CEACAM3: An innate immune receptor directed against human-restricted bacterial pathogens
Abstract Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) is an immunoglobulin-related glycoprotein exclusively expressed on granulocytes. In contrast to other members of the CEACAM family, CEACAM3 does not support cell–cell adhesion, but rather mediates the opsonin-independent re...
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| Veröffentlicht in: | International journal of medical microbiology 2008-10, Vol.298 (7), p.553-560 |
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| creator | Pils, Stefan Gerrard, Dave T Meyer, Axel Hauck, Christof R |
| description | Abstract Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) is an immunoglobulin-related glycoprotein exclusively expressed on granulocytes. In contrast to other members of the CEACAM family, CEACAM3 does not support cell–cell adhesion, but rather mediates the opsonin-independent recognition and elimination of a restricted set of human-specific Gram-negative bacterial pathogens including Neisseria gonorrhoeae , Haemophilus influenzae , and Moraxella catarrhalis . Within the last 4 years, molecular determinants of CEACAM3 function and CEACAM3-initiated signaling pathways have been elucidated. Sequence comparison between CEACAM3 and other CEACAM family members points to a chimeric origin of this receptor with the bacteria-binding extracellular domain and the function-promoting intracellular domain derived from different genes. This review summarizes the current knowledge about the structure–function relationship of CEACAM3 and tries to combine these molecular aspects with a plausible scenario concerning the evolutionary origin of this phagocyte receptor in the light of host–pathogen adaptation. |
| doi_str_mv | 10.1016/j.ijmm.2008.04.005 |
| format | Article |
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In contrast to other members of the CEACAM family, CEACAM3 does not support cell–cell adhesion, but rather mediates the opsonin-independent recognition and elimination of a restricted set of human-specific Gram-negative bacterial pathogens including Neisseria gonorrhoeae , Haemophilus influenzae , and Moraxella catarrhalis . Within the last 4 years, molecular determinants of CEACAM3 function and CEACAM3-initiated signaling pathways have been elucidated. Sequence comparison between CEACAM3 and other CEACAM family members points to a chimeric origin of this receptor with the bacteria-binding extracellular domain and the function-promoting intracellular domain derived from different genes. This review summarizes the current knowledge about the structure–function relationship of CEACAM3 and tries to combine these molecular aspects with a plausible scenario concerning the evolutionary origin of this phagocyte receptor in the light of host–pathogen adaptation.</description><identifier>ISSN: 1438-4221</identifier><identifier>EISSN: 1618-0607</identifier><identifier>DOI: 10.1016/j.ijmm.2008.04.005</identifier><identifier>PMID: 18606569</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Bacteria ; Carcinoembryonic Antigen - chemistry ; Carcinoembryonic Antigen - genetics ; Carcinoembryonic Antigen - immunology ; Evolution, Molecular ; Gram-Negative Bacteria - immunology ; Haemophilus influenzae ; Host–pathogen coevolution ; Humans ; Infectious Disease ; ITAM ; Medical Education ; Moraxella catarrhalis ; Neisseria gonorrhoeae ; Phagocytosis ; Signal Transduction</subject><ispartof>International journal of medical microbiology, 2008-10, Vol.298 (7), p.553-560</ispartof><rights>2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-c54198ad2de05536a380e555e5fb9a5d3f5c2b70eba56a0908a76edba2cc753e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijmm.2008.04.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18606569$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pils, Stefan</creatorcontrib><creatorcontrib>Gerrard, Dave T</creatorcontrib><creatorcontrib>Meyer, Axel</creatorcontrib><creatorcontrib>Hauck, Christof R</creatorcontrib><title>CEACAM3: An innate immune receptor directed against human-restricted bacterial pathogens</title><title>International journal of medical microbiology</title><addtitle>Int J Med Microbiol</addtitle><description>Abstract Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) is an immunoglobulin-related glycoprotein exclusively expressed on granulocytes. In contrast to other members of the CEACAM family, CEACAM3 does not support cell–cell adhesion, but rather mediates the opsonin-independent recognition and elimination of a restricted set of human-specific Gram-negative bacterial pathogens including