Determination of reference values for a novel ketoamine-specific fructosamine assay for assessment of diabetic glycemic control
Intensive monitoring to improve glycemic control is essential for effective management of diabetes and reduction of long-term morbidity and pathology. Measurement of glycated serum proteins (fructosamine) allows more frequent assessment (monthly) of glycemic control than the 2- to 3-month window of...
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| Veröffentlicht in: | Diabetes technology & therapeutics 1999, Vol.1 (4), p.447-455 |
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| creator | O'Brien, J E Brookes, M |
| description | Intensive monitoring to improve glycemic control is essential for effective management of diabetes and reduction of long-term morbidity and pathology. Measurement of glycated serum proteins (fructosamine) allows more frequent assessment (monthly) of glycemic control than the 2- to 3-month window of the traditional glycated hemoglobin (HbA1c) assay. In response to concerns about assays designed to measure glycated serum proteins based on the nitroblue tetrazolium (NBT) methodology, a novel assay to measure glycated serum proteins has been developed based on the specific oxidation of the ketoamine bonds within the glycated proteins.
Reference range values for this new, enzymatic glycated-serum-protein assay (GlyPro; Genzyme Corporation, Cambridge, MA) are reported.
The GlyPro reference range is lower and shows close correlation with ranges reported for the NBT assay. The 95% overall reference range was 122 to 236 mumol/L.
GlyPro is a reliable, accurate assay and correlates well with the NBT assay for the measurement of glycated serum proteins. The assay may be useful in the short-term assessment of diabetes control, a necessary complement to long-term control as assessed by hemoglobin A1c (HbA1c) assays. |
| doi_str_mv | 10.1089/152091599316982 |
| format | Article |
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Reference range values for this new, enzymatic glycated-serum-protein assay (GlyPro; Genzyme Corporation, Cambridge, MA) are reported.
The GlyPro reference range is lower and shows close correlation with ranges reported for the NBT assay. The 95% overall reference range was 122 to 236 mumol/L.
GlyPro is a reliable, accurate assay and correlates well with the NBT assay for the measurement of glycated serum proteins. The assay may be useful in the short-term assessment of diabetes control, a necessary complement to long-term control as assessed by hemoglobin A1c (HbA1c) assays.</description><identifier>ISSN: 1520-9156</identifier><identifier>EISSN: 1557-8593</identifier><identifier>DOI: 10.1089/152091599316982</identifier><identifier>PMID: 11474831</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Biomarkers - blood ; Blood Glucose - metabolism ; Diabetes Mellitus - blood ; Female ; Fructosamine - blood ; Glycated Hemoglobin A - analysis ; Humans ; Male ; Middle Aged ; Monitoring, Physiologic - methods ; Reference Standards ; Reference Values ; Regression Analysis ; Reproducibility of Results ; Sensitivity and Specificity</subject><ispartof>Diabetes technology & therapeutics, 1999, Vol.1 (4), p.447-455</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c208t-3fd9a97517c6ffd39ca97310480ad2612a86ca7df3f77bc2ae5649af01847dde3</citedby><cites>FETCH-LOGICAL-c208t-3fd9a97517c6ffd39ca97310480ad2612a86ca7df3f77bc2ae5649af01847dde3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3029,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11474831$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>O'Brien, J E</creatorcontrib><creatorcontrib>Brookes, M</creatorcontrib><title>Determination of reference values for a novel ketoamine-specific fructosamine assay for assessment of diabetic glycemic control</title><title>Diabetes technology & therapeutics</title><addtitle>Diabetes Technol Ther</addtitle><description>Intensive monitoring to improve glycemic control is essential for effective management of diabetes and reduction of long-term morbidity and pathology. Measurement of glycated serum proteins (fructosamine) allows more frequent assessment (monthly) of glycemic control than the 2- to 3-month window of the traditional glycated hemoglobin (HbA1c) assay. In response to concerns about assays designed to measure glycated serum proteins based on the nitroblue tetrazolium (NBT) methodology, a novel assay to measure glycated serum proteins has been developed based on the specific oxidation of the ketoamine bonds within the glycated proteins.
Reference range values for this new, enzymatic glycated-serum-protein assay (GlyPro; Genzyme Corporation, Cambridge, MA) are reported.
The GlyPro reference range is lower and shows close correlation with ranges reported for the NBT assay. The 95% overall reference range was 122 to 236 mumol/L.
