Down-regulated expression of plant-specific glycoepitopes in alfalfa

Compared with other plant expression systems used for pharmaceutical protein production, alfalfa offers the advantage of very homogeneous N-glycosylation. Therefore, this plant was selected for further attempts at glycoengineering. Two main approaches were developed in order to humanize N-glycosylat...

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Veröffentlicht in:	Plant biotechnology journal 2008-09, Vol.6 (7), p.702-721
Hauptverfasser:	Sourrouille, Christophe, Marquet-Blouin, Estelle, D'Aoust, Marc-André, Kiefer-Meyer, Marie-Christine, Seveno, Martial, Pagny-Salehabadi, Sophie, Bardor, Muriel, Durambur, Gaelle, Lerouge, Patrice, Vezina, Louis, Gomord, Véronique
Format:	Artikel
Sprache:	eng
Schlagworte:	alfalfa Amino Acid Sequence Animals Biological and medical sciences Biotechnology Cell Line Cloning, Molecular Down-Regulation Epitopes - genetics Epitopes - immunology Fucosyltransferases - antagonists & inhibitors Fucosyltransferases - chemistry Fucosyltransferases - genetics Fundamental and applied biological sciences. Psychology Galactosyltransferases - genetics Galactosyltransferases - metabolism glycoengineering Glycoproteins - chemistry Glycoproteins - genetics Glycoproteins - metabolism Glycosylation glycosyltransferase Humans Lewis a epitope Medicago sativa - genetics Medicago sativa - metabolism Molecular Sequence Data N-Acetylglucosaminyltransferases - chemistry N-Acetylglucosaminyltransferases - genetics N-Acetylglucosaminyltransferases - metabolism N-glycosylation Nicotiana - genetics Pentosyltransferases - antagonists & inhibitors Pentosyltransferases - chemistry Pentosyltransferases - genetics Plant Proteins - antagonists & inhibitors Plant Proteins - genetics Plant Proteins - metabolism plant-made pharmaceutical Plants, Genetically Modified - metabolism Recombinant Fusion Proteins - metabolism RNA Interference Sequence Alignment Spodoptera Substrate Specificity
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