Reduction of Age-Associated Pathology in Old Mice by Overexpression of Catalase in Mitochondria

We describe the effects of mitochondrially targeted catalase (MCAT) expression on end-of-life pathology in mice using detailed semiquantitative histopathological evaluation. We previously reported that the median and maximum life spans of MCAT mice were extended relative to those of wild-type litter...

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Veröffentlicht in:	The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2008-08, Vol.63 (8), p.813-822
Hauptverfasser:	Treuting, Piper M., Linford, Nancy J., Knoblaugh, Sue E., Emond, M. J., Morton, John F., Martin, George M., Rabinovitch, Peter S., Ladiges, Warren C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - pathology Aging - physiology Animals Catalase - metabolism Changes Comorbidity Disease Models, Animal Free radicals Genetic markers Longevity Mice Mice, Transgenic Mitochondria - metabolism Mitochondrial DNA Oxidative stress Oxidative Stress - physiology Pathology Reactive Oxygen Species Rodents Studies Temperature Tissues Transgenic animals
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