non–ST-Segment Elevation Myocardial Infarction</title><author>Madala, Mohan C., MD ; Franklin, Barry A., PhD ; Chen, Anita Y., MS ; Berman, Aaron D., MD, FACC ; Roe, Matthew T., MD ; Peterson, Eric D., MD, FACC ; Ohman, E. Magnus, MD, FACC ; Smith, Sidney C., MD, FACC ; Gibler, W. 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Magnus, MD, FACC</au><au>Smith, Sidney C., MD, FACC</au><au>Gibler, W. Brian, MD</au><au>McCullough, Peter A., MD, FACC</au><aucorp>CRUSADE Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obesity and Age of First Non–ST-Segment Elevation Myocardial Infarction</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2008-09-16</date><risdate>2008</risdate><volume>52</volume><issue>12</issue><spage>979</spage><epage>985</epage><pages>979-985</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><abstract>Obesity and Age of First Non–ST-Segment Elevation Myocardial Infarction Mohan C. Madala, Barry A. Franklin, Anita Y. Chen, Aaron D. Berman, Matthew T. Roe, Eric D. Peterson, E. Magnus Ohman, Sidney C. Smith, Jr, W. Brian Gibler, Peter A. McCullough, for the CRUSADE Investigators Because excess adiposity is one of the most important determinants of adipokines and inflammatory factors associated with coronary plaque rupture, we hypothesized that obesity was associated with myocardial infarction at earlier ages. We retrospectively examined the relationship of body mass index (BMI) with patient age of first non–ST-segment elevation myocardial infarction (NSTEMI) in the CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes with Early Implementation of the American College of Cardiology/American Heart Association Guidelines) registry. The age of first NSTEMI occurred 3.5, 6.8, 9.4, and 12.0 years earlier with ascending levels of adiposity (BMI 25.1 to 30.0, 30.1 to 35.0, 35.1 to 40.0, and >40.0 kg/m2 , respectively; referent 18.6 to 25.0 kg/m2 ); p < 0.0001 for each estimate. These data suggest that as the obesity pandemic worsens, NSTEMI might occur at increasingly younger ages.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>18786477</pmid><doi>10.1016/j.jacc.2008.04.067</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | acute coronary syndromes age Age of Onset Aged Aged, 80 and over Body Mass Index Cardiology Cardiovascular Cholesterol Coronary vessels Drug therapy Female Heart attacks Humans Internal Medicine Male Middle Aged myocardial infarction Myocardial Infarction - epidemiology Myocardial Infarction - etiology Obesity Obesity - complications Obesity - epidemiology Retrospective Studies Risk Factors United States - epidemiology |
| title | Obesity and Age of First Non–ST-Segment Elevation Myocardial Infarction |
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