Effects of topical application of taurolidine on second intention healing of experimentally induced wounds in rats
To determine the macroscopic effects of topical application of taurolidine on second intention healing of experimentally induced wounds in rats. 32 adult Sprague-Dawley female rats. In each rat, 2 skin wounds were created in the lumbar area. Groups of 7 rats were assigned to have 1 wound treated top...
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| Veröffentlicht in: | American journal of veterinary research 2008-09, Vol.69 (9), p.1210-1216 |
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| creator | Simpson, Jennifer M Seguin, Bernard Gitelman, Alix I |
| description | To determine the macroscopic effects of topical application of taurolidine on second intention healing of experimentally induced wounds in rats.
32 adult Sprague-Dawley female rats.
In each rat, 2 skin wounds were created in the lumbar area. Groups of 7 rats were assigned to have 1 wound treated topically with hydroxycellulose gel (HDCG), 2% taurolidine in HDCG (T-HDCG), 2% taurolidine-sodium citrate solution, or bacitracin-neomycin-polymyxin B ointment; the other wound was not treated. Four control rats (8 untreated wounds) were used. Wounds were monitored for contraction, epithelialization, and complete healing at 4, 8, and 14 days after wound creation. The number of days to complete healing was also recorded for each wound.
Compared with other treatments or untreated wounds, wounds treated with T-HDCG had decreased total healing at day 8 and decreased epithelialization and decreased total healing at day 14. Wounds treated with T-HDCG required approximately 3 days longer to completely heal than all other treated and untreated wounds. Application of bacitracinneomycin-polymyxin B ointment did not enhance wound healing. Mean time to complete healing of untreated wounds in all treatment and control groups was 10.00 to 10.14 days.
In rats, topical application of T-HDCG to wounds had a negative effect on second intention healing by delaying the epithelialization process. In mammals, generally, wounds treated topically with taurolidine may need to be treated and monitored for a longer period than other wounds treated with other common woundhealing compounds or untreated wounds. |
| doi_str_mv | 10.2460/ajvr.69.9.1210 |
| format | Article |
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32 adult Sprague-Dawley female rats.
In each rat, 2 skin wounds were created in the lumbar area. Groups of 7 rats were assigned to have 1 wound treated topically with hydroxycellulose gel (HDCG), 2% taurolidine in HDCG (T-HDCG), 2% taurolidine-sodium citrate solution, or bacitracin-neomycin-polymyxin B ointment; the other wound was not treated. Four control rats (8 untreated wounds) were used. Wounds were monitored for contraction, epithelialization, and complete healing at 4, 8, and 14 days after wound creation. The number of days to complete healing was also recorded for each wound.
Compared with other treatments or untreated wounds, wounds treated with T-HDCG had decreased total healing at day 8 and decreased epithelialization and decreased total healing at day 14. Wounds treated with T-HDCG required approximately 3 days longer to completely heal than all other treated and untreated wounds. Application of bacitracinneomycin-polymyxin B ointment did not enhance wound healing. Mean time to complete healing of untreated wounds in all treatment and control groups was 10.00 to 10.14 days.
In rats, topical application of T-HDCG to wounds had a negative effect on second intention healing by delaying the epithelialization process. In mammals, generally, wounds treated topically with taurolidine may need to be treated and monitored for a longer period than other wounds treated with other common woundhealing compounds or untreated wounds.</description><identifier>ISSN: 0002-9645</identifier><identifier>EISSN: 1943-5681</identifier><identifier>DOI: 10.2460/ajvr.69.9.1210</identifier><identifier>PMID: 18764696</identifier><language>eng</language><publisher>United States</publisher><subject>Administration, Cutaneous ; adverse effects ; Analysis of Variance ; Animals ; Anti-Infective Agents - pharmacology ; antimicrobial agents ; bioactive properties ; body regions ; diseases and disorders (animals and humans) ; drug evaluation ; drug therapy ; epithelium ; Female ; histology ; lumbar spine ; microscopy ; physiological response ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; skin ; Taurine - analogs & derivatives ; Taurine - pharmacology ; taurolidine ; Thiadiazines - pharmacology ; Time Factors ; tissue analysis ; tissue repair ; topical application ; Wound Healing - drug effects ; wounds and injuries</subject><ispartof>American journal of veterinary research, 2008-09, Vol.69 (9), p.1210-1216</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-3ae0cb60b524ac327b00b020d8b6f67a4b85cce26bc6f27d4d88c9d897aa3c823</citedby><cites>FETCH-LOGICAL-c357t-3ae0cb60b524ac327b00b020d8b6f67a4b85cce26bc6f27d4d88c9d897aa3c823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18764696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Simpson, Jennifer M</creatorcontrib><creatorcontrib>Seguin, Bernard</creatorcontrib><creatorcontrib>Gitelman, Alix I</creatorcontrib><title>Effects of topical application of taurolidine on second intention healing of experimentally induced wounds in rats</title><title>American journal of veterinary research</title><addtitle>Am J Vet Res</addtitle><description>To determine the macroscopic effects of topical application of taurolidine on second intention healing of experimentally induced wounds in rats.
