Transcriptional control of skeletogenesis
The skeleton contains three specific cell types: chondrocytes in cartilage and osteoblasts and osteoclasts in bone. Our understanding of the transcriptional mechanisms that lead to cell differentiation along these three lineages has increased considerably in the past ten years. In the case of chondr...
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| Veröffentlicht in: | Annual review of genomics and human genetics 2008-01, Vol.9 (1), p.183-196 |
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| container_title | Annual review of genomics and human genetics |
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| creator | Karsenty, Gerard |
| description | The skeleton contains three specific cell types: chondrocytes in cartilage and osteoblasts and osteoclasts in bone. Our understanding of the transcriptional mechanisms that lead to cell differentiation along these three lineages has increased considerably in the past ten years. In the case of chondrocytes and osteoblasts advances have been made possible largely through the molecular elucidation of human skeletal dysplasias. This review discusses the key transcription factors that regulate skeletogenesis and highlights their function, mode of action, and regulation by other factors, with a special emphasis on how human genetics has contributed to this knowledge. |
| doi_str_mv | 10.1146/annurev.genom.9.081307.164437 |
| format | Article |
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| ispartof | Annual review of genomics and human genetics, 2008-01, Vol.9 (1), p.183-196 |
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| language | eng |
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| source | Annual Reviews; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Activating Transcription Factor 4 - genetics Animals Bone Development - genetics Bone Diseases, Developmental - genetics Cell Differentiation - genetics Chondrogenesis - genetics Core Binding Factor Alpha 1 Subunit - genetics Humans Mice Models, Genetic Osteoblasts - cytology Osteoblasts - metabolism Osteogenesis - genetics Sp7 Transcription Factor Transcription Factor AP-1 - genetics Transcription Factors - genetics Transcription, Genetic |
| title | Transcriptional control of skeletogenesis |
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