CD4 memory T cells on trial: immunological memory without a memory T cell
Immunological memory crucially depends on CD4 T cells. In contrast with B cells, we find no decisive evidence that CD4 T cells are permanently altered by antigen stimulation. We propose that the memory response is derived from an increase in frequency of resting naïve-like CD4 T cells with a half-li...
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| Veröffentlicht in: | Immunology today (Amsterdam. Regular ed.) 2008-09, Vol.29 (9), p.405-411 |
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| container_title | Immunology today (Amsterdam. Regular ed.) |
| container_volume | 29 |
| creator | Bell, Eric B Westermann, Jürgen |
| description | Immunological memory crucially depends on CD4 T cells. In contrast with B cells, we find no decisive evidence that CD4 T cells are permanently altered by antigen stimulation. We propose that the memory response is derived from an increase in frequency of resting naïve-like CD4 T cells with a half-life of years (or months in rodents), rather than the currently proposed specialized T-cell types that have a known lifespan of days. In addition, residual antigen will significantly influence the longevity of a memory response. Our model offers a new insight into immunological memory that could assist the development of CD4 T cell–based vaccines. |
| doi_str_mv | 10.1016/j.it.2008.06.002 |
| format | Article |
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| ispartof | Immunology today (Amsterdam. Regular ed.), 2008-09, Vol.29 (9), p.405-411 |
| issn | 1471-4906 0167-5699 1471-4981 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Collection |
| subjects | Allergy and Immunology Animals Antibody Formation - immunology Antigens Antigens - immunology CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cell Differentiation - immunology Cell Survival - immunology Cytokines Genotype & phenotype Humans Immunity, Cellular - immunology Immunologic Memory - immunology Lymphocytes Mice Models, Immunological Molecular weight Pragmatism T cell receptors T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Tuberculosis Vaccines Vaccines - immunology |
| title | CD4 memory T cells on trial: immunological memory without a memory T cell |
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