Spatial Regulation of BMP Signaling by Patterned Receptor Expression
Local delivery of TGF-β/BMP ligands is commonly used as a tissue engineering strategy for the spatial regulation of cell growth and differentiation. While the location and the dose of ligand are the only parameters that influence the spatial distribution and biological effects of the ligand in vitro...
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| Veröffentlicht in: | Tissue engineering. Part A 2008-09, Vol.14 (9), p.1469-1477 |
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| creator | Lembong, Jessica Yakoby, Nir Shvartsman, Stanislav Y. |
| description | Local delivery of TGF-β/BMP ligands is commonly used as a tissue engineering strategy for the spatial regulation of cell growth and differentiation. While the location and the dose of ligand are the only parameters that influence the spatial distribution and biological effects of the ligand
in vitro
,
in vivo
genetic studies of development reveal that spatial control of TGF-β/BMP signaling can be accomplished at multiple levels, from ligand release to signal interpretation. Here we focus on spatial control of BMP signaling by patterned receptor expression. Motivated by our recent experimental analysis of the two-dimensional BMP signaling patterns in the developing
Drosophila
egg, we formulate one- and two-dimensional models of ligand diffusion and internalization in the presence of patterned receptor expression. Our analysis of these models shows that they can capture the quantitative features of the experimentally observed pattern of phosphorylated SMAD in
Drosophila
oogenesis and shows that patterned receptor expression provides versatile control of BMP signaling in developing tissues. Quantitative understanding of the mechanisms of spatiotemporal control of signaling pathways in development is essential for successful harnessing of these pathways in tissue engineering. |
| doi_str_mv | 10.1089/ten.tea.2008.0098 |
| format | Article |
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in vitro
,
in vivo
genetic studies of development reveal that spatial control of TGF-β/BMP signaling can be accomplished at multiple levels, from ligand release to signal interpretation. Here we focus on spatial control of BMP signaling by patterned receptor expression. Motivated by our recent experimental analysis of the two-dimensional BMP signaling patterns in the developing
Drosophila
egg, we formulate one- and two-dimensional models of ligand diffusion and internalization in the presence of patterned receptor expression. Our analysis of these models shows that they can capture the quantitative features of the experimentally observed pattern of phosphorylated SMAD in
Drosophila
oogenesis and shows that patterned receptor expression provides versatile control of BMP signaling in developing tissues. Quantitative understanding of the mechanisms of spatiotemporal control of signaling pathways in development is essential for successful harnessing of these pathways in tissue engineering.</description><identifier>ISSN: 1937-3341</identifier><identifier>EISSN: 1937-335X</identifier><identifier>DOI: 10.1089/ten.tea.2008.0098</identifier><identifier>PMID: 18707227</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Animals ; Bone morphogenetic proteins ; Bone Morphogenetic Proteins - genetics ; Bone Morphogenetic Proteins - metabolism ; Bone Morphogenetic Proteins - physiology ; Cell growth ; Computational Biology ; Developmental biology ; Drosophila ; Drosophila Proteins - genetics ; Drosophila Proteins - metabolism ; Drosophila Proteins - physiology ; Embryo, Nonmammalian - metabolism ; Fluorescent Antibody Technique ; Gene expression ; Gene Expression Regulation, Developmental ; Genetic aspects ; Genetics ; Health aspects ; In Situ Hybridization ; Methods ; Models, Biological ; Original Papers ; Phosphorylation ; Signal transduction ; Signal Transduction - genetics ; Signal Transduction - physiology ; Smad Proteins - genetics ; Smad Proteins - metabolism ; Smad Proteins - physiology ; Tissue engineering ; Transforming Growth Factor beta - genetics ; Transforming Growth Factor beta - metabolism ; Transforming Growth Factor beta - physiology</subject><ispartof>Tissue engineering. Part A, 2008-09, Vol.14 (9), p.1469-1477</ispartof><rights>2008, Mary Ann Liebert, Inc.</rights><rights>COPYRIGHT 2008 Mary Ann Liebert, Inc.