Development of scintillation-proximity assays for alpha adrenoceptors

Binding assays have long been used to determine compound affinity and selectivity for various seven-transmembrane receptors. Over time, the degree of complexity has significantly reduced, whereas the throughput of the various assays has greatly increased. In this article, we detail the development o...

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Veröffentlicht in:	Journal of pharmacological and toxicological methods 1999-12, Vol.42 (4), p.237-244
Hauptverfasser:	Gobel, Jeff, Saussy, David L, Goetz, Aaron S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Agonists - metabolism Adrenergic alpha-Antagonists - metabolism Animals Binding, Competitive - drug effects Binding, Competitive - physiology CHO Cells - metabolism Cricetinae Fibroblasts - metabolism Filter binding Rats Receptors, Adrenergic, alpha - metabolism Scintillation Counting - methods Scintillation-proximity assay (SPA) α-Adrenoceptors
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