Modulation of cholinergic contractions of airway smooth muscle by cathinone: potential beneficial effects in airway diseases
Infusion of khat leaves is an African traditional remedy used to treat airway diseases. The beneficial effects of khat are thought to be due to the activity of its main active component, cathinone. Cathinone inhibited electric field stimulation-induced acetylcholine release and the contractions of s...
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| Veröffentlicht in: | The European respiratory journal 2008-09, Vol.32 (3), p.579-584 |
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| container_end_page | 584 |
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| container_title | The European respiratory journal |
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| creator | Freund-Michel, V. C Birrell, M. A Patel, H. J Murray-Lyon, I. M Belvisi, M. G |
| description | Infusion of khat leaves is an African traditional remedy used to treat airway diseases. The beneficial effects of khat are thought to be due to the activity of its main active component, cathinone. Cathinone inhibited electric field stimulation-induced acetylcholine release and the contractions of smooth muscle, which could be responsible for the beneficial effects seen in airway disease. The mechanism of action of this natural product appears to be via the activation of both pre-junctional alpha(2) adrenergic and 5-hydroxytryptamine 7 receptors. The present novel study describes how cathinone modulates airway tone, and may go some way to explaining the traditional use of khat as a remedy for the alleviation of respiratory disease symptoms. In conclusion, cathinone may have beneficial effects in airway diseases with heightened cholinergic tone. There is some rationale for follow-up of these observations, given previous experience of other traditional remedies being developed for therapeutic use. |
| doi_str_mv | 10.1183/09031936.00162707 |
| format | Article |
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In conclusion, cathinone may have beneficial effects in airway diseases with heightened cholinergic tone. 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The present novel study describes how cathinone modulates airway tone, and may go some way to explaining the traditional use of khat as a remedy for the alleviation of respiratory disease symptoms. In conclusion, cathinone may have beneficial effects in airway diseases with heightened cholinergic tone. There is some rationale for follow-up of these observations, given previous experience of other traditional remedies being developed for therapeutic use.</description><subject>Alkaloids - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Central Nervous System Stimulants - pharmacology</subject><subject>Guinea Pigs</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Lung - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle, Smooth - drug effects</subject><subject>Parasympathetic Nervous System - drug effects</subject><subject>Pneumology</subject><subject>Trachea - drug effects</subject><subject>Vas Deferens - drug effects</subject><issn>0903-1936</issn><issn>1399-3003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtv1DAUhS0EokPhB7BB3sAuxa9xYnaoKg-piA2srRvnpnHl2IPtqBqJH0-iztDVvdL5zpHOIeQtZ1ecd_IjM0xyI_UVY1yLlrXPyI5LYxrJmHxOdpvebMAFeVXK_UYpyV-SC961-1YbvSN_f6RhCVB9ijSN1E0p-Ij5zjvqUqwZ3CaVTQOfH-BIy5xSnei8FBeQ9kfqoE4-poif6CFVjNVDoD1GHL3bXhxHdLVQH88Rgy8IBctr8mKEUPDN6V6S319ufl1_a25_fv1-_fm2cYqJ2vTAtRZStU6rXqpO9CDXKqZjrJfOsFH3XKPqAE0nFFPSdO0A3dDzUTgQUl6SD4-5h5z-LFiqnX1xGAJETEux2igjdKdWkD-CLqdSMo72kP0M-Wg5s9vk9jy5PU--et6dwpd-xuHJcdp4Bd6fACgOwpghOl_-c4LtDV8LPnGTv5sefEZbZghhjeUW870UVtp9a-Q_okqXQw</recordid><startdate>20080901</startdate><enddate>20080901</enddate><creator>Freund-Michel, V. 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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Alkaloids - pharmacology Animals Biological and medical sciences Central Nervous System Stimulants - pharmacology Guinea Pigs Humans In Vitro Techniques Lung - drug effects Male Medical sciences Muscle Contraction - drug effects Muscle, Smooth - drug effects Parasympathetic Nervous System - drug effects Pneumology Trachea - drug effects Vas Deferens - drug effects |
| title | Modulation of cholinergic contractions of airway smooth muscle by cathinone: potential beneficial effects in airway diseases |
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