A Microscopic Study of the Deoxyhemoglobin-Catalyzed Generation of Nitric Oxide from Nitrite Anion

There is recent evidence suggesting that nitrite anion (NO2 −) represents the major intravascular NO storage molecule whose transduction to NO is facilitated by a reduction mechanism catalyzed by deoxygenated hemoglobin (deoxy-Hb). In this work, we provide a detailed microscopic study of deoxy-Hb ni...

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Veröffentlicht in:	Biochemistry (Easton) 2008-09, Vol.47 (37), p.9793-9802
Hauptverfasser:	Perissinotti, Laura L, Marti, Marcelo A, Doctorovich, Fabio, Luque, F. Javier, Estrin, Dario A
Format:	Artikel
Sprache:	eng
Schlagworte:	Anions - chemistry Anions - metabolism Binding Sites Catalysis Hemoglobins - chemistry Hemoglobins - metabolism Histidine - chemistry Histidine - metabolism Humans Ligands Models, Molecular Nitric Oxide - chemistry Nitric Oxide - metabolism Nitrite Reductases - chemistry Nitrite Reductases - metabolism Nitrites - chemistry Nitrites - metabolism Protein Conformation
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