In vitro and in vivo bioactivity of recombinant canine hepatocyte growth factor

Hepatocyte growth factor (HGF) is crucial for the development and regeneration of the liver and offers a possible new therapeutic strategy for the treatment of canine liver disease. In this study, the in vitro and in vivo bioactivity of recombinant canine HGF (rcHGF) produced with a baculoviral expr...

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Veröffentlicht in:	The veterinary journal (1997) 2008-10, Vol.178 (1), p.70-77
Hauptverfasser:	Arends, Brigitte, Spee, Bart, Hoffmann, Gaby, Jansen, Georgina E.G., Slump, Estel, Auriemma, Edoardo, IJzer, Jooske, Hemrika, Wieger, Romijn, Roland A., van der Heijden-Liefkens, Karin H.A., Sondermeijer, Paul J.A., van den Ingh, Ted S.G.A.M., Penning, Louis C., Rothuizen, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptosis bioactive properties biochemical pathways c-MET Cell Line dog diseases Dogs epithelial cells ERK1/2 excision Extracellular Signal-Regulated MAP Kinases - genetics Extracellular Signal-Regulated MAP Kinases - metabolism Female Gene Expression Regulation - drug effects Hepatectomy hepatocyte growth factor Hepatocyte Growth Factor - genetics Hepatocyte Growth Factor - metabolism Hepatocytes - drug effects HGF in vitro studies in vivo studies liver Liver - drug effects Liver - physiology liver diseases Liver regeneration Liver Regeneration - drug effects mitosis oncogenes Organ Size Partial hepatectomy PCNA phosphorylation physiological response PKB Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism Recombinant Proteins
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