Normal IgG and Impaired IgM Responses to Polysaccharide Vaccines in Asplenic Patients
Asplenic patients are at increased risk for life-threatening infections with polysaccharide-encapsulated organisms, and reports of responses to polysaccharide vaccines have been conflicting. Thirty-six asplenic patients and 15 healthy controls were immunized with pneumococcal, Haemophilus influenzae...
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| Veröffentlicht in: | The Journal of infectious diseases 1999-02, Vol.179 (2), p.513-517 |
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| container_title | The Journal of infectious diseases |
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| creator | Molrine, Deborah C. Siber, George R. Samra, Yecheskel Shevy, Drora Samra MacDonald, Kristin Cieri, Rocco Ambrosino, Donna M. |
| description | Asplenic patients are at increased risk for life-threatening infections with polysaccharide-encapsulated organisms, and reports of responses to polysaccharide vaccines have been conflicting. Thirty-six asplenic patients and 15 healthy controls were immunized with pneumococcal, Haemophilus influenzae type b (Hib), and meningococcal vaccines. Antibody concentrations to Hib and pneumococcal serotypes 14 and 18C were measured by ELISA. IgG antibody responses to all three antigens were similar in asplenic patients and controls at 28 days following immunization. In contrast, asplenic patients had significantly lower IgM concentrations in response to Hib (P |
| doi_str_mv | 10.1086/314582 |
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Thirty-six asplenic patients and 15 healthy controls were immunized with pneumococcal, Haemophilus influenzae type b (Hib), and meningococcal vaccines. Antibody concentrations to Hib and pneumococcal serotypes 14 and 18C were measured by ELISA. IgG antibody responses to all three antigens were similar in asplenic patients and controls at 28 days following immunization. In contrast, asplenic patients had significantly lower IgM concentrations in response to Hib (P <.05) and to both pneumococcal serotypes 14 (P <.005 and 18C (P <.001). IgA anti-Hib antibody was also lower in the asplenic group, as was total anti-Hib antibody measured by RIA. These results document that IgG responses to polysaccharide vaccines are normal in asplenic patients. The impaired IgM responses of these patients may explain conflicting reports from studies that measured only total antibody-binding concentrations.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/314582</identifier><identifier>PMID: 9878041</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: University Chicago Press</publisher><subject>Adolescent ; Adult ; Antibodies ; Antibodies, Bacterial - biosynthesis ; Antibodies, Bacterial - immunology ; Antigens ; Bacterial Vaccines - immunology ; Bacteriology ; Biological and medical sciences ; Child ; Concise Communications ; Control groups ; Enzyme linked immunosorbent assay ; Female ; Fundamental and applied biological sciences. Psychology ; Geometric mean ; Haemophilus Vaccines - immunology ; Humans ; Immunization ; Immunoglobulin A - immunology ; Immunoglobulin G - immunology ; Immunoglobulin M - immunology ; Male ; Meningococcal Vaccines ; Microbiology ; Middle Aged ; Pneumococcal vaccine ; Polysaccharides ; Polysaccharides - immunology ; Spleen - immunology ; Splenectomy ; Vaccination ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><ispartof>The Journal of infectious diseases, 1999-02, Vol.179 (2), p.513-517</ispartof><rights>Copyright 1999 Infectious Diseases Society of America</rights><rights>1999 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Feb 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-9cdfbcdda3777cfc6208d709738a3948b3bb99f08b04ecb6fc68138a063023073</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30117297$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30117297$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1707245$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9878041$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Molrine, Deborah C.