Effective CpG Immunotherapy of Breast Carcinoma Prevents but Fails to Eradicate Established Brain Metastasis

Purpose: Breast cancer patients with brain metastasis have a dismal prognosis. We determined the ability of immunostimulatory CpG oligodeoxynucleotides (ODN) to treat or prevent brain metastasis in a mouse model. Experimental Design: Mice bearing orthotopic breast carcinoma with or without concurren...

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Veröffentlicht in:	Clinical cancer research 2008-09, Vol.14 (17), p.5484-5493
Hauptverfasser:	ZHENGMING XIONG, GHARAGOZLOU, Soheila, VENGCO, Isabelita, WEI CHEN, OHLFESTL, John R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Animals Antineoplastic agents Biological and medical sciences Brain Metastasis Brain Neoplasms - immunology Brain Neoplasms - prevention & control Brain Neoplasms - secondary Brain Neoplasms - therapy Brain Tumor Breast Cancer Cell Line, Tumor CpG ODN Cytotoxicity, Immunologic Female Gynecology. Andrology. Obstetrics Immunotherapy Immunotherapy - methods Mammary gland diseases Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - immunology Mammary Neoplasms, Experimental - therapy Medical sciences Mice Mice, Inbred BALB C Neurology Oligodeoxyribonucleotides - therapeutic use Pharmacology. Drug treatments T-Lymphocytes, Cytotoxic - immunology Tumors Tumors of the nervous system. Phacomatoses
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