Integrating the QCM detection with magnetic separation for on-line analysis
We investigate the feasibility of coupling the quartz crystal microbalance (QCM) with magnetic separation for on-line analysis. A flow cell was integrated with QCM and magnetic force for the analysis of magnetic and nonmagnetic samples. The resonant frequency change (Δ f) of QCM was related to the a...
Gespeichert in:
| Veröffentlicht in: | Biosensors & bioelectronics 2008-11, Vol.24 (3), p.485-488 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 488 |
|---|---|
| container_issue | 3 |
| container_start_page | 485 |
| container_title | Biosensors & bioelectronics |
| container_volume | 24 |
| creator | Tsai, Hweiyan Lin, Yi Chang, Hung W. Fuh, C. Bor |
| description | We investigate the feasibility of coupling the quartz crystal microbalance (QCM) with magnetic separation for on-line analysis.
A flow cell was integrated with QCM and magnetic force for the analysis of magnetic and nonmagnetic samples. The resonant frequency change (Δ
f) of QCM was related to the amount of deposited magnetic nanoparticles. This experiment demonstrates that QCM can be used as an on-line detector for magnetic separation.
The QCM also gives a characteristic response of the binding between the streptavidin and biotin labeled on the magnetic nanoparticles. Biotin-labeled magnetic nanoparticles were flowed through a gold electrode of QCM to deposit as a matrix for selective capturing streptavidin. The resonant frequency change of QCM was proportional to the amounts of streptavidin captured by biotin. This technique can provide a simple, economic, and automatic method for on-line detection of biomarkers. |
| doi_str_mv | 10.1016/j.bios.2008.06.015 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69484678</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0956566308002674</els_id><sourcerecordid>69484678</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-cababf9afb48bf37bedf41a434d9fee7a93f71a2e24bc4f08645e73143a2007c3</originalsourceid><addsrcrecordid>eNqFkU2P0zAQhi0EYruFP8AB5QK3hHHsxInEBVXsh3YRQoKzNXHGXVepU2yX1f57HLWCG5zmMM-8mnmGsTccKg68_bCrBjfHqgboKmgr4M0ztuKdEqWsRfOcraBv2rJpW3HBLmPcAYDiPbxkF7xrJUAtVuzu1ifaBkzOb4v0QMW3zZdipEQmudkXjy49FHvcekrOFJEOuKC5YedQzL6cnKcCPU5P0cVX7IXFKdLrc12zH1efv29uyvuv17ebT_elkbxJpcEBB9ujHWQ3WKEGGq3kKIUce0uksBdWcayploORFvKuDSnBpcB8qjJizd6fcg9h_nmkmPTeRUPThJ7mY9RtLzvZqu6_YA097xY_a1afQBPmGANZfQhuj-FJc9CLa73Ti2u9uNbQ6uw6D709px-HPY1_R85yM_DuDGA0ONmA3rj4h6s570D1PHMfTxxlab8cBR2NI29odCH_QY-z-9cevwG2XZ2I</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20918566</pqid></control><display><type>article</type><title>Integrating the QCM detection with magnetic separation for on-line analysis</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Tsai, Hweiyan ; Lin, Yi ; Chang, Hung W. ; Fuh, C. Bor</creator><creatorcontrib>Tsai, Hweiyan ; Lin, Yi ; Chang, Hung W. ; Fuh, C. Bor</creatorcontrib><description>We investigate the feasibility of coupling the quartz crystal microbalance (QCM) with magnetic separation for on-line analysis.
A flow cell was integrated with QCM and magnetic force for the analysis of magnetic and nonmagnetic samples. The resonant frequency change (Δ
f) of QCM was related to the amount of deposited magnetic nanoparticles. This experiment demonstrates that QCM can be used as an on-line detector for magnetic separation.
