p53 and MDM2 expression in odontogenic cysts and tumours
OBJECTIVE: The aim of this report was to assess p53 and MDM2 expression in odontogenic cysts and tumours, as they are known to play important roles in cell proliferation and tumorigenesis. MATERIALS AND METHODS: The expression of p53 and MDM2 proteins was determined immunohistochemically in 51 forma...
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| Veröffentlicht in: | Oral diseases 1999-07, Vol.5 (3), p.218-222 |
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| creator | Carvalhais, JN de Aguiar, MCF de Araújo, VC de Araújo, NS Gomez, RS |
| description | OBJECTIVE: The aim of this report was to assess p53 and MDM2 expression in odontogenic cysts and tumours, as they are known to play important roles in cell proliferation and tumorigenesis.
MATERIALS AND METHODS: The expression of p53 and MDM2 proteins was determined immunohistochemically in 51 formalin‐fixed, paraffin embedded specimens of odontogenic cysts and tumours.
RESULTS: No positivity to p53 was found in the cases studied. MDM2 expression in ameloblastoma was higher than in radicular cysts, but lower than that observed in odontogenic keratocysts. No difference was observed between MDM2 expression in radicular cyst and adenomatoid odontogenic tumour. The clear‐cell odontogenic ameloblastoma presented strong immunoreaction to this antigen.
CONCLUSIONS: The results suggest that MDM2 over‐expression may be involved in the pathogenesis of some odontogenic lesions. |
| doi_str_mv | 10.1111/j.1601-0825.1999.tb00304.x |
| format | Article |
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MATERIALS AND METHODS: The expression of p53 and MDM2 proteins was determined immunohistochemically in 51 formalin‐fixed, paraffin embedded specimens of odontogenic cysts and tumours.
RESULTS: No positivity to p53 was found in the cases studied. MDM2 expression in ameloblastoma was higher than in radicular cysts, but lower than that observed in odontogenic keratocysts. No difference was observed between MDM2 expression in radicular cyst and adenomatoid odontogenic tumour. The clear‐cell odontogenic ameloblastoma presented strong immunoreaction to this antigen.
CONCLUSIONS: The results suggest that MDM2 over‐expression may be involved in the pathogenesis of some odontogenic lesions.</description><identifier>ISSN: 1354-523X</identifier><identifier>EISSN: 1601-0825</identifier><identifier>DOI: 10.1111/j.1601-0825.1999.tb00304.x</identifier><identifier>PMID: 10483067</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Biological and medical sciences ; Dentistry ; Ent. Stomatology ; Facial bones, jaws, teeth, parodontium: diseases, semeiology ; Gene Expression ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Investigative techniques, diagnostic techniques (general aspects) ; MDM2 ; Medical sciences ; Neoplasm Proteins - metabolism ; Nuclear Proteins ; odontogenic cysts ; Odontogenic Cysts - genetics ; Odontogenic Cysts - metabolism ; Odontogenic Tumors - genetics ; Odontogenic Tumors - metabolism ; odontogenic tumours ; Otorhinolaryngology. Stomatology ; p53 ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Proto-Oncogene Proteins - metabolism ; Proto-Oncogene Proteins c-mdm2 ; Tumor Suppressor Protein p53 - metabolism ; Tumors ; Up-Regulation</subject><ispartof>Oral diseases, 1999-07, Vol.5 (3), p.218-222</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4378-e022ad44b5583f49ff37a73d6ba751cf4c7f604ecf8f20d2d98881a5cc9fe1353</citedby><cites>FETCH-LOGICAL-c4378-e022ad44b5583f49ff37a73d6ba751cf4c7f604ecf8f20d2d98881a5cc9fe1353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1601-0825.1999.tb00304.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1601-0825.1999.tb00304.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,1411,23909,23910,25118,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1921157$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10483067$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carvalhais, JN</creatorcontrib><creatorcontrib>de Aguiar, MCF</creatorcontrib><creatorcontrib>de Araújo, VC</creatorcontrib><creatorcontrib>de Araújo, NS</creatorcontrib><creatorcontrib>Gomez, RS</creatorcontrib><title>p53 and MDM2 expression in odontogenic cysts and tumours</title><title>Oral diseases</title><addtitle>Oral Dis</addtitle><description>OBJECTIVE: The aim of this report was to assess p53 and MDM2 expression in odontogenic cysts and tumours, as they are known to play important roles in cell proliferation and tumorigenesis.
MATERIALS AND METHODS: The expression of p53 and MDM2 proteins was determined immunohistochemically in 51 formalin‐fixed, paraffin embedded specimens of odontogenic cysts and tumours.
RESULTS: No positivity to p53 was found in the cases studied. MDM2 expression in ameloblastoma was higher than in radicular cysts, but lower than that observed in odontogenic keratocysts. No difference was observed between MDM2 expression in radicular cyst and adenomatoid odontogenic tumour. The clear‐cell odontogenic ameloblastoma presented strong immunoreaction to this antigen.
