Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas

Selective inhibitors of the glycine transporter 1 (GlyT1) have been implicated in central nervous system disorders related to hypoglutamatergic function such as schizophrenia. The selective GlyT1 inhibitors ALX5407 (NFPS) and LY2365109 {[2-(4-benzo[1,3]dioxol-5-yl-2- tert-butylphenoxy)ethyl]-methyla...

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Veröffentlicht in:	Neuropharmacology 2008-10, Vol.55 (5), p.743-754
Hauptverfasser:	Perry, Kenneth W., Falcone, Julie F., Fell, Matthew J., Ryder, John W., Yu, Hong, Love, Patrick L., Katner, Jason, Gordon, Kimberly D., Wade, Mark R., Man, Teresa, Nomikos, George G., Phebus, Lee A., Cauvin, Annick J., Johnson, Kirk W., Jones, Carrie K., Hoffmann, Beth J., Sandusky, George E., Walter, Magnus W., Porter, Warren J., Yang, Lijuan, Merchant, Kalpana M., Shannon, Harlan E., Svensson, Kjell A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal - drug effects Brain Chemistry - drug effects Cell Line, Tumor Cerebral Cortex - drug effects cGMP Corpus Striatum - drug effects Cyclic GMP - metabolism Dioxoles - pharmacology Dose-Response Relationship, Drug Excitatory Amino Acid Antagonists - pharmacology Glycine Glycine - metabolism Glycine Plasma Membrane Transport Proteins - antagonists & inhibitors Humans Immuno-staining Male Mice Microdialysis Microdialysis - methods Motor Activity - drug effects Neuroblastoma Neurotransmitter Agents - metabolism NMDA Quinolones - pharmacology Rats Rats, Sprague-Dawley Rats, Wistar Respiration Sarcosine - analogs & derivatives Sarcosine - pharmacology Time Factors
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