Androgens Alter the Cytokine Profile and Reduce Encephalitogenicity of Myelin-Reactive T Cells

Adoptive transfer of proteolipid protein 139-151-specific T cell lines was used to examine the role of androgens in regulating T cell cytokine secretion and the severity of experimental autoimmune encephalomyelitis (EAE) in the SJL mouse. In this study, we found that T cells from female mice transfe...

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Veröffentlicht in:	The Journal of immunology (1950) 1999-01, Vol.162 (1), p.35-40
Hauptverfasser:	Bebo, Bruce F., Jr, Schuster, Jeanette C, Vandenbark, Arthur A, Offner, Halina
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Androgens - physiology Animals CD4-Positive T-Lymphocytes - metabolism Cell Line Cell Separation Cytokines - biosynthesis Cytokines - secretion Encephalomyelitis, Autoimmune, Experimental - etiology Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - metabolism Female Macrophages - metabolism Male Mice Mice, Inbred C57BL Mice, Inbred Strains Mice, Transgenic Myelin Proteins - immunology Receptors, Androgen - biosynthesis Receptors, Androgen - genetics Receptors, Estrogen - biosynthesis Receptors, Estrogen - genetics RNA, Messenger - biosynthesis Sex Characteristics T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - secretion T-Lymphocyte Subsets - transplantation
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