Poly(amidoamine)s as Potential Endosomolytic Polymers: Evaluation In Vitro and Body Distribution in Normal and Tumour-Bearing Animals

Abstract Fusogenic peptides derived from viral coat proteins cause perturbation of the endosomal membrane and are often used to improve the transfection efficiency of non-viral vectors in vitro. However, fusogenic peptides have limited potential for use in vivo due to their inherent immunogenicity....

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Veröffentlicht in:	Journal of drug targeting 1999, Vol.6 (6), p.391-404
Hauptverfasser:	Richardson, S., Ferruti, P., Duncan, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocompatibility Biocompatible Materials Biological and medical sciences Cell Survival - drug effects Drug delivery Endosomes - drug effects Erythrocytes - drug effects General pharmacology Hemolysis - drug effects Humans Hydrogen-Ion Concentration In Vitro Techniques Iodine Radioisotopes Materials Testing Medical sciences Membrane activity Microscopy, Electron, Scanning Neoplasm Transplantation Neoplasms, Experimental - metabolism Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Poly(amidoamine) Polymers Rats Tissue Distribution Tumor Cells, Cultured
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