CONCLUSIONS: The results suggest that MDM2 over‐expression may be involved in the pathogenesis of some odontogenic lesions.</description><subject>Biological and medical sciences</subject><subject>Dentistry</subject><subject>Ent. Stomatology</subject><subject>Facial bones, jaws, teeth, parodontium: diseases, semeiology</subject><subject>Gene Expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>MDM2</subject><subject>Medical sciences</subject><subject>Neoplasm Proteins - metabolism</subject><subject>Nuclear Proteins</subject><subject>odontogenic cysts</subject><subject>Odontogenic Cysts - genetics</subject><subject>Odontogenic Cysts - metabolism</subject><subject>Odontogenic Tumors - genetics</subject><subject>Odontogenic Tumors - metabolism</subject><subject>odontogenic tumours</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>p53</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Proto-Oncogene Proteins c-mdm2</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><subject>Tumors</subject><subject>Up-Regulation</subject><issn>1354-523X</issn><issn>1601-0825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkFtLwzAYhoMoztNfkCLiXWuOTeKFIJs6wQOIst2FLE2ks2tn0uL2723tUG_NTQJ5vvd7eQA4QTBB7TmfJyiFKIYCswRJKZN6BiGBNFltgb2fr-32TRiNGSbTAdgPYQ4h4pLgXTBAkAoCU74HxJKRSJdZ9DB6wJFdLb0NIa_KKC-jKqvKunqzZW4isw51-AbrZlE1PhyCHaeLYI829wF4vbl-GY7j-6fbu-HVfWwo4SK2EGOdUTpjTBBHpXOEa06ydKY5Q8ZRw10KqTVOOAwznEkhBNLMGOls258cgLM-d-mrj8aGWi3yYGxR6NJWTVCppIIKzlvwogeNr0Lw1qmlzxfarxWCqvOm5qqTozo5qvOmNt7Uqh0-3mxpZgub_RntRbXA6QbQwejCeV2aPPxyEiPEOuyyxz7zwq7_0UA9je4wEm1A3AfkobarnwDt31XbgjM1ebxVz-Pp5GY0HCpCvgDqkZgh</recordid><startdate>19990701</startdate><enddate>19990701</enddate><creator>Carvalhais, JN</creator><creator>de Aguiar, MCF</creator><creator>de Araújo, VC</creator><creator>de Araújo, NS</creator><creator>Gomez, RS</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990701</creationdate><title>p53 and MDM2 expression in odontogenic cysts and tumours</title><author>Carvalhais, JN ; de Aguiar, MCF ; de Araújo, VC ; de Araújo, NS ; Gomez, RS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4378-e022ad44b5583f49ff37a73d6ba751cf4c7f604ecf8f20d2d98881a5cc9fe1353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Biological and medical sciences</topic><topic>Dentistry</topic><topic>Ent. Stomatology</topic><topic>Facial bones, jaws, teeth, parodontium: diseases, semeiology</topic><topic>Gene Expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>MDM2</topic><topic>Medical sciences</topic><topic>Neoplasm Proteins - metabolism</topic><topic>Nuclear Proteins</topic><topic>odontogenic cysts</topic><topic>Odontogenic Cysts - genetics</topic><topic>Odontogenic Cysts - metabolism</topic><topic>Odontogenic Tumors - genetics</topic><topic>Odontogenic Tumors - metabolism</topic><topic>odontogenic tumours</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>p53</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Proto-Oncogene Proteins - metabolism</topic><topic>Proto-Oncogene Proteins c-mdm2</topic><topic>Tumor Suppressor Protein p53 - metabolism</topic><topic>Tumors</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carvalhais, JN</creatorcontrib><creatorcontrib>de Aguiar, MCF</creatorcontrib><creatorcontrib>de Araújo, VC</creatorcontrib><creatorcontrib>de Araújo, NS</creatorcontrib><creatorcontrib>Gomez, RS</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Oral diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carvalhais, JN</au><au>de Aguiar, MCF</au><au>de Araújo, VC</au><au>de Araújo, NS</au><au>Gomez, RS</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>p53 and MDM2 expression in odontogenic cysts and tumours</atitle><jtitle>Oral diseases</jtitle><addtitle>Oral Dis</addtitle><date>1999-07-01</date><risdate>1999</risdate><volume>5</volume><issue>3</issue><spage>218</spage><epage>222</epage><pages>218-222</pages><issn>1354-523X</issn><eissn>1601-0825</eissn><abstract>OBJECTIVE: The aim of this report was to assess p53 and MDM2 expression in odontogenic cysts and tumours, as they are known to play important roles in cell proliferation and tumorigenesis.
MATERIALS AND METHODS: The expression of p53 and MDM2 proteins was determined immunohistochemically in 51 formalin‐fixed, paraffin embedded specimens of odontogenic cysts and tumours.
RESULTS: No positivity to p53 was found in the cases studied. MDM2 expression in ameloblastoma was higher than in radicular cysts, but lower than that observed in odontogenic keratocysts. No difference was observed between MDM2 expression in radicular cyst and adenomatoid odontogenic tumour. The clear‐cell odontogenic ameloblastoma presented strong immunoreaction to this antigen.
CONCLUSIONS: The results suggest that MDM2 over‐expression may be involved in the pathogenesis of some odontogenic lesions.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>10483067</pmid><doi>10.1111/j.1601-0825.1999.tb00304.x</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Biological and medical sciences Dentistry Ent. Stomatology Facial bones, jaws, teeth, parodontium: diseases, semeiology Gene Expression Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) MDM2 Medical sciences Neoplasm Proteins - metabolism Nuclear Proteins odontogenic cysts Odontogenic Cysts - genetics Odontogenic Cysts - metabolism Odontogenic Tumors - genetics Odontogenic Tumors - metabolism odontogenic tumours Otorhinolaryngology. Stomatology p53 Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-mdm2 Tumor Suppressor Protein p53 - metabolism Tumors Up-Regulation |
| title | p53 and MDM2 expression in odontogenic cysts and tumours |
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