A roadmap for drug discovery and its translation to small molecule agents in clinical development for tuberculosis treatment

Summary Drug discovery and development, from an initial disease treatment concept to a new drug application (NDA), is a complex, lengthy and expensive process. In this review we discuss the key stages of drug discovery and early development, including target identification and validation, assay deve...

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Veröffentlicht in:	Tuberculosis (Edinburgh, Scotland) Scotland), 2008-08, Vol.88, p.S3-S17
Hauptverfasser:	Showalter, H.D. Hollis, Denny, William A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use Diarylquinolines Drug Design Drug discovery Drug Evaluation - methods Drug Evaluation, Preclinical - methods Drug Therapy, Combination Drugs, Investigational - therapeutic use Fluoroquinolones Humans Infectious Disease Mycobacterium Mycobacterium tuberculosis - drug effects Nitroimidazooxazines Nitroimidazooxazoles Oxazolidinones Pulmonary/Respiratory Tuberculosis Tuberculosis - drug therapy
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