Host responses in the bursa of Fabricius of chickens infected with virulent Marek's disease virus
Abstract The bursa of Fabricius serves as an important tissue in the process of Marek's disease virus (MDV) pathogenesis, since B cells of the bursa harbor the cytolytic phase of MDV replication cycle. In the present study, host responses associated with MDV infection in the bursa of Fabricius...
Gespeichert in:
| Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 2008-09, Vol.379 (2), p.256-265 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 265 |
|---|---|
| container_issue | 2 |
| container_start_page | 256 |
| container_title | Virology (New York, N.Y.) |
| container_volume | 379 |
| creator | Abdul-Careem, M.F Hunter, B.D Lee, L.F Fairbrother, J.H Haghighi, H.R Read, L Parvizi, P Heidari, M Sharif, S |
| description | Abstract The bursa of Fabricius serves as an important tissue in the process of Marek's disease virus (MDV) pathogenesis, since B cells of the bursa harbor the cytolytic phase of MDV replication cycle. In the present study, host responses associated with MDV infection in the bursa of Fabricius of chickens were investigated. The expression of MDV phosphoprotein (pp)38 antigen, MDV glycoprotein (gB) and MDV viral interleukin (vIL)-8 transcripts was at the highest at 4 days post-infection (d.p.i.) and then showed a declining trend. On the contrary, the expression of meq (MDV EcoRI Q) gene as well as the viral genome load increased gradually until day 14 post-infection. The changes in viral parameters were associated with significantly higher infiltration of macrophages and T cell subsets, particularly CD4+ T cells into the bursa of Fabricius. Of the genes examined, the expression of interferon (IFN)-α, IFN-γ genes and inducible nitric oxide synthase (iNOS) was significantly up-regulated in response to MDV infection in the bursa of Fabricius. The results suggest a role for these cells and cytokines in MDV-induced responses in the bursa of Fabricius. |
| doi_str_mv | 10.1016/j.virol.2008.06.027 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69525406</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0042682208004182</els_id><sourcerecordid>19486457</sourcerecordid><originalsourceid>FETCH-LOGICAL-c443t-72f65277927f0a536842150d7a8d9017cbdf049afdc2f2e050a38032f1ee1a1e3</originalsourceid><addsrcrecordid>eNqFkkFv1DAQhS0EokvhFyAhn-gpYew4dnIACVWUIrXqAThbXmes9W42WTxJUf99ne5KSFx6skf-3oz13jD2XkApQOhP2_I-prEvJUBTgi5BmhdsJaDVBVRKvGQrACUL3Uh5xt4QbSHXxsBrdiYabWpVmRVz1yNNPCEdxoGQeBz4tEG-nhM5PgZ-5dYp-jjTUvhN9DscFiqgn7Djf-O04fkbc4_DxG9dwt0F8S4SOsKnB3rLXgXXE747nefs99W3X5fXxc3d9x-XX28Kr1Q1FUYGXUtjWmkCuLrSjZKihs64pmtBGL_uAqjWhc7LIBFqcFUDlQwCUTiB1Tn7eOx7SOOfGWmy-0ge-94NOM5kdVvLWoF-FhStarSqTQarI-jTSJQw2EOKe5cerAC7RGC39ikCu0RgQdscQVZ9OLWf13vs_mlOnmfg8xHA7MZ9xGTJRxw8djFlV203xmcGfPlP7_s4RO_6HT4gbcc5DdloKyxJC_bnsgXLEkCTb6KR1SPenq2b</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19486457</pqid></control><display><type>article</type><title>Host responses in the bursa of Fabricius of chickens infected with virulent Marek's disease virus</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Abdul-Careem, M.F ; Hunter, B.D ; Lee, L.F ; Fairbrother, J.H ; Haghighi, H.R ; Read, L ; Parvizi, P ; Heidari, M ; Sharif, S</creator><creatorcontrib>Abdul-Careem, M.F ; Hunter, B.D ; Lee, L.F ; Fairbrother, J.H ; Haghighi, H.R ; Read, L ; Parvizi, P ; Heidari, M ; Sharif, S</creatorcontrib><description>Abstract The bursa of Fabricius serves as an important tissue in the process of Marek's disease virus (MDV) pathogenesis, since B cells of the bursa harbor the cytolytic phase of MDV replication cycle. In the present study, host responses associated with MDV infection in the bursa of Fabricius of chickens were investigated. The expression of MDV phosphoprotein (pp)38 antigen, MDV glycoprotein (gB) and MDV viral interleukin (vIL)-8 transcripts was at the highest at 4 days post-infection (d.p.i.) and then showed a declining trend. On the contrary, the expression of meq (MDV EcoRI Q) gene as well as the viral genome load increased gradually until day 14 post-infection. The changes in viral parameters were associated with significantly higher infiltration of macrophages and T cell subsets, particularly CD4+ T cells into the bursa of Fabricius. Of the genes examined, the expression of interferon (IFN)-α, IFN-γ genes and inducible nitric oxide synthase (iNOS) was significantly up-regulated in response to MDV infection in the bursa of Fabricius. The results suggest a role for these cells and cytokines in MDV-induced responses in the bursa of Fabricius.