A combination of genetic suppressor elements produces resistance to drugs inhibiting DNA replication

Many anticancer drugs inhibit DNA replication. To investigate the mechanism of permanent growth inhibition after transient arrest of DNA replication, we selected genetic suppressor elements (GSEs) conferring resistance to replication inhibitor Aphidicolin. Starting from a retroviral expression libra...

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Veröffentlicht in:	Somatic cell and molecular genetics 1999-01, Vol.25 (1), p.9-26
Hauptverfasser:	Levenson, V V, Lausch, E, Kirschling, D J, Broude, E V, Davidovich, I A, Libants, S, Fedosova, V, Roninson, I B
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology aphidicolin Aphidicolin - pharmacology Base Sequence DNA Replication - drug effects DNA, Antisense - genetics DNA, Complementary - genetics DNA, Complementary - isolation & purification doxorubicin Doxorubicin - pharmacology Drug Resistance - genetics Gene Library Genes, Suppressor HeLa Cells Humans hydroxyurea Hydroxyurea - pharmacology Molecular Sequence Data Tumor Cells, Cultured
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