BCAR3 regulates EGF-induced DNA synthesis in normal human breast MCF-12A cells

BCAR3 (breast cancer anti-estrogen resistance 3) is a signal transducer containing an SH2 domain, a proline/serine-rich domain and a GDP-exchange factor homologous domain, whose role in signaling pathways is currently unclear. Furthermore, BCAR3 is implicated in anti-estrogen resistance of breast ca...

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Veröffentlicht in:	Biochemical and biophysical research communications 2008-10, Vol.375 (3), p.430-434
Hauptverfasser:	Oh, Myung-Ju, van Agthoven, Ton, Choi, Ji-Eun, Jeong, Yeon-Ji, Chung, Young-Hwa, Kim, Cheol-Min, Jhun, Byung H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - immunology Adaptor Proteins, Signal Transducing - metabolism Antibodies - immunology BCAR3 Breast - cytology Breast - drug effects Breast - metabolism Cas Cell Cycle Cell Line DNA - biosynthesis DNA - drug effects DNA synthesis EGF Epidermal Growth Factor - metabolism Epidermal Growth Factor - pharmacology Humans IGF-1 Insulin Microinjection Microinjections Mitosis Receptor, Epidermal Growth Factor - metabolism RNA, Small Interfering - genetics SH2 domain src Homology Domains - genetics
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