GlyPro is a reliable, accurate assay and correlates well with the NBT assay for the measurement of glycated serum proteins. The assay may be useful in the short-term assessment of diabetes control, a necessary complement to long-term control as assessed by hemoglobin A1c (HbA1c) assays.</description><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Blood Glucose - metabolism</subject><subject>Diabetes Mellitus - blood</subject><subject>Female</subject><subject>Fructosamine - blood</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Monitoring, Physiologic - methods</subject><subject>Reference Standards</subject><subject>Reference Values</subject><subject>Regression Analysis</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><issn>1520-9156</issn><issn>1557-8593</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkL1PwzAQxS0EoqUwsyFPbKF2HMf2iMqnVIkF5si1zyiQxMV2KnXiX8ellZCY7t3d7550D6FLSm4okWpOeUkU5UoxWitZHqEp5VwUkit2vNMlKfK6nqCzGD8IIYKV9BRNKK1EJRmdou87SBD6dtCp9QP2DgdwEGAwgDe6GyFi5wPWePAb6PAnJK8zDUVcg2lda7ALo0k-_k6xjlFv9xcxQow9DGlnalu9gpTp925roM_C-CEF352jE6e7CBeHOkNvD_evi6di-fL4vLhdFqYkMhXMWaWV4FSY2jnLlMkdo6SSRNuypqWWtdHCOuaEWJlSA68rpR2hshLWApuh673vOviv_FVq-jYa6Do9gB9jUyue3QjP4HwPmuBjzGE069D2OmwbSppd5s2_zPPF1cF6XPVg__hDyOwHVv1_Mw</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>O'Brien, J E</creator><creator>Brookes, M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1999</creationdate><title>Determination of reference values for a novel ketoamine-specific fructosamine assay for assessment of diabetic glycemic control</title><author>O'Brien, J E ; Brookes, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c208t-3fd9a97517c6ffd39ca97310480ad2612a86ca7df3f77bc2ae5649af01847dde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>Blood Glucose - metabolism</topic><topic>Diabetes Mellitus - blood</topic><topic>Female</topic><topic>Fructosamine - blood</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Monitoring, Physiologic - methods</topic><topic>Reference Standards</topic><topic>Reference Values</topic><topic>Regression Analysis</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O'Brien, J E</creatorcontrib><creatorcontrib>Brookes, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes technology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'Brien, J E</au><au>Brookes, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of reference values for a novel ketoamine-specific fructosamine assay for assessment of diabetic glycemic control</atitle><jtitle>Diabetes technology & therapeutics</jtitle><addtitle>Diabetes Technol Ther</addtitle><date>1999</date><risdate>1999</risdate><volume>1</volume><issue>4</issue><spage>447</spage><epage>455</epage><pages>447-455</pages><issn>1520-9156</issn><eissn>1557-8593</eissn><abstract>Intensive monitoring to improve glycemic control is essential for effective management of diabetes and reduction of long-term morbidity and pathology. Measurement of glycated serum proteins (fructosamine) allows more frequent assessment (monthly) of glycemic control than the 2- to 3-month window of the traditional glycated hemoglobin (HbA1c) assay. In response to concerns about assays designed to measure glycated serum proteins based on the nitroblue tetrazolium (NBT) methodology, a novel assay to measure glycated serum proteins has been developed based on the specific oxidation of the ketoamine bonds within the glycated proteins.
Reference range values for this new, enzymatic glycated-serum-protein assay (GlyPro; Genzyme Corporation, Cambridge, MA) are reported.
The GlyPro reference range is lower and shows close correlation with ranges reported for the NBT assay. The 95% overall reference range was 122 to 236 mumol/L.
GlyPro is a reliable, accurate assay and correlates well with the NBT assay for the measurement of glycated serum proteins. The assay may be useful in the short-term assessment of diabetes control, a necessary complement to long-term control as assessed by hemoglobin A1c (HbA1c) assays.</abstract><cop>United States</cop><pmid>11474831</pmid><doi>10.1089/152091599316982</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 1520-9156 |
| ispartof | Diabetes technology & therapeutics, 1999, Vol.1 (4), p.447-455 |
| issn | 1520-9156 1557-8593 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69510405 |
| source | Mary Ann Liebert Online Subscription; MEDLINE |
| subjects | Adult Biomarkers - blood Blood Glucose - metabolism Diabetes Mellitus - blood Female Fructosamine - blood Glycated Hemoglobin A - analysis Humans Male Middle Aged Monitoring, Physiologic - methods Reference Standards Reference Values Regression Analysis Reproducibility of Results Sensitivity and Specificity |
| title | Determination of reference values for a novel ketoamine-specific fructosamine assay for assessment of diabetic glycemic control |
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