Inhibition of a Transcriptional Pause by RNA Anchoring to RNA Polymerase

We describe a mechanism by which nascent RNA inhibits transcriptional pausing. PutL RNA of bacteriophage HK022 suppresses transcription termination at downstream terminators and pausing within a nearby U-rich sequence. In vitro transcription and footprinting assays reveal that this pausing results f...

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Veröffentlicht in:	Molecular cell 2008-09, Vol.31 (5), p.683-694
Hauptverfasser:	Komissarova, Natalia, Velikodvorskaya, Tatiana, Sen, Ranjan, King, Rodney A., Banik-Maiti, Sarbani, Weisberg, Robert A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteriophage HK022 - genetics Bacteriophage HK022 - metabolism Base Sequence DNA DNA-Directed RNA Polymerases - genetics DNA-Directed RNA Polymerases - metabolism Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Gene Expression Regulation MICROBIO Models, Molecular Molecular Sequence Data Nucleic Acid Conformation Oligonucleotides, Antisense - genetics Oligonucleotides, Antisense - metabolism Protein Conformation RNA RNA - genetics RNA - metabolism Transcription, Genetic Transcriptional Elongation Factors - genetics Transcriptional Elongation Factors - metabolism Uridine - metabolism Viral Proteins - genetics Viral Proteins - metabolism
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