</creatorcontrib><creatorcontrib>Siber, George R.</creatorcontrib><creatorcontrib>Samra, Yecheskel</creatorcontrib><creatorcontrib>Shevy, Drora Samra</creatorcontrib><creatorcontrib>MacDonald, Kristin</creatorcontrib><creatorcontrib>Cieri, Rocco</creatorcontrib><creatorcontrib>Ambrosino, Donna M.</creatorcontrib><title>Normal IgG and Impaired IgM Responses to Polysaccharide Vaccines in Asplenic Patients</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><description>Asplenic patients are at increased risk for life-threatening infections with polysaccharide-encapsulated organisms, and reports of responses to polysaccharide vaccines have been conflicting. Thirty-six asplenic patients and 15 healthy controls were immunized with pneumococcal, Haemophilus influenzae type b (Hib), and meningococcal vaccines. Antibody concentrations to Hib and pneumococcal serotypes 14 and 18C were measured by ELISA. IgG antibody responses to all three antigens were similar in asplenic patients and controls at 28 days following immunization. In contrast, asplenic patients had significantly lower IgM concentrations in response to Hib (P <.05) and to both pneumococcal serotypes 14 (P <.005 and 18C (P <.001). IgA anti-Hib antibody was also lower in the asplenic group, as was total anti-Hib antibody measured by RIA. These results document that IgG responses to polysaccharide vaccines are normal in asplenic patients. The impaired IgM responses of these patients may explain conflicting reports from studies that measured only total antibody-binding concentrations.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antibodies</subject><subject>Antibodies, Bacterial - biosynthesis</subject><subject>Antibodies, Bacterial - immunology</subject><subject>Antigens</subject><subject>Bacterial Vaccines - immunology</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Concise Communications</subject><subject>Control groups</subject><subject>Enzyme linked immunosorbent assay</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Geometric mean</subject><subject>Haemophilus Vaccines - immunology</subject><subject>Humans</subject><subject>Immunization</subject><subject>Immunoglobulin A - immunology</subject><subject>Immunoglobulin G - immunology</subject><subject>Immunoglobulin M - immunology</subject><subject>Male</subject><subject>Meningococcal Vaccines</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Pneumococcal vaccine</subject><subject>Polysaccharides</subject><subject>Polysaccharides - immunology</subject><subject>Spleen - immunology</subject><subject>Splenectomy</subject><subject>Vaccination</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkF1rFDEUhoModa36D4Qg4t3oSTKTj8uy2HZLraW0UrwJmUymZp1JxmQW7L9vyi674NU58Dy8nPMi9J7AFwKSf2WkbiR9gRakYaLinLCXaAFAaUWkUq_Rm5zXAFAzLo7QkZJCQk0W6O4qptEMePVwhk3o8GqcjE-uLA_f8Y3LUwzZZTxHfB2Hx2ys_W2S7xz-WVYfCvIBn-RpcMFbfG1m78Kc36JXvRmye7ebx-ju9Nvt8ry6_HG2Wp5cVramdK6U7frWdp1hQgjbW05BdgKUYNIwVcuWta1SPcgWamdbXgxJCgPOgDIQ7Bh93uZOKf7duDzr0WfrhsEEFzdZc9UwKRso4sf_xHXcpFBu05QyBYrX6pBmU8w5uV5PyY8mPWoC-rlkvS25iB92aZt2dN1e27Va-KcdN9maoU8mWJ8PaQIErZtDzDrPMe0xA0IEVc_fVVvu8-z-7blJfzQXTDT6_P6Xvr05vefLC6Wv2BM4-JnV</recordid><startdate>19990201</startdate><enddate>19990201</enddate><creator>Molrine, Deborah C.</creator><creator>Siber, George R.</creator><creator>Samra, Yecheskel</creator><creator>Shevy, Drora Samra</creator><creator>MacDonald, Kristin</creator><creator>Cieri, Rocco</creator><creator>Ambrosino, Donna M.