An Improved Asymmetric Synthesis of Malyngamide U and Its 2′-Epimer

An accelerated and improved asymmetric synthesis of malyngamide U (1) and its 2′-epimer (2′-epi-1) was accomplished from readily available n-hexanal, ethanolamine and (R)-(−)-carvone. The key steps involved a Johnson−Claisen rearrangement in the synthesis of an unsaturated carboxylic acid 4 and an a...

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Veröffentlicht in:	Journal of organic chemistry 2008-09, Vol.73 (17), p.6873-6876
Hauptverfasser:	Feng, Jian-Peng, Shi, Zi-Fa, Li, Yang, Zhang, Jun-Tao, Qi, Xian-Liang, Chen, Jie, Cao, Xiao-Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohols - chemistry Aldehydes - chemistry Alicyclic compounds Alicyclic compounds, terpenoids, prostaglandins, steroids Carboxylic Acids - chemistry Chemistry Cyclohexanones - chemical synthesis Ethanolamine - chemistry Exact sciences and technology Fatty Acids, Monounsaturated - chemical synthesis Models, Chemical Monoterpenes - chemistry Organic chemistry Preparations and properties
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