In-vitro and in-vivo evaluation of enteric-coated starch-based pellets prepared via extrusion/spheronisation

Pellet cores containing modified starch (high-amylose, crystalline and resistant starch) as the main excipient were enteric-coated with an Eudragit ® L30 D-55 based dispersion. The polymer weight gain was from 15% to 30% (w/w). Pellet cores were prepared using piroxicam (2.5% w/w, poor water solubil...

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