The lifestyle of Corynebacterium urealyticum derived from its complete genome sequence established by pyrosequencing
Corynebacterium urealyticum is a lipid-requiring, urealytic bacterium of the human skin flora that has been recognized as causative agent of urinary tract infections. We report the analysis of the complete genome sequence of C. urealyticum DSM7109, which was initially recovered from a patient with a...
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| creator | Tauch, Andreas Trost, Eva Tilker, Alexandra Ludewig, Ulrike Schneiker, Susanne Goesmann, Alexander Arnold, Walter Bekel, Thomas Brinkrolf, Karina Brune, Iris Götker, Susanne Kalinowski, Jörn Kamp, Paul-Bertram Lobo, Francisco Pereira Viehoever, Prisca Weisshaar, Bernd Soriano, Francisco Dröge, Marcus Pühler, Alfred |
| description | Corynebacterium urealyticum is a lipid-requiring, urealytic bacterium of the human skin flora that has been recognized as causative agent of urinary tract infections. We report the analysis of the complete genome sequence of
C. urealyticum DSM7109, which was initially recovered from a patient with alkaline-encrusted cystitis. The genome sequence was determined by a combination of pyrosequencing and Sanger technology. The chromosome of
C. urealyticum DSM7109 has a size of 2,369,219
bp and contains 2024 predicted coding sequences, of which 78% were considered as orthologous with genes in the
Corynebacterium jeikeium K411 genome. Metabolic analysis of the lipid-requiring phenotype revealed the absence of a fatty acid synthase gene and the presence of a β-oxidation pathway along with a large repertoire of auxillary genes for the degradation of exogenous fatty acids. A urease locus with the gene order
ureABCEFGD may play a pivotal role in virulence of
C. urealyticum by the alkalinization of human urine and the formation of struvite stones. Multidrug resistance of
C. urealyticum DSM7109 is mediated by transposable elements, conferring resistances to macrolides, lincosamides, ketolides, aminoglycosides, chloramphenicol, and tetracycline. The complete genome sequence of
C. urealyticum revealed a detailed picture of the lifestyle of this opportunistic human pathogen. |
| doi_str_mv | 10.1016/j.jbiotec.2008.02.009 |
| format | Article |
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C. urealyticum DSM7109, which was initially recovered from a patient with alkaline-encrusted cystitis. The genome sequence was determined by a combination of pyrosequencing and Sanger technology. The chromosome of
C. urealyticum DSM7109 has a size of 2,369,219
bp and contains 2024 predicted coding sequences, of which 78% were considered as orthologous with genes in the
Corynebacterium jeikeium K411 genome. Metabolic analysis of the lipid-requiring phenotype revealed the absence of a fatty acid synthase gene and the presence of a β-oxidation pathway along with a large repertoire of auxillary genes for the degradation of exogenous fatty acids. A urease locus with the gene order
ureABCEFGD may play a pivotal role in virulence of
C. urealyticum by the alkalinization of human urine and the formation of struvite stones. Multidrug resistance of
C. urealyticum DSM7109 is mediated by transposable elements, conferring resistances to macrolides, lincosamides, ketolides, aminoglycosides, chloramphenicol, and tetracycline. The complete genome sequence of