The QCM also gives a characteristic response of the binding between the streptavidin and biotin labeled on the magnetic nanoparticles. Biotin-labeled magnetic nanoparticles were flowed through a gold electrode of QCM to deposit as a matrix for selective capturing streptavidin. The resonant frequency change of QCM was proportional to the amounts of streptavidin captured by biotin. This technique can provide a simple, economic, and automatic method for on-line detection of biomarkers.</description><identifier>ISSN: 0956-5663</identifier><identifier>EISSN: 1873-4235</identifier><identifier>DOI: 10.1016/j.bios.2008.06.015</identifier><identifier>PMID: 18640023</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Biological and medical sciences ; Biosensing Techniques - methods ; Biotechnology ; Biotin - chemistry ; Fundamental and applied biological sciences. Psychology ; Immunomagnetic assays ; Immunomagnetic Separation - methods ; Magnetic separation ; Nanoparticles ; Quartz - chemistry ; Quartz crystal microbalance (QCM) ; Streptavidin - chemistry</subject><ispartof>Biosensors & bioelectronics, 2008-11, Vol.24 (3), p.485-488</ispartof><rights>2008 Elsevier B.V.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-cababf9afb48bf37bedf41a434d9fee7a93f71a2e24bc4f08645e73143a2007c3</citedby><cites>FETCH-LOGICAL-c415t-cababf9afb48bf37bedf41a434d9fee7a93f71a2e24bc4f08645e73143a2007c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bios.2008.06.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21180791$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18640023$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsai, Hweiyan</creatorcontrib><creatorcontrib>Lin, Yi</creatorcontrib><creatorcontrib>Chang, Hung W.</creatorcontrib><creatorcontrib>Fuh, C. Bor</creatorcontrib><title>Integrating the QCM detection with magnetic separation for on-line analysis</title><title>Biosensors & bioelectronics</title><addtitle>Biosens Bioelectron</addtitle><description>We investigate the feasibility of coupling the quartz crystal microbalance (QCM) with magnetic separation for on-line analysis.
A flow cell was integrated with QCM and magnetic force for the analysis of magnetic and nonmagnetic samples. The resonant frequency change (Δ
f) of QCM was related to the amount of deposited magnetic nanoparticles. This experiment demonstrates that QCM can be used as an on-line detector for magnetic separation.
The QCM also gives a characteristic response of the binding between the streptavidin and biotin labeled on the magnetic nanoparticles. Biotin-labeled magnetic nanoparticles were flowed through a gold electrode of QCM to deposit as a matrix for selective capturing streptavidin. The resonant frequency change of QCM was proportional to the amounts of streptavidin captured by biotin. This technique can provide a simple, economic, and automatic method for on-line detection of biomarkers.</description><subject>Biological and medical sciences</subject><subject>Biosensing Techniques - methods</subject><subject>Biotechnology</subject><subject>Biotin - chemistry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunomagnetic assays</subject><subject>Immunomagnetic Separation - methods</subject><subject>Magnetic separation</subject><subject>Nanoparticles</subject><subject>Quartz - chemistry</subject><subject>Quartz crystal microbalance (QCM)</subject><subject>Streptavidin - chemistry</subject><issn>0956-5663</issn><issn>1873-4235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2P0zAQhi0EYruFP8AB5QK3hHHsxInEBVXsh3YRQoKzNXHGXVepU2yX1f57HLWCG5zmMM-8mnmGsTccKg68_bCrBjfHqgboKmgr4M0ztuKdEqWsRfOcraBv2rJpW3HBLmPcAYDiPbxkF7xrJUAtVuzu1ifaBkzOb4v0QMW3zZdipEQmudkXjy49FHvcekrOFJEOuKC5YedQzL6cnKcCPU5P0cVX7IXFKdLrc12zH1efv29uyvuv17ebT_elkbxJpcEBB9ujHWQ3WKEGGq3kKIUce0uksBdWcayploORFvKuDSnBpcB8qjJizd6fcg9h_nmkmPTeRUPThJ7mY9RtLzvZqu6_YA097xY_a1afQBPmGANZfQhuj-FJc9CLa73Ti2u9uNbQ6uw6D709px-HPY1_R85yM_DuDGA0ONmA3rj4h6s570D1PHMfTxxlab8cBR2NI29odCH_QY-z-9cevwG2XZ2I</recordid><startdate>20081115</startdate><enddate>20081115</enddate><creator>Tsai, Hweiyan</creator><creator>Lin, Yi</creator><creator>Chang, Hung W.