</description><identifier>ISSN: 0042-6822</identifier><identifier>EISSN: 1096-0341</identifier><identifier>DOI: 10.1016/j.virol.2008.06.027</identifier><identifier>PMID: 18675437</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Animals, Newborn ; Antigens, Viral - metabolism ; Base Sequence ; Bursa of Fabricius ; Bursa of Fabricius - immunology ; Bursa of Fabricius - pathology ; Bursa of Fabricius - virology ; Chickens ; Cytokine ; Cytokines - genetics ; DNA Primers - genetics ; Gene Expression ; Host-Pathogen Interactions - genetics ; Host-Pathogen Interactions - immunology ; Infectious Disease ; Macrophages ; Macrophages - pathology ; Macrophages - virology ; Mardivirus - genetics ; Mardivirus - immunology ; Mardivirus - pathogenicity ; Mardivirus - physiology ; Marek Disease - genetics ; Marek Disease - immunology ; Marek Disease - pathology ; Marek Disease - virology ; Marek's disease herpesvirus ; Marek's disease virus ; Nitric Oxide Synthase Type II - genetics ; Phosphoproteins - metabolism ; Real-time PCR ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; T cells ; T-Lymphocyte Subsets - pathology ; T-Lymphocyte Subsets - virology ; Virulence ; Virus Replication</subject><ispartof>Virology (New York, N.Y.), 2008-09, Vol.379 (2), p.256-265</ispartof><rights>Elsevier Inc.</rights><rights>2008 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-72f65277927f0a536842150d7a8d9017cbdf049afdc2f2e050a38032f1ee1a1e3</citedby><cites>FETCH-LOGICAL-c443t-72f65277927f0a536842150d7a8d9017cbdf049afdc2f2e050a38032f1ee1a1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0042682208004182$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18675437$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abdul-Careem, M.F</creatorcontrib><creatorcontrib>Hunter, B.D</creatorcontrib><creatorcontrib>Lee, L.F</creatorcontrib><creatorcontrib>Fairbrother, J.H</creatorcontrib><creatorcontrib>Haghighi, H.R</creatorcontrib><creatorcontrib>Read, L</creatorcontrib><creatorcontrib>Parvizi, P</creatorcontrib><creatorcontrib>Heidari, M</creatorcontrib><creatorcontrib>Sharif, S</creatorcontrib><title>Host responses in the bursa of Fabricius of chickens infected with virulent Marek's disease virus</title><title>Virology (New York, N.Y.)</title><addtitle>Virology</addtitle><description>Abstract The bursa of Fabricius serves as an important tissue in the process of Marek's disease virus (MDV) pathogenesis, since B cells of the bursa harbor the cytolytic phase of MDV replication cycle. In the present study, host responses associated with MDV infection in the bursa of Fabricius of chickens were investigated. The expression of MDV phosphoprotein (pp)38 antigen, MDV glycoprotein (gB) and MDV viral interleukin (vIL)-8 transcripts was at the highest at 4 days post-infection (d.p.i.) and then showed a declining trend. On the contrary, the expression of meq (MDV EcoRI Q) gene as well as the viral genome load increased gradually until day 14 post-infection. The changes in viral parameters were associated with significantly higher infiltration of macrophages and T cell subsets, particularly CD4+ T cells into the bursa of Fabricius. Of the genes examined, the expression of interferon (IFN)-α, IFN-γ genes and inducible nitric oxide synthase (iNOS) was significantly up-regulated in response to MDV infection in the bursa of Fabricius. The results suggest a role for these cells and cytokines in MDV-induced responses in the bursa of Fabricius.