Impact of Delta 32-CCR5 heterozygosity on HIV-1 genetic evolution and variability--a study of 4 individuals infected with closely related HIV-1 strains
A cluster of four patients acutely infected with a genetically almost identical virus, allowed us to investigate genetic variability and disease progression in early HIV-1 infection with minimal interference of virus specific factors. Two of the patients were heterozygous for the 32-bp deletion in t...
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| Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 2008-09, Vol.379 (2), p.213-222 |
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| container_title | Virology (New York, N.Y.) |
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| creator | Chalmet, Kristen Van Wanzeele, Filip Demecheleer, Els Dauwe, Kenny Pelgrom, Jolanda Van Der Gucht, Bea Vogelaers, Dirk Plum, Jean Stuyver, Lieven Vandekerckhove, Linos Verhofstede, Chris |
| description | A cluster of four patients acutely infected with a genetically almost identical virus, allowed us to investigate genetic variability and disease progression in early HIV-1 infection with minimal interference of virus specific factors. Two of the patients were heterozygous for the 32-bp deletion in the CCR5 coreceptor gene. Both showed a slower disease progression with lower viral load levels and a reduced rate of genetic evolution compared to the patients with normal CCR5 alleles. During 3 years of treatment-free follow-up, the mean pairwise genetic distance increased with 1.45% and 1.58% in the two patients with a 32-bp deletion allele compared to 3.05% and 3.57% in the two patients with normal CCR5 alleles. The observed relation between slower disease progression and a reduced evolutionary rate illustrates the influence of the virus replicative capacity, here most possibly hampered by the CCR5 heterozygosity in two of the four individuals, on the genetic evolution of the virus in the host. |
| doi_str_mv | 10.1016/j.virol.2008.06.036 |
| format | Article |
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The observed relation between slower disease progression and a reduced evolutionary rate illustrates the influence of the virus replicative capacity, here most possibly hampered by the CCR5 heterozygosity in two of the four individuals, on the genetic evolution of the virus in the host.</description><subject>Adult</subject><subject>Antiretroviral Therapy, Highly Active</subject><subject>Base Sequence</subject><subject>DNA Primers - genetics</subject><subject>Evolution, Molecular</subject><subject>Genes, env</subject><subject>Genetic Variation</subject><subject>Genotype</subject><subject>Heterozygote</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - genetics</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - genetics</subject><subject>HIV-1 - isolation & purification</subject><subject>Humans</subject><subject>Male</subject><subject>Molecular Sequence Data</subject><subject>Receptors, CCR5 - genetics</subject><subject>RNA, Viral - blood</subject><subject>RNA, Viral - genetics</subject><subject>Sequence Deletion</subject><issn>1096-0341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kF1LwzAUhoMgbk5_gSC58q41H23SXkr92GAgiHpb0vZ0y0ib2qST-kf8u3ZsXp3Dy3MeOC9CN5SElFBxvwv3urcmZIQkIREh4eIMzSlJRUB4RGfo0rkdISSSklygGU1Eyhhlc_S7ajpVemxr_AjGK8xZkGVvMd6Ch97-jBvrtB-xbfFy9RlQvIEWvC4x7K0ZvJ5y1VZ4r3qtCm0mNAgUdn6oxoMzwrqt9F5XgzJu2msoPVT4W_stLo11YEbcg1GH8Oh3vle6dVfovJ5O4Po0F-jj-ek9Wwbr15dV9rAOOspTH0RCUklknPBo-pOLqC5AxERASqlQaUpkwtIk4bKqFY2LulSqFEJJJgpgIqn4At0dvV1vvwZwPm-0K8EY1YIdXC7SmEWS8Qm8PYFD0UCVd71uVD_m_1XyPwcDdUA</recordid><startdate>20080930</startdate><enddate>20080930</enddate><creator>Chalmet, Kristen</creator><creator>Van Wanzeele, Filip</creator><creator>Demecheleer, Els</creator><creator>Dauwe, Kenny</creator><creator>Pelgrom, Jolanda</creator><creator>Van Der Gucht, Bea</creator><creator>Vogelaers, Dirk</creator><creator>Plum, Jean</creator><creator>Stuyver, Lieven</creator><creator>Vandekerckhove, Linos</creator><creator>Verhofstede, Chris</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20080930</creationdate><title>Impact of Delta 32-CCR5 heterozygosity on HIV-1 genetic evolution and variability--a study of 4 individuals infected with closely related HIV-1 strains</title><author>Chalmet, Kristen ; 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| ispartof | Virology (New York, N.Y.), 2008-09, Vol.379 (2), p.213-222 |
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| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Antiretroviral Therapy, Highly Active Base Sequence DNA Primers - genetics Evolution, Molecular Genes, env Genetic Variation Genotype Heterozygote HIV Infections - drug therapy HIV Infections - genetics HIV Infections - immunology HIV Infections - virology HIV-1 - genetics HIV-1 - isolation & purification Humans Male Molecular Sequence Data Receptors, CCR5 - genetics RNA, Viral - blood RNA, Viral - genetics Sequence Deletion |
| title | Impact of Delta 32-CCR5 heterozygosity on HIV-1 genetic evolution and variability--a study of 4 individuals infected with closely related HIV-1 strains |
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