C. urealyticum revealed a detailed picture of the lifestyle of this opportunistic human pathogen.</description><identifier>ISSN: 0168-1656</identifier><identifier>EISSN: 1873-4863</identifier><identifier>DOI: 10.1016/j.jbiotec.2008.02.009</identifier><identifier>PMID: 18367281</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Antibiotic resistance ; Bacterial Proteins - genetics ; Base Sequence ; Chromosome Mapping - methods ; Corynebacterium - genetics ; Corynebacterium jeikeium ; Corynebacterium urealyticum ; Genome sequence ; Genome, Bacterial - genetics ; Molecular Sequence Data ; Open Reading Frames - genetics ; Sequence Analysis, DNA - methods ; Urinary tract infection ; Virulence factors ; β-Oxidation</subject><ispartof>Journal of biotechnology, 2008-08, Vol.136 (1), p.11-21</ispartof><rights>2008 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-984d9332258448e75aef844edd3e23d9ee0461fd8263c9ecc159dda918804a013</citedby><cites>FETCH-LOGICAL-c484t-984d9332258448e75aef844edd3e23d9ee0461fd8263c9ecc159dda918804a013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S016816560800062X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18367281$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tauch, Andreas</creatorcontrib><creatorcontrib>Trost, Eva</creatorcontrib><creatorcontrib>Tilker, Alexandra</creatorcontrib><creatorcontrib>Ludewig, Ulrike</creatorcontrib><creatorcontrib>Schneiker, Susanne</creatorcontrib><creatorcontrib>Goesmann, Alexander</creatorcontrib><creatorcontrib>Arnold, Walter</creatorcontrib><creatorcontrib>Bekel, Thomas</creatorcontrib><creatorcontrib>Brinkrolf, Karina</creatorcontrib><creatorcontrib>Brune, Iris</creatorcontrib><creatorcontrib>Götker, Susanne</creatorcontrib><creatorcontrib>Kalinowski, Jörn</creatorcontrib><creatorcontrib>Kamp, Paul-Bertram</creatorcontrib><creatorcontrib>Lobo, Francisco Pereira</creatorcontrib><creatorcontrib>Viehoever, Prisca</creatorcontrib><creatorcontrib>Weisshaar, Bernd</creatorcontrib><creatorcontrib>Soriano, Francisco</creatorcontrib><creatorcontrib>Dröge, Marcus</creatorcontrib><creatorcontrib>Pühler, Alfred</creatorcontrib><title>The lifestyle of Corynebacterium urealyticum derived from its complete genome sequence established by pyrosequencing</title><title>Journal of biotechnology</title><addtitle>J Biotechnol</addtitle><description>Corynebacterium urealyticum is a lipid-requiring, urealytic bacterium of the human skin flora that has been recognized as causative agent of urinary tract infections. We report the analysis of the complete genome sequence of
C. urealyticum DSM7109, which was initially recovered from a patient with alkaline-encrusted cystitis. The genome sequence was determined by a combination of pyrosequencing and Sanger technology. The chromosome of
C. urealyticum DSM7109 has a size of 2,369,219
bp and contains 2024 predicted coding sequences, of which 78% were considered as orthologous with genes in the
Corynebacterium jeikeium K411 genome. Metabolic analysis of the lipid-requiring phenotype revealed the absence of a fatty acid synthase gene and the presence of a β-oxidation pathway along with a large repertoire of auxillary genes for the degradation of exogenous fatty acids. A urease locus with the gene order
ureABCEFGD may play a pivotal role in virulence of
C. urealyticum by the alkalinization of human urine and the formation of struvite stones. Multidrug resistance of
C. urealyticum DSM7109 is mediated by transposable elements, conferring resistances to macrolides, lincosamides, ketolides, aminoglycosides, chloramphenicol, and tetracycline. The complete genome sequence of
C. urealyticum revealed a detailed picture of the lifestyle of this opportunistic human pathogen.