Differential effects of polymorphisms in the 5' flanking region of IL12RB2 on NK- and T-cell activity

Single nucleotide polymorphisms (SNPs) in the 5' flanking region of IL12RB2 are frequently detected in lepromatous leprosy patients, and may be possible immunogenetic factors that reduce transcriptional activity of the IL-12Rbeta2 gene in Jurkat T cells. This study determined the functional eff...

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Veröffentlicht in:	Journal of interferon & cytokine research 2008-09, Vol.28 (9), p.563-570
Hauptverfasser:	Ohyama, Hideki, Kato-Kogoe, Nahoko, Nishimura, Fusanori, Takeuchi-Hatanaka, Kazu, Matsushita, Sho, Yamanegi, Koji, Yamada, Naoko, Hata, Masaki, Nakasho, Keiji, Terada, Nobuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Flanking Region - genetics Genetic aspects Genotype Haplotypes - genetics Haplotypes - immunology Health aspects Humans Interferon-gamma - immunology Interleukin-12 Jurkat Cells Killer cells Killer Cells, Natural - immunology Leprosy, Lepromatous - genetics Leprosy, Lepromatous - immunology Polymorphism, Single Nucleotide Receptors, Interleukin-12 - genetics Receptors, Interleukin-12 - immunology RNA, Messenger - genetics Single nucleotide polymorphisms T cells T-Lymphocytes - immunology
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