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Antigens, Viral - metabolism</subject><subject>Base Sequence</subject><subject>Bursa of Fabricius</subject><subject>Bursa of Fabricius - immunology</subject><subject>Bursa of Fabricius - pathology</subject><subject>Bursa of Fabricius - virology</subject><subject>Chickens</subject><subject>Cytokine</subject><subject>Cytokines - genetics</subject><subject>DNA Primers - genetics</subject><subject>Gene Expression</subject><subject>Host-Pathogen Interactions - genetics</subject><subject>Host-Pathogen Interactions - immunology</subject><subject>Infectious Disease</subject><subject>Macrophages</subject><subject>Macrophages - pathology</subject><subject>Macrophages - virology</subject><subject>Mardivirus - genetics</subject><subject>Mardivirus - immunology</subject><subject>Mardivirus - pathogenicity</subject><subject>Mardivirus - physiology</subject><subject>Marek Disease - genetics</subject><subject>Marek Disease - immunology</subject><subject>Marek Disease - pathology</subject><subject>Marek Disease - virology</subject><subject>Marek's disease herpesvirus</subject><subject>Marek's disease virus</subject><subject>Nitric Oxide Synthase Type II - genetics</subject><subject>Phosphoproteins - metabolism</subject><subject>Real-time PCR</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>T cells</subject><subject>T-Lymphocyte Subsets - pathology</subject><subject>T-Lymphocyte Subsets - virology</subject><subject>Virulence</subject><subject>Virus Replication</subject><issn>0042-6822</issn><issn>1096-0341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkFv1DAQhS0EokvhFyAhn-gpYew4dnIACVWUIrXqAThbXmes9W42WTxJUf99ne5KSFx6skf-3oz13jD2XkApQOhP2_I-prEvJUBTgi5BmhdsJaDVBVRKvGQrACUL3Uh5xt4QbSHXxsBrdiYabWpVmRVz1yNNPCEdxoGQeBz4tEG-nhM5PgZ-5dYp-jjTUvhN9DscFiqgn7Djf-O04fkbc4_DxG9dwt0F8S4SOsKnB3rLXgXXE747nefs99W3X5fXxc3d9x-XX28Kr1Q1FUYGXUtjWmkCuLrSjZKihs64pmtBGL_uAqjWhc7LIBFqcFUDlQwCUTiB1Tn7eOx7SOOfGWmy-0ge-94NOM5kdVvLWoF-FhStarSqTQarI-jTSJQw2EOKe5cerAC7RGC39ikCu0RgQdscQVZ9OLWf13vs_mlOnmfg8xHA7MZ9xGTJRxw8djFlV203xmcGfPlP7_s4RO_6HT4gbcc5DdloKyxJC_bnsgXLEkCTb6KR1SPenq2b</recordid><startdate>20080930</startdate><enddate>20080930</enddate><creator>Abdul-Careem, M.F</creator><creator>Hunter, B.D</creator><creator>Lee, L.F</creator><creator>Fairbrother, J.H</creator><creator>Haghighi, H.R</creator><creator>Read, L</creator><creator>Parvizi, P</creator><creator>Heidari, M</creator><creator>Sharif, S</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20080930</creationdate><title>Host responses in the bursa of Fabricius of chickens infected with virulent Marek's disease virus</title><author>Abdul-Careem, M.F ; Hunter, B.D ; Lee, L.F ; Fairbrother, J.H ; Haghighi, H.R ; Read, L ; Parvizi, P ; Heidari, M ; Sharif, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-72f65277927f0a536842150d7a8d9017cbdf049afdc2f2e050a38032f1ee1a1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Antigens, Viral - metabolism</topic><topic>Base Sequence</topic><topic>Bursa of Fabricius</topic><topic>Bursa of Fabricius - immunology</topic><topic>Bursa of Fabricius - pathology</topic><topic>Bursa of Fabricius - virology</topic><topic>Chickens</topic><topic>Cytokine</topic><topic>Cytokines - genetics</topic><topic>DNA Primers - genetics</topic><topic>Gene Expression</topic><topic>Host-Pathogen Interactions - genetics</topic><topic>Host-Pathogen Interactions - immunology</topic><topic>Infectious Disease</topic><topic>Macrophages</topic><topic>Macrophages - pathology</topic><topic>Macrophages - virology</topic><topic>Mardivirus - genetics</topic><topic>Mardivirus - immunology</topic><topic>Mardivirus - pathogenicity</topic><topic>Mardivirus - physiology</topic><topic>Marek Disease - genetics</topic><topic>Marek Disease - immunology</topic><topic>Marek Disease - pathology</topic><topic>Marek Disease - virology</topic><topic>Marek's disease herpesvirus</topic><topic>Marek's disease virus</topic><topic>Nitric Oxide Synthase Type II - genetics</topic><topic>Phosphoproteins - metabolism</topic><topic>Real-time PCR</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>T cells</topic><topic>T-Lymphocyte Subsets - pathology</topic><topic>T-Lymphocyte Subsets - virology</topic><topic>Virulence</topic><topic>Virus