32 adult Sprague-Dawley female rats.
In each rat, 2 skin wounds were created in the lumbar area. Groups of 7 rats were assigned to have 1 wound treated topically with hydroxycellulose gel (HDCG), 2% taurolidine in HDCG (T-HDCG), 2% taurolidine-sodium citrate solution, or bacitracin-neomycin-polymyxin B ointment; the other wound was not treated. Four control rats (8 untreated wounds) were used. Wounds were monitored for contraction, epithelialization, and complete healing at 4, 8, and 14 days after wound creation. The number of days to complete healing was also recorded for each wound.
Compared with other treatments or untreated wounds, wounds treated with T-HDCG had decreased total healing at day 8 and decreased epithelialization and decreased total healing at day 14. Wounds treated with T-HDCG required approximately 3 days longer to completely heal than all other treated and untreated wounds. Application of bacitracinneomycin-polymyxin B ointment did not enhance wound healing. Mean time to complete healing of untreated wounds in all treatment and control groups was 10.00 to 10.14 days.
In rats, topical application of T-HDCG to wounds had a negative effect on second intention healing by delaying the epithelialization process. In mammals, generally, wounds treated topically with taurolidine may need to be treated and monitored for a longer period than other wounds treated with other common woundhealing compounds or untreated wounds.</description><subject>Administration, Cutaneous</subject><subject>adverse effects</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>antimicrobial agents</subject><subject>bioactive properties</subject><subject>body regions</subject><subject>diseases and disorders (animals and humans)</subject><subject>drug evaluation</subject><subject>drug therapy</subject><subject>epithelium</subject><subject>Female</subject><subject>histology</subject><subject>lumbar spine</subject><subject>microscopy</subject><subject>physiological response</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>skin</subject><subject>Taurine - analogs & derivatives</subject><subject>Taurine - pharmacology</subject><subject>taurolidine</subject><subject>Thiadiazines - pharmacology</subject><subject>Time Factors</subject><subject>tissue analysis</subject><subject>tissue repair</subject><subject>topical application</subject><subject>Wound Healing - drug effects</subject><subject>wounds and injuries</subject><issn>0002-9645</issn><issn>1943-5681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0EFPHSEQB3DS1NRX9dqj7qm3XQeWZeFojFUTkx5az2QWWIvhLSvsVv325fle0hPD8GOS-RPyjULDuIBLfP6bGqEa1VBG4RPZUMXbuhOSfiYbAGC1Erw7Jl9zfgagTNLuCzmmshdcKLEh6WYcnVlyFcdqibM3GCqc51CKxcfpo41risFbP7mqdLIzcbKVnxY3fZA_DoOfnnbUvc0u-W15wBDei7GrcbZ6jetkc7lWCZd8So5GDNmdHc4T8vjj5vf1Xf3w8_b--uqhNm3XL3WLDswgYOgYR9OyfgAYgIGVgxhFj3yQnTGOicGIkfWWWymNslL1iK2RrD0h3_dz5xRfVpcXvfXZuBBwcnHNWiiuFKO8wGYPTYo5JzfquSyB6V1T0LuU9S7l4rXSu5TLh_PD5HXYOvufH2It4GIPRowan5LP-vEXA9oC7XgnSvEPlGOFBA</recordid><startdate>20080901</startdate><enddate>20080901</enddate><creator>Simpson, Jennifer M</creator><creator>Seguin, Bernard</creator><creator>Gitelman, Alix I</creator><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080901</creationdate><title>Effects of topical application of taurolidine on second intention healing of experimentally induced wounds in rats</title><author>Simpson, Jennifer M ; Seguin, Bernard ; Gitelman, Alix I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-3ae0cb60b524ac327b00b020d8b6f67a4b85cce26bc6f27d4d88c9d897aa3c823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Administration, Cutaneous</topic><topic>adverse effects</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>antimicrobial agents</topic><topic>bioactive properties</topic><topic>body regions</topic><topic>diseases and disorders (animals and humans)</topic><topic>drug evaluation</topic><topic>drug