Potential artefacts in proteome analysis of plasma of Gaucher patients due to protease abnormalities

The plasma proteome of type I Gaucher disease patients was investigated by 2D gel electrophoresis (2DGE). Using the classical procedure with 8 M urea treated plasma, several high molecular weight proteins were absent from Gaucher plasma specimens, while additional low molecular weight proteins were...

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Veröffentlicht in:	Clinica chimica acta 2008-10, Vol.396 (1), p.26-32
Hauptverfasser:	van Breemen, Mariëlle J., Aerts, Johannes M.F.G., Sprenger, Richard R., Speijer, Dave
Format:	Artikel
Sprache:	eng
Schlagworte:	2D gel electrophoresis Benzamides Cathepsins Electrophoresis, Gel, Two-Dimensional Endopeptidases - blood Endopeptidases - metabolism Gaucher disease Gaucher Disease - blood Gaucher Disease - enzymology Humans Plasma Protease Proteolysis Proteome - analysis Proteome - metabolism Sepharose - analogs & derivatives Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Thiourea
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