Pretransplant Infusion of Mesenchymal Stem Cells Prolongs the Survival of a Semiallogeneic Heart Transplant through the Generation of Regulatory T Cells

In this study, we investigated whether mesenchymal stem cells (MSC) had immunomodulatory properties in solid organ allotransplantation, using a semiallogeneic heart transplant mouse model, and studied the mechanism(s) underlying MSC tolerogenic effects. Either single (portal vein, day -7) or double...

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Veröffentlicht in:	The Journal of immunology (1950) 2008-09, Vol.181 (6), p.3933-3946
Hauptverfasser:	Casiraghi, Federica, Azzollini, Nadia, Cassis, Paola, Imberti, Barbara, Morigi, Marina, Cugini, Daniela, Cavinato, Regiane Aparecida, Todeschini, Marta, Solini, Samantha, Sonzogni, Aurelio, Perico, Norberto, Remuzzi, Giuseppe, Noris, Marina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Cells - immunology Cell Differentiation - immunology Female Graft Survival - immunology Heart Transplantation - immunology Heart Transplantation - methods Male Mesenchymal Stem Cell Transplantation - methods Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - immunology Transplantation Conditioning - methods Transplantation Tolerance - immunology Transplantation, Heterotopic Transplantation, Homologous Transplantation, Isogeneic
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