Neisseria gonorrhoeae , Haemophilus influenzae , and Moraxella catarrhalis . Within the last 4 years, molecular determinants of CEACAM3 function and CEACAM3-initiated signaling pathways have been elucidated. Sequence comparison between CEACAM3 and other CEACAM family members points to a chimeric origin of this receptor with the bacteria-binding extracellular domain and the function-promoting intracellular domain derived from different genes. This review summarizes the current knowledge about the structure–function relationship of CEACAM3 and tries to combine these molecular aspects with a plausible scenario concerning the evolutionary origin of this phagocyte receptor in the light of host–pathogen adaptation.</description><subject>Bacteria</subject><subject>Carcinoembryonic Antigen - chemistry</subject><subject>Carcinoembryonic Antigen - genetics</subject><subject>Carcinoembryonic Antigen - immunology</subject><subject>Evolution, Molecular</subject><subject>Gram-Negative Bacteria - immunology</subject><subject>Haemophilus influenzae</subject><subject>Host–pathogen coevolution</subject><subject>Humans</subject><subject>Infectious Disease</subject><subject>ITAM</subject><subject>Medical Education</subject><subject>Moraxella catarrhalis</subject><subject>Neisseria gonorrhoeae</subject><subject>Phagocytosis</subject><subject>Signal Transduction</subject><issn>1438-4221</issn><issn>1618-0607</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9r1UAUxQdRbK1-AReSlbukd_5mIiI8Hq0tVFyo4G6YTO5rJyaT50xS6LfvxPdAcFFX98I953D5HULeUqgoUHXeV74fx4oB6ApEBSCfkVOqqC5BQf0874LrUjBGT8irlHoAYA1XL8kJ1QqUVM0p-bm92Gw3X_iHYhMKH4KdsfDjuAQsIjrcz1MsOp_XGbvC3lof0lzcLaMNZcQ0R__n0No8ordDsbfz3XSLIb0mL3Z2SPjmOM_Ij8uL79ur8ubr5-vt5qZ0Qou5dFLQRtuOdQhScmW5BpRSoty1jZUd30nH2hqwtVJZaEDbWmHXWuZcLTnyM_L-kLuP0-8lv2RGnxwOgw04LcmoRmgllPqvMGMUEqTIQnYQujilFHFn9tGPNj4YCmYFb3qzgl8d2oAwGXw2vTumL-2I3V_LkXQWfDwIMMO49xhNch6DwwNd003-6fxP_9jd4IN3dviFD5j6aYkhYzbUJGbAfFurX5sHnVtXouaPj5-pQg</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Pils, Stefan</creator><creator>Gerrard, Dave T</creator><creator>Meyer, Axel</creator><creator>Hauck, Christof R</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20081001</creationdate><title>CEACAM3: An innate immune receptor directed against human-restricted bacterial pathogens</title><author>Pils, Stefan ; Gerrard, Dave T ; Meyer, Axel ; Hauck, Christof R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-c54198ad2de05536a380e555e5fb9a5d3f5c2b70eba56a0908a76edba2cc753e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Bacteria</topic><topic>Carcinoembryonic Antigen - chemistry</topic><topic>Carcinoembryonic Antigen - genetics</topic><topic>Carcinoembryonic Antigen - immunology</topic><topic>Evolution, Molecular</topic><topic>Gram-Negative Bacteria - immunology</topic><topic>Haemophilus influenzae</topic><topic>Host–pathogen coevolution</topic><topic>Humans</topic><topic>Infectious Disease</topic><topic>ITAM</topic><topic>Medical Education</topic><topic>Moraxella catarrhalis</topic><topic>Neisseria gonorrhoeae</topic><topic>Phagocytosis</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pils, Stefan</creatorcontrib><creatorcontrib>Gerrard, Dave T</creatorcontrib><creatorcontrib>Meyer, Axel</creatorcontrib><creatorcontrib>Hauck, Christof R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of medical microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pils, Stefan</au><au>Gerrard, Dave T</au><au>Meyer, Axel</au><au>Hauck, Christof R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CEACAM3: An innate immune receptor directed against human-restricted bacterial pathogens</atitle><jtitle>International journal of medical microbiology</jtitle><addtitle>Int J Med Microbiol</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>298</volume><issue>7</issue><spage>553</spage><epage>560</epage><pages>553-560</pages><issn>1438-4221</issn><eissn>1618-0607</eissn><abstract>Abstract Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) is an immunoglobulin-related glycoprotein exclusively expressed on granulocytes. 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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Bacteria Carcinoembryonic Antigen - chemistry Carcinoembryonic Antigen - genetics Carcinoembryonic Antigen - immunology Evolution, Molecular Gram-Negative Bacteria - immunology Haemophilus influenzae Host–pathogen coevolution Humans Infectious Disease ITAM Medical Education Moraxella catarrhalis Neisseria gonorrhoeae Phagocytosis Signal Transduction |
| title | CEACAM3: An innate immune receptor directed against human-restricted bacterial pathogens |
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