Dominance of cytokine- over FasL-induced impairment of the mitochondrial transmembrane potential (ΔΨm) in the pancreatic β-cell line NIT-1

Mitochondria of pancreatic β-cells are potential targets of intrinsic and extrinsic apoptotic pathways in the autoimmune pathogenesis of type 1 diabetes. We aimed to investigate whether cytokine- and FasLigand (FasL)-induced apoptosis is associated with impaired mitochondrial transmembrane potential...

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Veröffentlicht in:	Diabetes & vascular disease research 2008-09, Vol.5 (3), p.198-204
Hauptverfasser:	Augstein, Petra, Heinke, Peter, Salzsieder, Eckhard, Grimm, Rita, Giebel, Jürgen, Salzsieder, Christel, Harrison, Leonard C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Chloromethyl Ketones - pharmacology Animals Apoptosis Caspase Inhibitors Caspases - metabolism Cell Line Enzyme Inhibitors - pharmacology Fas Ligand Protein - metabolism Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - enzymology Insulin-Secreting Cells - immunology Insulin-Secreting Cells - pathology Interferon-gamma - metabolism Interleukin-1beta - metabolism Membrane Potential, Mitochondrial Mice Mitochondria - drug effects Mitochondria - enzymology Mitochondria - immunology Mitochondria - pathology NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide - metabolism Nitric Oxide Synthase Type II - antagonists & inhibitors Nitric Oxide Synthase Type II - metabolism Nitrites - metabolism Recombinant Proteins - metabolism Time Factors
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