Polyvalency: A promising strategy for drug design

The simultaneous binding of multiple ligands on one entity to multiple receptors on another can result in an affinity that is significantly greater than that for the binding of a single ligand to a single receptor. This concept of "polyvalency" can be used to design molecules that are pote...

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Veröffentlicht in:	Biotechnology and bioengineering 2008-10, Vol.101 (3), p.429-434
Hauptverfasser:	Vance, David, Shah, Mrinal, Joshi, Amit, Kane, Ravi S
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthrax anthrax toxin Antigens, Bacterial - chemistry Bacterial Toxins - antagonists & inhibitors Bacterial Toxins - chemistry Biological and medical sciences Biotechnology Chemical bonds Drug Design Drugs Fundamental and applied biological sciences. Psychology inhibitors ligands liposomes Models, Biological peptides Pharmacology Polymers polyvalency Receptors, Cell Surface - chemistry Receptors, Cell Surface - metabolism Structure-Activity Relationship Toxins
Online-Zugang:	Volltext
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