Effects of high‐frequency stimulation on epileptiform activity in vitro: ON/OFF control paradigm
Summary Purpose: To determine the effects of high‐frequency electrical stimulation on electrographic seizure activity during and after stimulation (ON‐effect and OFF‐effect). Methods: The modulation and suppression of epileptiform activity during (ON‐effect) and after (OFF‐effect) high‐frequency ele...
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| Veröffentlicht in: | Epilepsia (Copenhagen) 2008-09, Vol.49 (9), p.1586-1593 |
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| creator | Su, Yuzhuo Radman, Thomas Vaynshteyn, Jake Parra, Lucas C. Bikson, Marom |
| description | Summary
Purpose: To determine the effects of high‐frequency electrical stimulation on electrographic seizure activity during and after stimulation (ON‐effect and OFF‐effect).
Methods: The modulation and suppression of epileptiform activity during (ON‐effect) and after (OFF‐effect) high‐frequency electrical stimulation was investigated using the high‐K+ and picrotoxin hippocampal slice epilepsy models. Uniform sinusoidal fields (50 Hz) were applied with various intensity levels for 1 min across brain slices. Extracellular and intracellular activity were monitored during and after stimulation.
Results: The ON‐effects of high‐frequency stimulation were highly variable across individual slices and models; ON‐effects included modulation of activity, pacing, partial suppression, or activity resembling spreading‐depression. On average, epileptic activity, measured as power in the extracellular fields, increased significantly during stimulation. Following the termination of electrical stimulation, a robust poststimulation suppression period was observed. This OFF suppression was observed even at relatively moderate stimulation intensities. The duration of OFF suppression increased with stimulation intensity, independent of ON‐effects. Antagonism of GABA
A
function did not directly effect OFF suppression duration.
Conclusions: The present results suggest that “rational” seizure control protocols using intermittent high‐frequency electrical stimulation should control for both ON and OFF effects. |
| doi_str_mv | 10.1111/j.1528-1167.2008.01592.x |
| format | Article |
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Purpose: To determine the effects of high‐frequency electrical stimulation on electrographic seizure activity during and after stimulation (ON‐effect and OFF‐effect).
Methods: The modulation and suppression of epileptiform activity during (ON‐effect) and after (OFF‐effect) high‐frequency electrical stimulation was investigated using the high‐K+ and picrotoxin hippocampal slice epilepsy models. Uniform sinusoidal fields (50 Hz) were applied with various intensity levels for 1 min across brain slices. Extracellular and intracellular activity were monitored during and after stimulation.
Results: The ON‐effects of high‐frequency stimulation were highly variable across individual slices and models; ON‐effects included modulation of activity, pacing, partial suppression, or activity resembling spreading‐depression. On average, epileptic activity, measured as power in the extracellular fields, increased significantly during stimulation. Following the termination of electrical stimulation, a robust poststimulation suppression period was observed. This OFF suppression was observed even at relatively moderate stimulation intensities. The duration of OFF suppression increased with stimulation intensity, independent of ON‐effects. Antagonism of GABA
A
function did not directly effect OFF suppression duration.
