Allelic methylation bias of the RARB2 tumor suppressor gene promoter in cancer

Retinoic acid receptor B2 (RARB2) is frequently inactivated in cancer. Methylation in the 5′‐untranslated region and first exon is known to play a role; however, few studies have analyzed the detailed methylation pattern of the promoter region. We show that hypo‐ and hypermethylated alleles coexist...

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Veröffentlicht in:	Genes chromosomes & cancer 2008-11, Vol.47 (11), p.978-993
Hauptverfasser:	Pappas, Jane J., Toulouse, André, Hébert, Josée, Fetni, Raouf, Bradley, W. E. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Base Sequence Cell Line, Tumor CpG Islands DNA Methylation Genes, Tumor Suppressor Humans In Situ Hybridization, Fluorescence Molecular Sequence Data Neoplasms - genetics Neoplasms - metabolism Promoter Regions, Genetic Receptors, Retinoic Acid - genetics Receptors, Retinoic Acid - metabolism RNA, Messenger - metabolism
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