Determination of the minimum inhibitory concentration of fluconazole against Cryptococcus neoformans
The minimum inhibitory concentration of fluconozole was determined in 36 strains of Cryptococcus neoformans var. neoformans by a casitone broth microdilution method, taking into account that it is one of the most used antifungal agents in our country for the treatment of cryptococcal meningitis, the...
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| Veröffentlicht in: | Revista cubana de medicina tropical 1999-01, Vol.51 (1), p.55-57 |
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| container_title | Revista cubana de medicina tropical |
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| creator | Fernández Andreu, C M Pimentel Turino, T Martínez Machín, G González Miranda, M |
| description | The minimum inhibitory concentration of fluconozole was determined in 36 strains of Cryptococcus neoformans var. neoformans by a casitone broth microdilution method, taking into account that it is one of the most used antifungal agents in our country for the treatment of cryptococcal meningitis, the second opportunistic mycosis in order of frequency and that with the highest lethality among AIDS patients. The minimum inhibitory concentration of the studied strains ranged 0.125 to more than 64 micrograms/mL for a geometrical mean of 2.38 micrograms/mL. 50% of the strains were inhibited with 4 micrograms/mL and the least concentration that inhibited 90% was 16 micrograms/mL. It is stressed the importance of continuing this type of in vitro studies to detect the appearance of resistance of C. neoformans to antifungal agents. |
| format | Article |
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The minimum inhibitory concentration of the studied strains ranged 0.125 to more than 64 micrograms/mL for a geometrical mean of 2.38 micrograms/mL. 50% of the strains were inhibited with 4 micrograms/mL and the least concentration that inhibited 90% was 16 micrograms/mL. 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The minimum inhibitory concentration of the studied strains ranged 0.125 to more than 64 micrograms/mL for a geometrical mean of 2.38 micrograms/mL. 50% of the strains were inhibited with 4 micrograms/mL and the least concentration that inhibited 90% was 16 micrograms/mL. 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| source | MEDLINE; Free E-Journal (出版社公開部分のみ） |
| subjects | AIDS/HIV Antifungal Agents - pharmacology Cryptococcus neoformans - drug effects Fluconazole - pharmacology Humans Microbial Sensitivity Tests |
| title | Determination of the minimum inhibitory concentration of fluconazole against Cryptococcus neoformans |
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