Replication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdul-Careem, M.F</creatorcontrib><creatorcontrib>Hunter, B.D</creatorcontrib><creatorcontrib>Lee, L.F</creatorcontrib><creatorcontrib>Fairbrother, J.H</creatorcontrib><creatorcontrib>Haghighi, H.R</creatorcontrib><creatorcontrib>Read, L</creatorcontrib><creatorcontrib>Parvizi, P</creatorcontrib><creatorcontrib>Heidari, M</creatorcontrib><creatorcontrib>Sharif, S</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Virology (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdul-Careem, M.F</au><au>Hunter, B.D</au><au>Lee, L.F</au><au>Fairbrother, J.H</au><au>Haghighi, H.R</au><au>Read, L</au><au>Parvizi, P</au><au>Heidari, M</au><au>Sharif, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Host responses in the bursa of Fabricius of chickens infected with virulent Marek's disease virus</atitle><jtitle>Virology (New York, N.Y.)</jtitle><addtitle>Virology</addtitle><date>2008-09-30</date><risdate>2008</risdate><volume>379</volume><issue>2</issue><spage>256</spage><epage>265</epage><pages>256-265</pages><issn>0042-6822</issn><eissn>1096-0341</eissn><abstract>Abstract The bursa of Fabricius serves as an important tissue in the process of Marek's disease virus (MDV) pathogenesis, since B cells of the bursa harbor the cytolytic phase of MDV replication cycle. In the present study, host responses associated with MDV infection in the bursa of Fabricius of chickens were investigated. The expression of MDV phosphoprotein (pp)38 antigen, MDV glycoprotein (gB) and MDV viral interleukin (vIL)-8 transcripts was at the highest at 4 days post-infection (d.p.i.) and then showed a declining trend. On the contrary, the expression of meq (MDV EcoRI Q) gene as well as the viral genome load increased gradually until day 14 post-infection. The changes in viral parameters were associated with significantly higher infiltration of macrophages and T cell subsets, particularly CD4+ T cells into the bursa of Fabricius. Of the genes examined, the expression of interferon (IFN)-α, IFN-γ genes and inducible nitric oxide synthase (iNOS) was significantly up-regulated in response to MDV infection in the bursa of Fabricius. The results suggest a role for these cells and cytokines in MDV-induced responses in the bursa of Fabricius.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>18675437</pmid><doi>10.1016/j.virol.2008.06.027</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0042-6822 |
| ispartof | Virology (New York, N.Y.), 2008-09, Vol.379 (2), p.256-265 |
| issn | 0042-6822 1096-0341 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69525406 |
| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Animals, Newborn Antigens, Viral - metabolism Base Sequence Bursa of Fabricius Bursa of Fabricius - immunology Bursa of Fabricius - pathology Bursa of Fabricius - virology Chickens Cytokine Cytokines - genetics DNA Primers - genetics Gene Expression Host-Pathogen Interactions - genetics Host-Pathogen Interactions - immunology Infectious Disease Macrophages Macrophages - pathology Macrophages - virology Mardivirus - genetics Mardivirus - immunology Mardivirus - pathogenicity Mardivirus - physiology Marek Disease - genetics Marek Disease - immunology Marek Disease - pathology Marek Disease - virology Marek's disease herpesvirus Marek's disease virus Nitric Oxide Synthase Type II - genetics Phosphoproteins - metabolism Real-time PCR RNA, Messenger - genetics RNA, Messenger - metabolism T cells T-Lymphocyte Subsets - pathology T-Lymphocyte Subsets - virology Virulence Virus Replication |
| title | Host responses in the bursa of Fabricius of chickens infected with virulent Marek's disease virus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T08%3A39%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Host%20responses%20in%20the%20bursa%20of%20Fabricius%20of%20chickens%20infected%20with%20virulent%20Marek's%20disease%20virus&rft.jtitle=Virology%20(New%20York,%20N.Y.)&rft.au=Abdul-Careem,%20M.F&rft.date=2008-09-30&rft.volume=379&rft.issue=2&rft.spage=256&rft.epage=265&rft.pages=256-265&rft.issn=0042-6822&rft.eissn=1096-0341&rft_id=info:doi/10.1016/j.virol.2008.06.027&rft_dat=%3Cproquest_cross%3E19486457%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=19486457&rft_id=info:pmid/18675437&rft_els_id=1_s2_0_S0042682208004182&rfr_iscdi=true |