Conclusions: The present results suggest that “rational” seizure control protocols using intermittent high‐frequency electrical stimulation should control for both ON and OFF effects.</description><identifier>ISSN: 0013-9580</identifier><identifier>EISSN: 1528-1167</identifier><identifier>DOI: 10.1111/j.1528-1167.2008.01592.x</identifier><identifier>PMID: 18397296</identifier><identifier>CODEN: EPILAK</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Animals ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Biological and medical sciences ; CA1 ; CA3 ; Electric fields ; Electric Stimulation - instrumentation ; Electric Stimulation - methods ; Electrical stimulation ; Epilepsy ; Epilepsy - diagnosis ; Epilepsy - physiopathology ; Epilepsy - therapy ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Hippocampus ; Hippocampus - physiopathology ; Ictal ; In Vitro Techniques ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurology ; Neuropharmacology ; Pharmacology. Drug treatments ; Pyramidal Cells - physiology ; Rats ; Rats, Sprague-Dawley ; Severity of Illness Index</subject><ispartof>Epilepsia (Copenhagen), 2008-09, Vol.49 (9), p.1586-1593</ispartof><rights>2008 International League Against Epilepsy</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4782-5ecfaa25e06088c06d8534aa297b622cf0ca10bacecffdbae5989aa4d7bd89f83</citedby><cites>FETCH-LOGICAL-c4782-5ecfaa25e06088c06d8534aa297b622cf0ca10bacecffdbae5989aa4d7bd89f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1528-1167.2008.01592.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1528-1167.2008.01592.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20647407$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18397296$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Su, Yuzhuo</creatorcontrib><creatorcontrib>Radman, Thomas</creatorcontrib><creatorcontrib>Vaynshteyn, Jake</creatorcontrib><creatorcontrib>Parra, Lucas C.</creatorcontrib><creatorcontrib>Bikson, Marom</creatorcontrib><title>Effects of high‐frequency stimulation on epileptiform activity in vitro: ON/OFF control paradigm</title><title>Epilepsia (Copenhagen)</title><addtitle>Epilepsia</addtitle><description>Summary
Purpose: To determine the effects of high‐frequency electrical stimulation on electrographic seizure activity during and after stimulation (ON‐effect and OFF‐effect).
Methods: The modulation and suppression of epileptiform activity during (ON‐effect) and after (OFF‐effect) high‐frequency electrical stimulation was investigated using the high‐K+ and picrotoxin hippocampal slice epilepsy models. Uniform sinusoidal fields (50 Hz) were applied with various intensity levels for 1 min across brain slices. Extracellular and intracellular activity were monitored during and after stimulation.
Results: The ON‐effects of high‐frequency stimulation were highly variable across individual slices and models; ON‐effects included modulation of activity, pacing, partial suppression, or activity resembling spreading‐depression. On average, epileptic activity, measured as power in the extracellular fields, increased significantly during stimulation. Following the termination of electrical stimulation, a robust poststimulation suppression period was observed. This OFF suppression was observed even at relatively moderate stimulation intensities. The duration of OFF suppression increased with stimulation intensity, independent of ON‐effects. Antagonism of GABA
A
function did not directly effect OFF suppression duration.
Conclusions: The present results suggest that “rational” seizure control protocols using intermittent high‐frequency electrical stimulation should control for both ON and OFF effects.</description><subject>Animals</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Biological and medical sciences</subject><subject>CA1</subject><subject>CA3</subject><subject>Electric fields</subject><subject>Electric Stimulation - instrumentation</subject><subject>Electric Stimulation - methods</subject><subject>Electrical stimulation</subject><subject>Epilepsy</subject><subject>Epilepsy - diagnosis</subject><subject>Epilepsy - physiopathology</subject><subject>Epilepsy - therapy</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Hippocampus</subject><subject>Hippocampus - physiopathology</subject><subject>Ictal</subject><subject>In Vitro Techniques</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Pyramidal Cells - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Severity of Illness Index</subject><issn>0013-9580</issn><issn>1528-1167</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9u3CAQxlHUKtkmeYWIS3uzM2BjoFIPVbSbRoq6PTRnhDEkrPyv4E2ytz5CnzFPUtxdpccWIQ0Dv2Hg-xDCBHKSxuUmJ4yKjJCK5xRA5ECYpPnzEVq8HrxBCwBSZJIJOEHvYtwAAK94cYxOiCgkp7JaoHrpnDVTxIPDD_7-4eXnLxfsj63tzQ7HyXfbVk9-6HGadvStHSfvhtBhbSb_6Kcd9j1OMQwf8frr5Xq1wmboU9riUQfd-PvuDL11uo32_BBP0d1q-f3qS3a7vr65-nybmZILmjFrnNaUWahACANVI1hRph3J64pS48BoArU2iXNNrS2TQmpdNrxuhHSiOEUf9veOYUgfiJPqfDS2bXVvh21UlWSFLAvyT5CC5Ek0lkCxB00YYgzWqTH4ToedIqBmI9RGzXqrWW81G6H-GKGeU-nFoce27mzzt_CgfALeHwAdjW5d0L3x8ZWjUJW8BJ64T3vuKYm_--8HqOW3m3lV_AaTE6aT</recordid><startdate>200809</startdate><enddate>200809</enddate><creator>Su, Yuzhuo</creator><creator>Radman, Thomas</creator><creator>Vaynshteyn, Jake</creator><creator>Parra, Lucas C.