Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways

A family of Mastermind-like ( MAML ) genes encodes critical transcriptional co-activators for Notch signaling, an evolutionarily conserved pathway with numerous roles in both development and human diseases. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shut...

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Veröffentlicht in:	Oncogene 2008-09, Vol.27 (38), p.5138-5147
Hauptverfasser:	McElhinny, A S, Li, J-L, Wu, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - physiopathology Animals Apoptosis beta Catenin - physiology Cancer Cell Biology Cell Communication - physiology Cell Differentiation - physiology Cellular biology Cellular signal transduction Colonic Neoplasms - physiopathology DNA-Binding Proteins - chemistry DNA-Binding Proteins - physiology Gene expression Genetic aspects Genetic transcription Health aspects Human Genetics Humans Internal Medicine MADS Domain Proteins - deficiency MADS Domain Proteins - physiology Medicine Medicine & Public Health MEF2 Transcription Factors Mice Mice, Knockout Multiprotein Complexes Muscular Diseases - genetics Muscular Diseases - pathology Myogenic Regulatory Factors - physiology Notch protein Oncology Organ Specificity p53 Protein Protein Interaction Mapping Proteins Receptors, Notch - chemistry Receptors, Notch - physiology review Signal transduction Signal Transduction - physiology Trans-Activators - chemistry Trans-Activators - physiology Transcription activation Transcription Factors Transcriptional Activation - physiology Tumor suppressor genes Tumor Suppressor Protein p53 - physiology Tumor Suppressor Proteins - physiology Tumors β-Catenin
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