</description><subject>Antibiotic resistance</subject><subject>Bacterial Proteins - genetics</subject><subject>Base Sequence</subject><subject>Chromosome Mapping - methods</subject><subject>Corynebacterium - genetics</subject><subject>Corynebacterium jeikeium</subject><subject>Corynebacterium urealyticum</subject><subject>Genome sequence</subject><subject>Genome, Bacterial - genetics</subject><subject>Molecular Sequence Data</subject><subject>Open Reading Frames - genetics</subject><subject>Sequence Analysis, DNA - methods</subject><subject>Urinary tract infection</subject><subject>Virulence factors</subject><subject>β-Oxidation</subject><issn>0168-1656</issn><issn>1873-4863</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhkVJaTZpf0JTnXqzoy97pVMJS5sWAjk0OQtZGm-02NZGkgP-99Wyhh5zmmH0zIzmfRH6SklNCW1vD_Wh8yGDrRkhsiasJkR9QBsqt7wSsuUXaFM4WdG2aS_RVUoHQohQDf2ELqnk7ZZJukH56QXw4HtIeRkAhx7vQlwm6IzNEP084jmCGZbsbcldKb2Bw30MI_Y5YRvG4wAZ8B6mMAJO8DrDZAGXeaYbfHopdLfg4xLD-uan_Wf0sTdDgi9rvEbPv34-7X5XD4_3f3Z3D5UVUuRKSeEU54w1UggJ28ZAXzJwjgPjTgEQ0dLeSdZyq8Ba2ijnjKJSEmEI5dfo-3nuMYayO2U9-mRhGMwEYU66VUJyxdm7IFVbxYgiBWzOoC33pAi9PkY_mrhoSvTJF33Qqy_65IsmTBdfSt_NumDuRnD_u1YjCvDtDPQmaLOPPunnv6zcQGjDixq8ED_OBBTF3jxEnaw_ae18BJu1C_6dT_wDajytCQ</recordid><startdate>20080831</startdate><enddate>20080831</enddate><creator>Tauch, Andreas</creator><creator>Trost, Eva</creator><creator>Tilker, Alexandra</creator><creator>Ludewig, Ulrike</creator><creator>Schneiker, Susanne</creator><creator>Goesmann, Alexander</creator><creator>Arnold, Walter</creator><creator>Bekel, Thomas</creator><creator>Brinkrolf, Karina</creator><creator>Brune, Iris</creator><creator>Götker, Susanne</creator><creator>Kalinowski, Jörn</creator><creator>Kamp, Paul-Bertram</creator><creator>Lobo, Francisco Pereira</creator><creator>Viehoever, Prisca</creator><creator>Weisshaar, Bernd</creator><creator>Soriano, Francisco</creator><creator>Dröge, Marcus</creator><creator>Pühler, Alfred</creator><general>Elsevier B.V</general><general>[New York, NY]: Elsevier</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20080831</creationdate><title>The lifestyle of Corynebacterium urealyticum derived from its complete genome sequence established by pyrosequencing</title><author>Tauch, Andreas ; 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We report the analysis of the complete genome sequence of
C. urealyticum DSM7109, which was initially recovered from a patient with alkaline-encrusted cystitis. The genome sequence was determined by a combination of pyrosequencing and Sanger technology. The chromosome of
C. urealyticum DSM7109 has a size of 2,369,219
bp and contains 2024 predicted coding sequences, of which 78% were considered as orthologous with genes in the
Corynebacterium jeikeium K411 genome. Metabolic analysis of the lipid-requiring phenotype revealed the absence of a fatty acid synthase gene and the presence of a β-oxidation pathway along with a large repertoire of auxillary genes for the degradation of exogenous fatty acids. A urease locus with the gene order
ureABCEFGD may play a pivotal role in virulence of
C. urealyticum by the alkalinization of human urine and the formation of struvite stones. Multidrug resistance of
C. urealyticum DSM7109 is mediated by transposable elements, conferring resistances to macrolides, lincosamides, ketolides, aminoglycosides, chloramphenicol, and tetracycline. The complete genome sequence of
C. urealyticum revealed a detailed picture of the lifestyle of this opportunistic human pathogen.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>18367281</pmid><doi>10.1016/j.jbiotec.2008.02.009</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of biotechnology, 2008-08, Vol.136 (1), p.11-21 |
| issn | 0168-1656 1873-4863 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Antibiotic resistance Bacterial Proteins - genetics Base Sequence Chromosome Mapping - methods Corynebacterium - genetics Corynebacterium jeikeium Corynebacterium urealyticum Genome sequence Genome, Bacterial - genetics Molecular Sequence Data Open Reading Frames - genetics Sequence Analysis, DNA - methods Urinary tract infection Virulence factors β-Oxidation |
| title | The lifestyle of Corynebacterium urealyticum derived from its complete genome sequence established by pyrosequencing |
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