</rights><rights>(©) Copyright 2008, Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-f38dff693a49ca6f0165be56ae53bd127fdf2453508f5d608015e665b3f611e33</citedby><cites>FETCH-LOGICAL-c472t-f38dff693a49ca6f0165be56ae53bd127fdf2453508f5d608015e665b3f611e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.liebertpub.com/doi/epdf/10.1089/ten.tea.2008.0098$$EPDF$$P50$$Gmaryannliebert$$H</linktopdf><linktohtml>$$Uhttps://www.liebertpub.com/doi/full/10.1089/ten.tea.2008.0098$$EHTML$$P50$$Gmaryannliebert$$H</linktohtml><link.rule.ids>314,776,780,3029,21704,27903,27904,55269,55281</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18707227$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lembong, Jessica</creatorcontrib><creatorcontrib>Yakoby, Nir</creatorcontrib><creatorcontrib>Shvartsman, Stanislav Y.</creatorcontrib><title>Spatial Regulation of BMP Signaling by Patterned Receptor Expression</title><title>Tissue engineering. Part A</title><addtitle>Tissue Eng Part A</addtitle><description>Local delivery of TGF-β/BMP ligands is commonly used as a tissue engineering strategy for the spatial regulation of cell growth and differentiation. While the location and the dose of ligand are the only parameters that influence the spatial distribution and biological effects of the ligand
in vitro
,
in vivo
genetic studies of development reveal that spatial control of TGF-β/BMP signaling can be accomplished at multiple levels, from ligand release to signal interpretation. Here we focus on spatial control of BMP signaling by patterned receptor expression. Motivated by our recent experimental analysis of the two-dimensional BMP signaling patterns in the developing
Drosophila
egg, we formulate one- and two-dimensional models of ligand diffusion and internalization in the presence of patterned receptor expression. Our analysis of these models shows that they can capture the quantitative features of the experimentally observed pattern of phosphorylated SMAD in
Drosophila
oogenesis and shows that patterned receptor expression provides versatile control of BMP signaling in developing tissues. Quantitative understanding of the mechanisms of spatiotemporal control of signaling pathways in development is essential for successful harnessing of these pathways in tissue engineering.</description><subject>Animals</subject><subject>Bone morphogenetic proteins</subject><subject>Bone Morphogenetic Proteins - genetics</subject><subject>Bone Morphogenetic Proteins - metabolism</subject><subject>Bone Morphogenetic Proteins - physiology</subject><subject>Cell growth</subject><subject>Computational Biology</subject><subject>Developmental biology</subject><subject>Drosophila</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - metabolism</subject><subject>Drosophila Proteins - physiology</subject><subject>Embryo, Nonmammalian - metabolism</subject><subject>Fluorescent Antibody Technique</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genetic aspects</subject><subject>Genetics</subject><subject>Health aspects</subject><subject>In Situ Hybridization</subject><subject>Methods</subject><subject>Models, Biological</subject><subject>Original Papers</subject><subject>Phosphorylation</subject><subject>Signal transduction</subject><subject>Signal Transduction - genetics</subject><subject>Signal Transduction - physiology</subject><subject>Smad Proteins - genetics</subject><subject>Smad Proteins - metabolism</subject><subject>Smad Proteins - physiology</subject><subject>Tissue engineering</subject><subject>Transforming Growth Factor beta - genetics</subject><subject>Transforming Growth Factor beta - metabolism</subject><subject>Transforming Growth Factor beta - physiology</subject><issn>1937-3341</issn><issn>1937-335X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkVtLHTEUhYO0qLX-gL6UoQXfzpjL5DKP1toLWJRawbeQmdk5ROYkY5KB-u_NcA6VlkJLCNlsvrXY2QuhNwTXBKv2NIOvM5iaYqxqjFu1hw5Jy-SKMX734lfdkAP0KqV7jAUWUu6jA6IklpTKQ_TxZjLZmbH6Dut5LGXwVbDVh2_X1Y1bezM6v666x-ra5AzRw1DAHqYcYnXxc4qQUlG8Ri-tGRMc794jdPvp4sf5l9Xl1eev52eXq76RNK8sU4O1omWmaXsjLCaCd8CFAc66gVBpB0sbzjhWlg8CK0w4iMIwKwgBxo7QydZ3iuFhhpT1xqUextF4CHPSouVUMf5vsCwMKylUAd_9Ad6HOZZvLwyRVDZMFuj9FlqbEbTzNuRo-sVRn5VNijIzJYWq_0KVM8DG9cGDdaX_m4BsBX0MKUWweopuY-KjJlgv-eqSb7lmGVfpJd-iebubd-42MDwrdoEWQG6BpW28Hx10EPN_WD8BonKx_Q</recordid><startdate>20080901</startdate><enddate>20080901</enddate><creator>Lembong, Jessica</creator><creator>Yakoby, Nir</creator><creator>Shvartsman, Stanislav Y.