</creator><general>University Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>19990201</creationdate><title>Normal IgG and Impaired IgM Responses to Polysaccharide Vaccines in Asplenic Patients</title><author>Molrine, Deborah C. ; Siber, George R. ; Samra, Yecheskel ; Shevy, Drora Samra ; MacDonald, Kristin ; Cieri, Rocco ; Ambrosino, Donna M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-9cdfbcdda3777cfc6208d709738a3948b3bb99f08b04ecb6fc68138a063023073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antibodies</topic><topic>Antibodies, Bacterial - biosynthesis</topic><topic>Antibodies, Bacterial - immunology</topic><topic>Antigens</topic><topic>Bacterial Vaccines - immunology</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Concise Communications</topic><topic>Control groups</topic><topic>Enzyme linked immunosorbent assay</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Geometric mean</topic><topic>Haemophilus Vaccines - immunology</topic><topic>Humans</topic><topic>Immunization</topic><topic>Immunoglobulin A - immunology</topic><topic>Immunoglobulin G - immunology</topic><topic>Immunoglobulin M - immunology</topic><topic>Male</topic><topic>Meningococcal Vaccines</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Pneumococcal vaccine</topic><topic>Polysaccharides</topic><topic>Polysaccharides - immunology</topic><topic>Spleen - immunology</topic><topic>Splenectomy</topic><topic>Vaccination</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Molrine, Deborah C.</creatorcontrib><creatorcontrib>Siber, George R.</creatorcontrib><creatorcontrib>Samra, Yecheskel</creatorcontrib><creatorcontrib>Shevy, Drora Samra</creatorcontrib><creatorcontrib>MacDonald, Kristin</creatorcontrib><creatorcontrib>Cieri, Rocco</creatorcontrib><creatorcontrib>Ambrosino, Donna M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Molrine, Deborah C.</au><au>Siber, George R.</au><au>Samra, Yecheskel</au><au>Shevy, Drora Samra</au><au>MacDonald, Kristin</au><au>Cieri, Rocco</au><au>Ambrosino, Donna M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Normal IgG and Impaired IgM Responses to Polysaccharide Vaccines in Asplenic Patients</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>The Journal of Infectious Diseases</addtitle><date>1999-02-01</date><risdate>1999</risdate><volume>179</volume><issue>2</issue><spage>513</spage><epage>517</epage><pages>513-517</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Asplenic patients are at increased risk for life-threatening infections with polysaccharide-encapsulated organisms, and reports of responses to polysaccharide vaccines have been conflicting. Thirty-six asplenic patients and 15 healthy controls were immunized with pneumococcal, Haemophilus influenzae type b (Hib), and meningococcal vaccines. Antibody concentrations to Hib and pneumococcal serotypes 14 and 18C were measured by ELISA. IgG antibody responses to all three antigens were similar in asplenic patients and controls at 28 days following immunization. In contrast, asplenic patients had significantly lower IgM concentrations in response to Hib (P <.05) and to both pneumococcal serotypes 14 (P <.005 and 18C (P <.001). IgA anti-Hib antibody was also lower in the asplenic group, as was total anti-Hib antibody measured by RIA. These results document that IgG responses to polysaccharide vaccines are normal in asplenic patients. The impaired IgM responses of these patients may explain conflicting reports from studies that measured only total antibody-binding concentrations.</abstract><cop>Chicago, IL</cop><pub>University Chicago Press</pub><pmid>9878041</pmid><doi>10.1086/314582</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of infectious diseases, 1999-02, Vol.179 (2), p.513-517 |
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| subjects | Adolescent Adult Antibodies Antibodies, Bacterial - biosynthesis Antibodies, Bacterial - immunology Antigens Bacterial Vaccines - immunology Bacteriology Biological and medical sciences Child Concise Communications Control groups Enzyme linked immunosorbent assay Female Fundamental and applied biological sciences. Psychology Geometric mean Haemophilus Vaccines - immunology Humans Immunization Immunoglobulin A - immunology Immunoglobulin G - immunology Immunoglobulin M - immunology Male Meningococcal Vaccines Microbiology Middle Aged Pneumococcal vaccine Polysaccharides Polysaccharides - immunology Spleen - immunology Splenectomy Vaccination Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies |
| title | Normal IgG and Impaired IgM Responses to Polysaccharide Vaccines in Asplenic Patients |
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