Preparation of Highly Photosensitizing Liposomes with Fullerene-Doped Lipid Bilayer Using Dispersion-Controllable Molecular Exchange Reactions
Fullerene-containing liposomes with high photosensitization ability were prepared. Disaggregated fullerenes were efficiently injected into the bilayer of liposomes by a phototriggered molecular exchange reaction. These liposomes showed far higher photoreactivity than liposomes thermally produced by...
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| Veröffentlicht in: | Organic letters 2008-09, Vol.10 (18), p.4077-4080 |
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| container_title | Organic letters |
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| creator | Ikeda, Atsushi Sue, Tatsuya Akiyama, Motofusa Fujioka, Katsuyoshi Shigematsu, Tamami Doi, Yuki Kikuchi, Jun-ichi Konishi, Toshifumi Nakajima, Riichiro |
| description | Fullerene-containing liposomes with high photosensitization ability were prepared. Disaggregated fullerenes were efficiently injected into the bilayer of liposomes by a phototriggered molecular exchange reaction. These liposomes showed far higher photoreactivity than liposomes thermally produced by heating and microwave irradiation. This result indicates that control of self-aggregation of fullerene leads to a high quantum yield for the photoreaction because of the suppression of self-quenching of photoexcited fullerenes. |
| doi_str_mv | 10.1021/ol8015918 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1523-7060 |
| ispartof | Organic letters, 2008-09, Vol.10 (18), p.4077-4080 |
| issn | 1523-7060 1523-7052 |
| language | eng |
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| source | MEDLINE; ACS Publications |
| subjects | Cyclodextrins - chemistry Drug Carriers - chemical synthesis Drug Carriers - chemistry Fullerenes - chemistry Lipid Bilayers - chemistry Liposomes - chemical synthesis Liposomes - chemistry Photosensitizing Agents - chemical synthesis Photosensitizing Agents - chemistry |
| title | Preparation of Highly Photosensitizing Liposomes with Fullerene-Doped Lipid Bilayer Using Dispersion-Controllable Molecular Exchange Reactions |
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