</creator><creator>Bikson, Marom</creator><general>Blackwell Publishing Inc</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200809</creationdate><title>Effects of high‐frequency stimulation on epileptiform activity in vitro: ON/OFF control paradigm</title><author>Su, Yuzhuo ; Radman, Thomas ; Vaynshteyn, Jake ; Parra, Lucas C. ; Bikson, Marom</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4782-5ecfaa25e06088c06d8534aa297b622cf0ca10bacecffdbae5989aa4d7bd89f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>Biological and medical sciences</topic><topic>CA1</topic><topic>CA3</topic><topic>Electric fields</topic><topic>Electric Stimulation - instrumentation</topic><topic>Electric Stimulation - methods</topic><topic>Electrical stimulation</topic><topic>Epilepsy</topic><topic>Epilepsy - diagnosis</topic><topic>Epilepsy - physiopathology</topic><topic>Epilepsy - therapy</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Hippocampus</topic><topic>Hippocampus - physiopathology</topic><topic>Ictal</topic><topic>In Vitro Techniques</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyramidal Cells - physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Su, Yuzhuo</creatorcontrib><creatorcontrib>Radman, Thomas</creatorcontrib><creatorcontrib>Vaynshteyn, Jake</creatorcontrib><creatorcontrib>Parra, Lucas C.</creatorcontrib><creatorcontrib>Bikson, Marom</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Epilepsia (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Su, Yuzhuo</au><au>Radman, Thomas</au><au>Vaynshteyn, Jake</au><au>Parra, Lucas C.</au><au>Bikson, Marom</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of high‐frequency stimulation on epileptiform activity in vitro: ON/OFF control paradigm</atitle><jtitle>Epilepsia (Copenhagen)</jtitle><addtitle>Epilepsia</addtitle><date>2008-09</date><risdate>2008</risdate><volume>49</volume><issue>9</issue><spage>1586</spage><epage>1593</epage><pages>1586-1593</pages><issn>0013-9580</issn><eissn>1528-1167</eissn><coden>EPILAK</coden><abstract>Summary
Purpose: To determine the effects of high‐frequency electrical stimulation on electrographic seizure activity during and after stimulation (ON‐effect and OFF‐effect).
Methods: The modulation and suppression of epileptiform activity during (ON‐effect) and after (OFF‐effect) high‐frequency electrical stimulation was investigated using the high‐K+ and picrotoxin hippocampal slice epilepsy models. Uniform sinusoidal fields (50 Hz) were applied with various intensity levels for 1 min across brain slices. Extracellular and intracellular activity were monitored during and after stimulation.
Results: The ON‐effects of high‐frequency stimulation were highly variable across individual slices and models; ON‐effects included modulation of activity, pacing, partial suppression, or activity resembling spreading‐depression. On average, epileptic activity, measured as power in the extracellular fields, increased significantly during stimulation. Following the termination of electrical stimulation, a robust poststimulation suppression period was observed. This OFF suppression was observed even at relatively moderate stimulation intensities. The duration of OFF suppression increased with stimulation intensity, independent of ON‐effects. Antagonism of GABA
A
function did not directly effect OFF suppression duration.
Conclusions: The present results suggest that “rational” seizure control protocols using intermittent high‐frequency electrical stimulation should control for both ON and OFF effects.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>18397296</pmid><doi>10.1111/j.1528-1167.2008.01592.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Journals; Wiley Free Content; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences CA1 CA3 Electric fields Electric Stimulation - instrumentation Electric Stimulation - methods Electrical stimulation Epilepsy Epilepsy - diagnosis Epilepsy - physiopathology Epilepsy - therapy Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hippocampus Hippocampus - physiopathology Ictal In Vitro Techniques Medical sciences Nervous system (semeiology, syndromes) Neurology Neuropharmacology Pharmacology. Drug treatments Pyramidal Cells - physiology Rats Rats, Sprague-Dawley Severity of Illness Index |
| title | Effects of high‐frequency stimulation on epileptiform activity in vitro: ON/OFF control paradigm |
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