Long-Term Effect of Growth Hormone (GH) Treatment on Body Composition in Children with GH Deficiency

Objective: It is important for GH-deficient children to treat abnormal body composition associated with a metabolic consequence, not only short stature. In this study we evaluated long-term effects of GH therapy on body composition in GH-deficient boys and girls. Subjects and Methods: Fortynine subj...

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Veröffentlicht in:Endocrine Journal 1999, Vol.46(Suppl), pp.S35-S38
Hauptverfasser: KUROMARU, RYUICHI, KOHNO, HITOSHI, UEYAMA, NAMI, HASSAN, HASSAN MOHAMED SALAMA, HONDA, SUNAO, HARA, TOSHIRO
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container_end_page S38
container_issue Suppl
container_start_page S35
container_title Endocrine Journal
container_volume 46
creator KUROMARU, RYUICHI
KOHNO, HITOSHI
UEYAMA, NAMI
HASSAN, HASSAN MOHAMED SALAMA
HONDA, SUNAO
HARA, TOSHIRO
description Objective: It is important for GH-deficient children to treat abnormal body composition associated with a metabolic consequence, not only short stature. In this study we evaluated long-term effects of GH therapy on body composition in GH-deficient boys and girls. Subjects and Methods: Fortynine subjects with GH deficiency, 35 boys and 14 girls, 6 to 14 years of age, were studied. All the subjects were treated for three years with recombinant human GH at a weekly dosage of 0.5IU/kg by subcutaneous daily injection. Body composition was measured by bioelectrical impedance analysis (BIA 101), Spectrum II 287, RJL Systems, Detroit, Mich. Results: Body fat (%) decreased significantly during the first three months of GH treatment. These values were maintained low thereafter in boys, in contrast to those which continued to tend upward in girls from the second year of the treatment. Lean body mass (kg) increased significantly with increasing extracellular water (kg) and body cell mass (kg) in both sexes during GH treatment. Conclusion: Our data demonstrate that GH can reduce body fat mass in GH-deficient boys and girls. The gender difference in changes in body fat with age during the course of this study is compatible with that observed in normal children. The rapid increase in extracellular water and the gradual increase in body cell mass both contributed to the steady increase in LBM during GH treatment.
doi_str_mv 10.1507/endocrj.46.Suppl_S35
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source MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals
subjects Adipose Tissue - drug effects
Adipose Tissue - metabolism
Adolescent
Body cell mass
Body composition
Body Composition - drug effects
Body Composition - physiology
Body Height - drug effects
Body Height - physiology
Child
Electric Impedance
Extracellular water
Female
GH deficiency
Growth Disorders - drug therapy
Growth Disorders - metabolism
Human Growth Hormone - deficiency
Human Growth Hormone - therapeutic use
Humans
Longitudinal Studies
Male
Recombinant Proteins
title Long-Term Effect of Growth Hormone (GH) Treatment on Body Composition in Children with GH Deficiency
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