I.V. acetaminophen pharmacokinetics in neonates after multiple doses

Pharmacokinetics of an i.v. prodrug of acetaminophen (propacetamol) in neonates after repeat dosing are reported, with scant data for i.v. acetaminophen formulation. Neonates from an intensive care unit received 6-hourly prn i.v. acetaminophen dosed according to postmenstrual age (PMA): 28–32 weeks,...

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Veröffentlicht in:	British journal of anaesthesia : BJA 2008-10, Vol.101 (4), p.523-530
Hauptverfasser:	Palmer, G.M., Atkins, M., Anderson, B.J., Smith, K.R., Culnane, T.J., McNally, C.M., Perkins, E.J., Chalkiadis, G.A., Hunt, R.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	acetaminophen Acetaminophen - administration & dosage Acetaminophen - blood Acetaminophen - therapeutic use analgesic techniques analgesic techniques, i.v analgesics non-opioid analgesics non-opioid, acetaminophen Analgesics, Non-Narcotic - administration & dosage Analgesics, Non-Narcotic - blood Analgesics, Non-Narcotic - therapeutic use Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Body Weight Female Gestational Age Humans Hyperbilirubinemia, Neonatal - blood i.v Infant, Newborn Infusions, Intravenous Male Medical sciences Metabolic Clearance Rate Models, Chemical Pain, Postoperative - drug therapy pharmacokinetics pharmacokinetics, models
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