</creator><creator>Fuh, C. Bor</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20081115</creationdate><title>Integrating the QCM detection with magnetic separation for on-line analysis</title><author>Tsai, Hweiyan ; Lin, Yi ; Chang, Hung W. ; Fuh, C. Bor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-cababf9afb48bf37bedf41a434d9fee7a93f71a2e24bc4f08645e73143a2007c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biological and medical sciences</topic><topic>Biosensing Techniques - methods</topic><topic>Biotechnology</topic><topic>Biotin - chemistry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Immunomagnetic assays</topic><topic>Immunomagnetic Separation - methods</topic><topic>Magnetic separation</topic><topic>Nanoparticles</topic><topic>Quartz - chemistry</topic><topic>Quartz crystal microbalance (QCM)</topic><topic>Streptavidin - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsai, Hweiyan</creatorcontrib><creatorcontrib>Lin, Yi</creatorcontrib><creatorcontrib>Chang, Hung W.</creatorcontrib><creatorcontrib>Fuh, C. Bor</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biosensors & bioelectronics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsai, Hweiyan</au><au>Lin, Yi</au><au>Chang, Hung W.</au><au>Fuh, C. Bor</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Integrating the QCM detection with magnetic separation for on-line analysis</atitle><jtitle>Biosensors & bioelectronics</jtitle><addtitle>Biosens Bioelectron</addtitle><date>2008-11-15</date><risdate>2008</risdate><volume>24</volume><issue>3</issue><spage>485</spage><epage>488</epage><pages>485-488</pages><issn>0956-5663</issn><eissn>1873-4235</eissn><abstract>We investigate the feasibility of coupling the quartz crystal microbalance (QCM) with magnetic separation for on-line analysis.
A flow cell was integrated with QCM and magnetic force for the analysis of magnetic and nonmagnetic samples. The resonant frequency change (Δ
f) of QCM was related to the amount of deposited magnetic nanoparticles. This experiment demonstrates that QCM can be used as an on-line detector for magnetic separation.
The QCM also gives a characteristic response of the binding between the streptavidin and biotin labeled on the magnetic nanoparticles. Biotin-labeled magnetic nanoparticles were flowed through a gold electrode of QCM to deposit as a matrix for selective capturing streptavidin. The resonant frequency change of QCM was proportional to the amounts of streptavidin captured by biotin. This technique can provide a simple, economic, and automatic method for on-line detection of biomarkers.</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><pmid>18640023</pmid><doi>10.1016/j.bios.2008.06.015</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0956-5663 |
| ispartof | Biosensors & bioelectronics, 2008-11, Vol.24 (3), p.485-488 |
| issn | 0956-5663 1873-4235 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69484678 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Biosensing Techniques - methods Biotechnology Biotin - chemistry Fundamental and applied biological sciences. Psychology Immunomagnetic assays Immunomagnetic Separation - methods Magnetic separation Nanoparticles Quartz - chemistry Quartz crystal microbalance (QCM) Streptavidin - chemistry |
| title | Integrating the QCM detection with magnetic separation for on-line analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T22%3A41%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Integrating%20the%20QCM%20detection%20with%20magnetic%20separation%20for%20on-line%20analysis&rft.jtitle=Biosensors%20&%20bioelectronics&rft.au=Tsai,%20Hweiyan&rft.date=2008-11-15&rft.volume=24&rft.issue=3&rft.spage=485&rft.epage=488&rft.pages=485-488&rft.issn=0956-5663&rft.eissn=1873-4235&rft_id=info:doi/10.1016/j.bios.2008.06.015&rft_dat=%3Cproquest_cross%3E69484678%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20918566&rft_id=info:pmid/18640023&rft_els_id=S0956566308002674&rfr_iscdi=true |