Small Molecule Selectin Inhibitor in Global Cerebral Ischemia and Controlled Hemorrhagic Shock

BACKGROUND:The clinical and experimental management of stroke has not reached the therapeutic success seen in other medical conditions associated with ischemia/reperfusion. In this work, we investigated the effect of a small molecule selectin inhibitor TBC-1269, in animals subjected to global cerebr...

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Veröffentlicht in:	The Journal of trauma, injury, infection, and critical care injury, infection, and critical care, 2008-09, Vol.65 (3), p.678-684
Hauptverfasser:	Anaya-Prado, Roberto, Pérez-Gomez, Nahum, Toledo-Pereyra, Luis H., Walsh, John, Jordan, Jackie, Ward, Peter A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Biphenyl Compounds - therapeutic use Brain Ischemia - drug therapy Brain Ischemia - enzymology Brain Ischemia - pathology Cell Adhesion Molecules - antagonists & inhibitors Disease Models, Animal Diseases of the osteoarticular system Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care Intensive care medicine Male Mannose - analogs & derivatives Mannosides - therapeutic use Medical sciences Neurology Neutrophil Infiltration Peroxidase - metabolism Rats Rats, Sprague-Dawley Shock, Hemorrhagic - drug therapy Shock, Hemorrhagic - enzymology Shock, Hemorrhagic - pathology Vascular diseases and vascular malformations of the nervous system
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