Downregulation of muscle protein degradation in sepsis by eicosapentaenoic acid (EPA)

Eicosapentaenoic acid (EPA) has been shown to attenuate muscle atrophy in cancer, starvation and hyperthermia by downregulating the increased expression of the ubiquitin–proteasome proteolytic pathway leading to a reduction in protein degradation. In the current study EPA (0.5 g/kg) administered to...

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Veröffentlicht in:	Biochemical and biophysical research communications 2008-10, Vol.375 (2), p.238-240
Hauptverfasser:	Khal, Jwan, Tisdale, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cysteine Endopeptidases - genetics Cysteine Endopeptidases - metabolism Disease Models, Animal Down-Regulation Eicosapentaenoic Acid - pharmacology EPA Mice Muscle atrophy Muscle Fibers, Skeletal - drug effects Muscle Fibers, Skeletal - metabolism Muscle Proteins - metabolism Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscular Atrophy - etiology Muscular Atrophy - metabolism Muscular Atrophy - microbiology Proteasome Endopeptidase Complex - drug effects Proteasome Endopeptidase Complex - genetics Proteasome Endopeptidase Complex - metabolism Protein Biosynthesis - drug effects RNA, Messenger - biosynthesis Sepsis Sepsis - complications Sepsis - metabolism Staphylococcus aureus Ubiquitin–proteasome proteolysis
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