The combined effects of celecoxib and minocycline hydrochloride on inhibiting the osseous metastasis of breast cancer in nude mice

Breast carcinomas show a trend toward bone metastasis that is prevalent worldwide. Celecoxib (CX) and minocycline hydrochloride (MH) have both been widely used in treating breast cancer; however, their combined effects on the osseous metastasis of breast cancer have not yet been studied. In the pres...

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Veröffentlicht in:	Cancer biotherapy & radiopharmaceuticals 2008-08, Vol.23 (4), p.469-476
Hauptverfasser:	Niu, Guangfeng, Liao, Zhichao, Cai, Lin, Wei, Renxiong, Sun, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - blood Animals Apoptosis - drug effects Body Weight - drug effects Bone Neoplasms - drug therapy Bone Neoplasms - metabolism Bone Neoplasms - secondary Breast Neoplasms - pathology Celecoxib Cell Line, Tumor Cyclooxygenase Inhibitors - therapeutic use Drug Therapy, Combination Female Humans Matrix Metalloproteinase 9 - metabolism Mice Mice, Inbred Strains Mice, Nude Minocycline - pharmacology Minocycline - therapeutic use Pyrazoles - pharmacology Pyrazoles - therapeutic use Sulfonamides - pharmacology Sulfonamides - therapeutic use Tumor Burden - drug effects Vascular Endothelial Growth Factor A - metabolism Xenograft Model Antitumor Assays - methods
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