</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7QO</scope><scope>7SS</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20080901</creationdate><title>Spatial Regulation of BMP Signaling by Patterned Receptor Expression</title><author>Lembong, Jessica ; Yakoby, Nir ; Shvartsman, Stanislav Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-f38dff693a49ca6f0165be56ae53bd127fdf2453508f5d608015e665b3f611e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Bone morphogenetic proteins</topic><topic>Bone Morphogenetic Proteins - genetics</topic><topic>Bone Morphogenetic Proteins - metabolism</topic><topic>Bone Morphogenetic Proteins - physiology</topic><topic>Cell growth</topic><topic>Computational Biology</topic><topic>Developmental biology</topic><topic>Drosophila</topic><topic>Drosophila Proteins - genetics</topic><topic>Drosophila Proteins - metabolism</topic><topic>Drosophila Proteins - physiology</topic><topic>Embryo, Nonmammalian - metabolism</topic><topic>Fluorescent Antibody Technique</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genetic aspects</topic><topic>Genetics</topic><topic>Health aspects</topic><topic>In Situ Hybridization</topic><topic>Methods</topic><topic>Models, Biological</topic><topic>Original Papers</topic><topic>Phosphorylation</topic><topic>Signal transduction</topic><topic>Signal Transduction - genetics</topic><topic>Signal Transduction - physiology</topic><topic>Smad Proteins - genetics</topic><topic>Smad Proteins - metabolism</topic><topic>Smad Proteins - physiology</topic><topic>Tissue engineering</topic><topic>Transforming Growth Factor beta - genetics</topic><topic>Transforming Growth Factor beta - metabolism</topic><topic>Transforming Growth Factor beta - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lembong, Jessica</creatorcontrib><creatorcontrib>Yakoby, Nir</creatorcontrib><creatorcontrib>Shvartsman, Stanislav Y.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Biotechnology Research Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Tissue engineering. Part A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lembong, Jessica</au><au>Yakoby, Nir</au><au>Shvartsman, Stanislav Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spatial Regulation of BMP Signaling by Patterned Receptor Expression</atitle><jtitle>Tissue engineering. Part A</jtitle><addtitle>Tissue Eng Part A</addtitle><date>2008-09-01</date><risdate>2008</risdate><volume>14</volume><issue>9</issue><spage>1469</spage><epage>1477</epage><pages>1469-1477</pages><issn>1937-3341</issn><eissn>1937-335X</eissn><abstract>Local delivery of TGF-β/BMP ligands is commonly used as a tissue engineering strategy for the spatial regulation of cell growth and differentiation. While the location and the dose of ligand are the only parameters that influence the spatial distribution and biological effects of the ligand
in vitro
,
in vivo
genetic studies of development reveal that spatial control of TGF-β/BMP signaling can be accomplished at multiple levels, from ligand release to signal interpretation. Here we focus on spatial control of BMP signaling by patterned receptor expression. Motivated by our recent experimental analysis of the two-dimensional BMP signaling patterns in the developing
Drosophila
egg, we formulate one- and two-dimensional models of ligand diffusion and internalization in the presence of patterned receptor expression. Our analysis of these models shows that they can capture the quantitative features of the experimentally observed pattern of phosphorylated SMAD in
Drosophila
oogenesis and shows that patterned receptor expression provides versatile control of BMP signaling in developing tissues. Quantitative understanding of the mechanisms of spatiotemporal control of signaling pathways in development is essential for successful harnessing of these pathways in tissue engineering.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>18707227</pmid><doi>10.1089/ten.tea.2008.0098</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Tissue engineering. Part A, 2008-09, Vol.14 (9), p.1469-1477 |
| issn | 1937-3341 1937-335X |
| language | eng |
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| source | Mary Ann Liebert Online Subscription; MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Bone morphogenetic proteins Bone Morphogenetic Proteins - genetics Bone Morphogenetic Proteins - metabolism Bone Morphogenetic Proteins - physiology Cell growth Computational Biology Developmental biology Drosophila Drosophila Proteins - genetics Drosophila Proteins - metabolism Drosophila Proteins - physiology Embryo, Nonmammalian - metabolism Fluorescent Antibody Technique Gene expression Gene Expression Regulation, Developmental Genetic aspects Genetics Health aspects In Situ Hybridization Methods Models, Biological Original Papers Phosphorylation Signal transduction Signal Transduction - genetics Signal Transduction - physiology Smad Proteins - genetics Smad Proteins - metabolism Smad Proteins - physiology Tissue engineering Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Transforming Growth Factor beta - physiology |
| title | Spatial Regulation of BMP Signaling by Patterned Receptor Expression |
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