therapy</topic><topic>epithelium</topic><topic>Female</topic><topic>histology</topic><topic>lumbar spine</topic><topic>microscopy</topic><topic>physiological response</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>skin</topic><topic>Taurine - analogs & derivatives</topic><topic>Taurine - pharmacology</topic><topic>taurolidine</topic><topic>Thiadiazines - pharmacology</topic><topic>Time Factors</topic><topic>tissue analysis</topic><topic>tissue repair</topic><topic>topical application</topic><topic>Wound Healing - drug effects</topic><topic>wounds and injuries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Simpson, Jennifer M</creatorcontrib><creatorcontrib>Seguin, Bernard</creatorcontrib><creatorcontrib>Gitelman, Alix I</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of veterinary research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Simpson, Jennifer M</au><au>Seguin, Bernard</au><au>Gitelman, Alix I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of topical application of taurolidine on second intention healing of experimentally induced wounds in rats</atitle><jtitle>American journal of veterinary research</jtitle><addtitle>Am J Vet Res</addtitle><date>2008-09-01</date><risdate>2008</risdate><volume>69</volume><issue>9</issue><spage>1210</spage><epage>1216</epage><pages>1210-1216</pages><issn>0002-9645</issn><eissn>1943-5681</eissn><abstract>To determine the macroscopic effects of topical application of taurolidine on second intention healing of experimentally induced wounds in rats.
32 adult Sprague-Dawley female rats.
In each rat, 2 skin wounds were created in the lumbar area. Groups of 7 rats were assigned to have 1 wound treated topically with hydroxycellulose gel (HDCG), 2% taurolidine in HDCG (T-HDCG), 2% taurolidine-sodium citrate solution, or bacitracin-neomycin-polymyxin B ointment; the other wound was not treated. Four control rats (8 untreated wounds) were used. Wounds were monitored for contraction, epithelialization, and complete healing at 4, 8, and 14 days after wound creation. The number of days to complete healing was also recorded for each wound.
Compared with other treatments or untreated wounds, wounds treated with T-HDCG had decreased total healing at day 8 and decreased epithelialization and decreased total healing at day 14. Wounds treated with T-HDCG required approximately 3 days longer to completely heal than all other treated and untreated wounds. Application of bacitracinneomycin-polymyxin B ointment did not enhance wound healing. Mean time to complete healing of untreated wounds in all treatment and control groups was 10.00 to 10.14 days.
In rats, topical application of T-HDCG to wounds had a negative effect on second intention healing by delaying the epithelialization process. In mammals, generally, wounds treated topically with taurolidine may need to be treated and monitored for a longer period than other wounds treated with other common woundhealing compounds or untreated wounds.</abstract><cop>United States</cop><pmid>18764696</pmid><doi>10.2460/ajvr.69.9.1210</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Administration, Cutaneous adverse effects Analysis of Variance Animals Anti-Infective Agents - pharmacology antimicrobial agents bioactive properties body regions diseases and disorders (animals and humans) drug evaluation drug therapy epithelium Female histology lumbar spine microscopy physiological response Random Allocation Rats Rats, Sprague-Dawley skin Taurine - analogs & derivatives Taurine - pharmacology taurolidine Thiadiazines - pharmacology Time Factors tissue analysis tissue repair topical application Wound Healing - drug effects wounds and injuries |
| title | Effects of topical application of taurolidine on second intention healing of experimentally induced wounds in rats |
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